Depressive symptoms predict norepinephrine response to a psychological stressor task in Alzheimer's caregivers.

Abstract:

OBJECTIVE:Increased depressive symptoms have been associated with increased basal plasma norepinephrine (NE), and may be associated with exaggerated NE response to stress. This exaggerated response may play a role in health consequences associated with caring for a loved-one with Alzheimer's disease. The current study examined the relations between the level of depressive symptoms in spousal caregivers and the physiological response to a psychological stress task. METHODS:Fifty-five spousal caregivers (mean age 73 +/- 8 years) completed the depression subscale of the Brief Symptom Inventory (BSI). Plasma NE levels were assessed before and immediately after a speech stressor conducted at the caregiver's home. Hierarchical linear regression was used to determine whether caregiver depressive symptoms significantly improved prediction of change in NE levels beyond other factors theoretically and empirically related to NE. RESULTS:Level of depressive symptoms significantly predicted post-stressor change in NE levels (p < .01), even when controlling for age, caregiver distress, presence of caregiver hypertension, and care recipient level of cognitive function. Higher levels of depressive symptoms were associated with a greater plasma NE response to the psychological stress task. CONCLUSIONS:Depressive symptoms may act to exaggerate NE response to the stress of caregiving, potentially leading to an allostatic load that might predispose caregivers to negative health consequences, including cardiovascular morbidity.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Mausbach BT,Dimsdale JE,Ziegler MG,Mills PJ,Ancoli-Israel S,Patterson TL,Grant I

doi

10.1097/01.psy.0000173312.90148.97

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

638-42

issue

4

eissn

0033-3174

issn

1534-7796

pii

67/4/638

journal_volume

67

pub_type

杂志文章
  • Relationship between work stress and body mass index among 45,810 female and male employees.

    abstract:OBJECTIVE:The proportion of overweight and obese people has grown rapidly, and obesity has now been widely recognized as an important public health problem. At the same time, stress has increased in working life. The 2 problems could be connected if work stress promotes unhealthy eating habits and sedentary behavior an...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000170330.08704.62

    authors: Kouvonen A,Kivimäki M,Cox SJ,Cox T,Vahtera J

    更新日期:2005-07-01 00:00:00

  • Sleep deprivation affects thermal pain thresholds but not somatosensory thresholds in healthy volunteers.

    abstract:OBJECTIVE:Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects. It is still unclear whether these changes are truly specific to pain and not related to general changes in somatosensory functions. The aim of the present study was to evaluate the effect o...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.psy.0000145912.24553.c0

    authors: Kundermann B,Spernal J,Huber MT,Krieg JC,Lautenbacher S

    更新日期:2004-11-01 00:00:00

  • It's more than sex: exploring the dyadic nature of sleep and implications for health.

    abstract::Sleep is a critical health behavior and one that is typically shared between husbands and wives or romantic partners. However, the science of sleep has traditionally conceptualized and evaluated sleep at the level of the individual. Considering the social context of sleep represents a significant shift in sleep resear...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/PSY.0b013e3181de7ff8

    authors: Troxel WM

    更新日期:2010-07-01 00:00:00

  • Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression.

    abstract:OBJECTIVE:To examine retinal vascular caliber, an indicator of early microvascular disease and depression in patients with Type 2 diabetes. METHODS:We conducted a clinic-based study, comparing participants with Type 2 diabetes with major depression (n = 43), without depression (n = 49), and healthy controls without di...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181da90f4

    authors: Nguyen TT,Wong TY,Islam FM,Hubbard L,Ajilore O,Haroon E,Darwin C,Esser B,Kumar A

    更新日期:2010-07-01 00:00:00

  • Depressed mood, positive affect, and heart rate variability in patients with suspected coronary artery disease.

    abstract:OBJECTIVE:To test associations between heart rate variability (HRV), depressed mood, and positive affect in patients with suspected coronary artery disease (CAD). Depression is associated with impaired HRV post acute cardiac events, but evidence in patients with stable coronary artery disease (CAD) is inconsistent. ME...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/PSY.0b013e318189afcc

    authors: Bhattacharyya MR,Whitehead DL,Rakhit R,Steptoe A

    更新日期:2008-11-01 00:00:00

  • Sleep disorder and psychobiological symptomatology in male psychiatric outpatients and male nonpatients.

    abstract::Sleep disturbance was studied in relation to psychiatric and physical symptoms for 214 male psychiatric outpatients and 248 male nonpatients. Our self-report instrument required that subjects describe the frequency of symptoms precisely on a five-point scale from "every day" to "not at all." Percentages are based on t...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-197611000-00002

    authors: Sweetwood HL,Kripke DF,Grant I,Yager J,Gerst MS

    更新日期:1976-11-01 00:00:00

  • Social integration and mortality in patients with coronary heart disease: findings from the Heart and Soul Study.

