Infection load as a predisposing factor for somatoform disorders: evidence from a Dutch General Practice Registry.

Abstract:

OBJECTIVE:Somatoform disorders (SDs) are characterized by chronic multiple functional somatic (FS) symptoms. It has been suggested that infections may be triggers for FS symptoms to occur, pointing to the immune system as a pathogenic factor in their development. The current study aimed to compare the prevalence of infections (i.e., infection load) in the history of patients with SDs with that of matched controls. METHODS:Samples (n = 185) were identified in the Psychiatric Case Register Middle Netherlands and the Julius General Practitioners Network. Patients with an SD diagnosis in the Psychiatric Case Register Middle Netherlands were compared with matched persons without somatoform complaints (controls) on their infection load in two periods before the date of the psychiatric diagnosis or a matched date for the controls (i.e., the total period for which data were available and a 3-year period). Infection load was defined as the total number of infections documented in the Julius General Practitioners Network. RESULTS:Patients with SD had significantly more infections than did controls in both periods (total period: mean [standard error] = 0.87 [0.10] versus 0.51 [0.06], z = -3.08, p = .002; 3-year period: 3.44 [0.47] versus 2.15 [0.50], z = -2.91, p = .004). CONCLUSIONS:Results show that patients with SD have a higher infection load preceding their diagnosis as compared with matched controls, implicating that infection load may indeed predispose for developing FS symptoms. These findings emphasize the importance of further research on immunological mechanisms in FS symptoms. Limitations of the study are discussed.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Lacourt TE,Houtveen JH,Smeets HM,Lipovsky MM,van Doornen LJ

doi

10.1097/PSY.0b013e3182a3d91f

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

759-64

issue

8

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3182a3d91f

journal_volume

75

pub_type

杂志文章
  • A comparison of cook-medley hostility subscales and mortality in patients with coronary heart disease: data from the heart and soul study.

    abstract:OBJECTIVE:Hostility is associated with adverse outcomes in patients with coronary heart disease (CHD). However, assessment tools used to evaluate hostility in epidemiological studies vary widely. METHODS:We administered nine subscales of the Cook-Medley Hostility Scale (CMHS) to 656 outpatients with stable CHD between...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000059

    authors: Wong JM,Sin NL,Whooley MA

    更新日期:2014-05-01 00:00:00

  • Waist-to-hip ratio is positively associated with bioavailable testosterone but negatively associated with sexual desire in healthy premenopausal women.

    abstract:OBJECTIVE:We examined whether high waist-to-hip ratio (WHR) in women is a biomarker for increased testosterone (T) and higher levels of sexual desire. METHODS:Participants were 99 healthy nonobese premenopausal women. Trait levels of mean bioavailable T were estimated from three saliva samples collected at 8:00 am, 9:...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000151747.22904.d7

    authors: van Anders SM,Hampson E

    更新日期:2005-03-01 00:00:00

  • Depression as an independent risk factor for mortality in critically ill patients.

    abstract:OBJECTIVE:Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a poss...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000137

    authors: Wewalka M,Warszawska J,Strunz V,Kitzberger R,Holzinger U,Fuhrmann V,Zauner C,Miehsler W,Moser G

    更新日期:2015-02-01 00:00:00

  • Association between self-reported dental health status and onset of dementia: a 4-year prospective cohort study of older Japanese adults from the Aichi Gerontological Evaluation Study (AGES) Project.

    abstract:OBJECTIVES:Studies have shown that people with cognitive impairment have poor dental health. However, the direction of causality remains unknown. This prospective cohort study aimed to determine the association between four self-reported dental health variables and dementia onset in older Japanese people. METHODS:Anal...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e318246dffb

    authors: Yamamoto T,Kondo K,Hirai H,Nakade M,Aida J,Hirata Y

    更新日期:2012-04-01 00:00:00

  • Electrophysiologic characteristics of respiratory suspension periods occurring during the practice of the Transcendental Meditation Program.

    abstract::In a study designed to identify the electrophysiologic characteristics of the Transcendental Meditation Program, 52 periods of spontaneous respiratory suspension (RS) were observed in 18 subjects during the practice of this program. These periods were correlated with some but not all the subjective experiences of pure...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198405000-00008

    authors: Badawi K,Wallace RK,Orme-Johnson D,Rouzere AM

    更新日期:1984-05-01 00:00:00

  • It's more than sex: exploring the dyadic nature of sleep and implications for health.