    abstract:OBJECTIVE:To determine why lower social integration predicts higher mortality in patients with coronary heart disease (CHD). METHODS:The association between social integration and mortality was examined prospectively in 1019 outpatients with stable CHD from the Heart and Soul Study. Baseline social integration was ass...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000100

    authors: Kreibig SD,Whooley MA,Gross JJ

    更新日期:2014-10-01 00:00:00

  • Going forth to meet the environment: a developmental study of seven infants with esophageal atresia.

    abstract::The development of seven esophageal atresia infants is described. These children differed in the quality of maternal care received and the amount of oral experience permitted during the first year of life. Observation of these infants suggest differences between effects of maternal depression and effects of abnormal o...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198001001-00010

    authors: Dowling S

    更新日期:1980-01-01 00:00:00

  • Suppressed anger and blood pressure: the effects of race, sex, social class, obesity, and age.

    abstract::We studied 572 men and women who participated in a blood pressure screening program at a government unemployment office. Before having their blood pressures taken, the subjects completed a brief questionnaire that included two items measuring conflict over anger expression. Information was also obtained on obesity, ra...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198607000-00005

    authors: Dimsdale JE,Pierce C,Schoenfeld D,Brown A,Zusman R,Graham R

    更新日期:1986-07-01 00:00:00

  • Hyperventilation in anticipatory music performance anxiety.

    abstract:OBJECTIVES AND METHODS:Self-report studies have shown an association between music performance anxiety (MPA) and hyperventilation complaints. However, hyperventilation was never assessed physiologically in MPA. This study investigated the self-reported affective experience, self-reported physiological symptoms, and car...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31825e3578

    authors: Studer RK,Danuser B,Hildebrandt H,Arial M,Wild P,Gomez P

    更新日期:2012-09-01 00:00:00

  • Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging.

    abstract:OBJECTIVE:To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions. METHODS:We used a prospective twin study with a 12-year follow-up. In 1992, lifetime diagnosis of depression was assessed in 1159 male-male twins and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0b013e3181d28125

    authors: Xian H,Scherrer JF,Franz CE,McCaffery J,Stein PK,Lyons MJ,Jacobsen K,Eisen SA,Kremen WS

    更新日期:2010-05-01 00:00:00

  • Modeling social influences on human health.

    abstract::Social interactions have long-term physiological, psychological, and behavioral consequences. Social isolation is a well-recognized but little understood risk factor and prognostic marker of disease; it can have profoundly detrimental effects on both mental and physical well-being, particularly during states of compro...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/PSY.0b013e3182002116

    authors: Karelina K,DeVries AC

    更新日期:2011-01-01 00:00:00

  • Childhood Cognitive Ability and Age-Related Changes in Physical Capability From Midlife: Findings From a British Birth Cohort Study.

    abstract:OBJECTIVE:The aim of the study was to test the hypothesis that higher childhood cognitive ability is associated with reduced risk of decline in physical capability in late midlife. METHODS:Participants were 1954 men and women from the Medical Research Council National Survey of Health and Development with complete dat...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000482

    authors: Cooper R,Richards M,Kuh D

    更新日期:2017-09-01 00:00:00

  • The Role of Disadvantaged Neighborhood Environments in the Association of John Henryism With Hypertension and Obesity.

    abstract:OBJECTIVE:The John Henryism hypothesis proposes that high-effort, active coping in impoverished, low-resource environments is associated with an increased risk of cardiovascular disease, but a lower risk of disease in a high-resource environment. To test this hypothesis, we examined the association of John Henryism Act...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000308

    authors: Booth JM,Jonassaint CR

    更新日期:2016-06-01 00:00:00

  • Negative affectivity and repressive coping: pervasive influence on self-reported mood, health, and coronary-prone behavior.

    abstract::Negative affectivity (NA) and repressive coping (REP) are coping styles characterized by a disposition to either experience or avoid distress. This study investigated the potential influence of NA and REP on self-reported distress and coronary-prone behavior among 178 male cardiac patients undergoing rehabilitation. B...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199109000-00005

    authors: Denollet J

    更新日期:1991-09-01 00:00:00

  • Long-term effects of a complex behavioral treatment of essential hypertension.

    abstract::A multidimensional behavioral program was developed for the treatment of essential hypertension. Over a course of 6 weeks, 108 patients of a rehabilitation center were treated with this program consisting of health education, self-monitoring of blood pressure, relaxation techniques, and a social skill training in addi...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198707000-00011

    authors: Lehnert H,Kaluza K,Vetter H,Losse H,Dorst K

    更新日期:1987-07-01 00:00:00

  • Low Control and High Demands at Work as Risk Factors for Suicide: An Australian National Population-Level Case-Control Study.