    abstract::Sleep is a critical health behavior and one that is typically shared between husbands and wives or romantic partners. However, the science of sleep has traditionally conceptualized and evaluated sleep at the level of the individual. Considering the social context of sleep represents a significant shift in sleep resear...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/PSY.0b013e3181de7ff8

    authors: Troxel WM

    更新日期:2010-07-01 00:00:00

  • Monitoring for sleep-related threat: a pilot study of the Sleep Associated Monitoring Index (SAMI).

    abstract:OBJECTIVE:The aims of this pilot study were: 1) to establish the reliability and validity of a new self-report instrument designed to index monitoring for sleep-related threat; 2) to determine the presence of ten monitoring types proposed in a recent cognitive model of insomnia and to examine the relationship between m...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000114870.50968.90

    authors: Semler CN,Harvey AG

    更新日期:2004-03-01 00:00:00

  • A life-style physical activity intervention and the antibody response to pneumococcal vaccination in women.

    abstract:OBJECTIVE:To assess whether a life-style physical activity intervention improved antibody response to a pneumococcal vaccination in sedentary middle-aged women. METHODS:Eighty-nine sedentary women completed a 16-week exercise (physical activity consultation, pedometer, telephone/e-mail prompts; n = 44) or control (adv...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0b013e3182a0b664

    authors: Long JE,Ring C,Bosch JA,Eves F,Drayson MT,Calver R,Say V,Allen D,Burns VE

    更新日期:2013-10-01 00:00:00

  • Nighttime heart rate and survival in depressed patients post acute myocardial infarction.

    abstract:OBJECTIVES:To determine if: 1) depressed patients with a recent acute myocardial infarction (AMI) have higher nighttime heart rate (HR) than nondepressed patients, and 2) elevated nighttime HR is associated with decreased survival post AMI. Depression is a risk factor for mortality post AMI. It is also associated with ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181835ca3

    authors: Carney RM,Steinmeyer B,Freedland KE,Blumenthal JA,Stein PK,Steinhoff WA,Howells WB,Berkman LF,Watkins LL,Czajkowski SM,Domitrovich PP,Burg MM,Hayano J,Jaffe AS

    更新日期:2008-09-01 00:00:00

  • Depression predicts revascularization procedures for 5 years after coronary angiography.

    abstract:OBJECTIVE:Depression has been reported to increase cardiac event rates and functional impairment in patients with coronary disease. This article describes the impact of depression on subsequent healthcare utilization for such patients. METHODS:One hundred ninety-eight health maintenance organization patients with stab...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000058370.50240.aa

    authors: Sullivan MD,LaCroix AZ,Spertus JA,Hecht J,Russo J

    更新日期:2003-03-01 00:00:00

  • Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women-The Women's Health Initiative.

    abstract:OBJECTIVE:Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). METHODS:We conducted a longitudinal analysis using data f...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000672

    authors: Salmoirago-Blotcher E,Hovey KM,Andrews CA,Allison M,Brunner RL,Denburg NL,Eaton C,Garcia L,Sealy-Jefferson SM,Zaslavsky O,Kang J,López L,Post SG,Tindle H,Wassertheil-Smoller S

    更新日期:2019-04-01 00:00:00

  • Genetic influence on blood pressure and underlying hemodynamics measured at rest and during stress.

    abstract:OBJECTIVE:This study examined the genetic and environmental contributions to the individual differences in blood pressure (BP) levels and underlying hemodynamic characteristics at rest and during mental challenge tasks in a large twin cohort of youth. Including both European American and African American twins further ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31828d3cb6

    authors: Wu T,Treiber FA,Snieder H

    更新日期:2013-05-01 00:00:00

  • Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).

    abstract:OBJECTIVE:Melissa officinalis (lemon balm) is contemporaneously used as a mild sedative and/or calming agent. Although recent research has demonstrated modulation of mood in keeping with these roles, no studies to date have directly investigated the effects of this herbal medication on laboratory-induced psychological ...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.psy.0000132877.72833.71

    authors: Kennedy DO,Little W,Scholey AB

    更新日期:2004-07-01 00:00:00

  • Social competence interview for assessing physiological reactivity in adolescents.

    abstract::Difficulties in predicting "real life" physiological variation from responses to controlled stress tasks suggest the need for more ecologically valid laboratory challenges. The Social Competence Interview (SCI) measures physiological changes elicited by re-experiencing a life situation in which a valued striving was u...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199105000-00003

    authors: Ewart CK,Kolodner KB

    更新日期:1991-05-01 00:00:00

  • Epidemiology of anorexia nervosa in Monroe County, New York: 1960-1976.

    abstract::The Monroe County Psychiatric Case Register and hospital records were used to investigate the incidence of anorexia nervosa in Monroe County, New York, during the periods 1960-1969 and 1979-1976 to determine whether the number of newly diagnosed cases has increased over time. The results support the general clinical i...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198011000-00003

    authors: Jones DJ,Fox MM,Babigian HM,Hutton HE

    更新日期:1980-11-01 00:00:00

  • Screening for DSM-5 Somatic Symptom Disorder: Diagnostic Accuracy of Self-Report Measures Within a Population Sample.

    abstract:OBJECTIVE:The new DSM-5 somatic symptom disorder was introduced to improve the diagnosis of persons experiencing what used to be called somatoform disorders. So far, it is unclear whether existing self-report measures are useful to detect the new somatic symptom disorder. This study investigates the diagnostic accuracy...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000530

    authors: Laferton JAC,Stenzel NM,Rief W,Klaus K,Brähler E,Mewes R

    更新日期:2017-11-01 00:00:00

  • Decreased bone mineral density in medicated psychiatric patients.

    abstract::Osteoporosis is a common problem in postmenopausal women. It has been linked to estrogen deficiency, other neuroendocrine processes such as hypercortisolemia and male hypogonadism, nutritional deficiencies, and other mechanisms. Some of these changes have been also reported in male and female patients with mental diso...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199509000-00011

    authors: Halbreich U,Rojansky N,Palter S,Hreshchyshyn M,Kreeger J,Bakhai Y,Rosan R

    更新日期:1995-09-01 00:00:00

  • Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation.

    abstract:OBJECTIVE:Numerous theories have proposed that acute and chronic stressors may exert a cumulative effect on life-span health by causing biological "wear and tear," or allostatic load, which in turn promotes disease. Very few studies have directly tested such models, though, partly because of the challenges associated w...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000534

    authors: Slavich GM,Shields GS

    更新日期:2018-01-01 00:00:00

  • The relation between dominance, anger, and hormones in normally aging men: results from the Massachusetts Male Aging Study.

    abstract::This paper examines the relation of two personality characteristics (dominance and anger) to hormones in normally aging men. The relation of the Jackson Personality Research Form E Dominance subscale and the Spielberger Anger Expression scale to serum levels of 17 endocrine variables, including testosterone (T) and di...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199107000-00003

    authors: Gray A,Jackson DN,McKinlay JB

    更新日期:1991-07-01 00:00:00

  • The relationship of interleukin-1 and immune functions to sleep in humans.

    abstract::Serial sampling of peripheral blood from six healthy adult male volunteers was performed during daytime waking and nighttime sleeping. In addition, sleep physiology was assessed in all subjects (Ss) and sleep stages scored blind by standard criteria. Samples of plasma were analyzed for cortisol (Co) levels, functional...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198605000-00001

    authors: Moldofsky H,Lue FA,Eisen J,Keystone E,Gorczynski RM

    更新日期:1986-05-01 00:00:00

  • Behavioral and physiological effects of a beta blocker and relaxation therapy on mild hypertensives.

    abstract::In this industrial-based study we compared the blood pressure (BP)-lowering effectiveness of relaxation, a beta blocker, and the combined use of these two treatments in 47 untreated, mildly hypertensive blue collar steel workers. Using a randomized two by two factorial design, patients received either nadolol or place...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006842-198909000-00004

    authors: Adsett CA,Bellissimo A,Mitchell A,Wilczynski N,Haynes RB

    更新日期:1989-09-01 00:00:00

  • Caffeine raises blood pressure at work.

    abstract:OBJECTIVE:The study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate during workday activities. METHODS:Healthy, nonsmoking, habitual coffee drinkers (N = 21) received daily doses of 100 mg and 500 mg of caffeine on 2 days in a crossover design. Treatment order was ran...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006842-199805000-00019

    authors: Lane JD,Phillips-Bute BG,Pieper CF

    更新日期:1998-05-01 00:00:00

  • Cardiovascular-emotional dampening: the relationship between blood pressure and recognition of emotion.

    abstract:OBJECTIVE:Persons with elevated blood pressure (BP) show dampened emotional responses to affect-laden stimuli. We sought to further examine cardiovascular-emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African American community-based sample....

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e318235ed55

    authors: McCubbin JA,Merritt MM,Sollers JJ 3rd,Evans MK,Zonderman AB,Lane RD,Thayer JF

    更新日期:2011-11-01 00:00:00

  • Association between depression and inflammation--differences by race and sex: the META-Health study.

    abstract:OBJECTIVE:To test whether the association between depression and inflammation differs by race and sex. Depressive symptoms have been associated with higher levels of C-reactive protein (CRP). However, few studies have examined this association in samples including a significant number of African Americans, or examined ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e318222379c

    authors: Morris AA,Zhao L,Ahmed Y,Stoyanova N,De Staercke C,Hooper WC,Gibbons G,Din-Dzietham R,Quyyumi A,Vaccarino V

    更新日期:2011-07-01 00:00:00

  • The impatience of youth: phasic cardiovascular response in type A and type B elementary school-aged boys.

    abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198411000-00003

    authors: Jennings JR,Matthews KA

    更新日期:1984-11-01 00:00:00

  • Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression.

    abstract:OBJECTIVE:To examine retinal vascular caliber, an indicator of early microvascular disease and depression in patients with Type 2 diabetes. METHODS:We conducted a clinic-based study, comparing participants with Type 2 diabetes with major depression (n = 43), without depression (n = 49), and healthy controls without di...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181da90f4

    authors: Nguyen TT,Wong TY,Islam FM,Hubbard L,Ajilore O,Haroon E,Darwin C,Esser B,Kumar A

    更新日期:2010-07-01 00:00:00

  • Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability.

    abstract:OBJECTIVE:To examine whether high-frequency heart rate variability, an indirect measure of parasympathetic (vagal) control over variations in heart rate, is associated with immune reactivity to an in vitro inflammatory challenge. Convergent evidence from the animal literature shows that the autonomic nervous system pla...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181576118

    authors: Marsland AL,Gianaros PJ,Prather AA,Jennings JR,Neumann SA,Manuck SB

    更新日期:2007-11-01 00:00:00

  • Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

    abstract:OBJECTIVES:Subtle alterations of the hypothalamic-pituitary-adrenal (HPA) axis in chronic fatigue syndrome (CFS) have been proposed as a shared pathway linking numerous etiological and perpetuating processes with symptoms and observed physiological abnormalities. Because the HPA axis is involved in the adaptive respons...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000038937.67401.61

    authors: Gaab J,Hüster D,Peisen R,Engert V,Heitz V,Schad T,Schürmeyer TH,Ehlert U

    更新日期:2002-11-01 00:00:00

  • Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women.

    abstract:OBJECTIVE:Brain-gut-microbiota interactions may play an important role in human health and behavior. Although rodent models have demonstrated effects of the gut microbiota on emotional, nociceptive, and social behaviors, there is little translational human evidence to date. In this study, we identify brain and behavior...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000493

    authors: Tillisch K,Mayer EA,Gupta A,Gill Z,Brazeilles R,Le Nevé B,van Hylckama Vlieg JET,Guyonnet D,Derrien M,Labus JS

    更新日期:2017-10-01 00:00:00

  • Psychomotor coordination and intelligence in childhood and health in adulthood--testing the system integrity hypothesis.

    abstract:OBJECTIVES:To examine associations between intelligence and psychomotor coordination in childhood and risk of psychological distress, poorer self-rated health, and obesity in adulthood. To investigate whether psychomotor coordination as a potential marker of the construct "system integrity" explains associations betwee...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181a63b2e

    authors: Gale CR,Batty GD,Cooper C,Deary IJ

    更新日期:2009-07-01 00:00:00