    abstract:OBJECTIVE:Previous research suggests that psychosocial job stressors may be plausible risk factors for suicide. This study assessed the relationship between psychosocial job stressors and suicide mortality across the Australian population. METHODS:We developed a job exposure matrix to objectively measure job stressors...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000389

    authors: Milner A,Spittal MJ,Pirkis J,Chastang JF,Niedhammer I,LaMontagne AD

    更新日期:2017-04-01 00:00:00

  • Modeling and reinforcement of the sick role during childhood predicts adult illness behavior.

    abstract::Previous studies suggest that the ways in which parents respond to children's health complaints (reinforcement) and the ways in which they cope with their own illnesses (modeling) influence the frequency of symptoms, disability days, and health care visits made by these children when they grow up. However, previous st...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199411000-00010

    authors: Whitehead WE,Crowell MD,Heller BR,Robinson JC,Schuster MM,Horn S

    更新日期:1994-11-01 00:00:00

  • Brain Functional Connectivity in Patients With Somatic Symptom Disorder.

    abstract:OBJECTIVE:The aim of the study was to evaluate whether individuals with somatic symptom disorder (SSD) display increased resting-state functional connectivity (FC) within and between the sensorimotor network (SMN), default mode network (DMN), salience network, and dorsal attention network (DAN). METHODS:Eighteen patie...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000681

    authors: Kim SM,Hong JS,Min KJ,Han DH

    更新日期:2019-04-01 00:00:00

  • Cultural variations in response to painful stimuli.

    abstract::This review updates the literature on cultural differences in response to laboratory-induced pain. Thirteen studies were located, and there was great diversity among the investigations with regard to racial and ethnic groups studied, methods of pain induction, and experimental outcome. There appear to be no racial/eth...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00006842-199009000-00007

    authors: Zatzick DF,Dimsdale JE

    更新日期:1990-09-01 00:00:00

  • Social problem solving and noncardiac chest pain.

    abstract:OBJECTIVE:To investigate differences in social problem solving (SPS) between individuals with noncardiac chest pain (NCCP) and persons with chest pain who tested positive for underlying cardiac disease. METHODS:The major design involved a matched case-control methodology and compared a group of patients with NCCP (n =...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31815a995a

    authors: Nezu AM,Nezu CM,Jain D,Xanthopoulos MS,Cos TA,Friedman J,Lee M

    更新日期:2007-12-01 00:00:00

  • Neural Correlates of Stress and Abdominal Obesity in Patients With Coronary Artery Disease.

    abstract:OBJECTIVE:This study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD). METHODS:Patients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000776

    authors: Moazzami K,Wittbrodt MT,Lima BB,Levantsevych O,Kaseer B,Martini A,Haffar A,Nye JA,Quyyumi AA,Shah A,Vaccarino V,Bremner JD

    更新日期:2020-04-01 00:00:00

  • Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations.

    abstract:OBJECTIVE:Elevated body mass index (BMI) at midlife is associated with increased risk of cognitive decline in later life. The goal of the current study was to assess mechanisms of early brain vulnerability by examining if higher BMI at midlife affects current cognitive performance through alterations in cerebral neuroc...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31825ff1de

    authors: Gonzales MM,Tarumi T,Eagan DE,Tanaka H,Vaghasia M,Haley AP

    更新日期:2012-09-01 00:00:00

  • Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women-The Women's Health Initiative.

    abstract:OBJECTIVE:Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). METHODS:We conducted a longitudinal analysis using data f...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000672

    authors: Salmoirago-Blotcher E,Hovey KM,Andrews CA,Allison M,Brunner RL,Denburg NL,Eaton C,Garcia L,Sealy-Jefferson SM,Zaslavsky O,Kang J,López L,Post SG,Tindle H,Wassertheil-Smoller S

    更新日期:2019-04-01 00:00:00

  • Women with eating disorder tendencies display altered cardiovascular, neuroendocrine, and psychosocial profiles.

    abstract:OBJECTIVE:Cardiovascular, neuroendocrine, and psychosocial profiles were investigated in women with eating disorder tendencies, but who had never met clinical criteria for an eating disorder, and in healthy controls. METHODS:Twenty-six women who scored in the highest distribution of the Eating Disorder Inventory bulim...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200007000-00013

    authors: Koo-Loeb JH,Costello N,Light KC,Girdler SS

    更新日期:2000-07-01 00:00:00

  • Association of baseline anxiety with depression persistence at 6 months in patients with acute cardiac illness.

    abstract:OBJECTIVE:To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization. METHODS:Data were analyzed from 137 depressed patients hospitalized on inpatient cardiac units for acute coronary syndrome, decompensated heart failure, or arrhy...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0b013e31823d38bc

    authors: Celano CM,Mastromauro CA,Lenihan EC,Januzzi JL,Rollman BL,Huffman JC

    更新日期:2012-01-01 00:00:00

  • Another Step Toward Clarifying the Benefits and Burdens of Selective Serotonin Reuptake Inhibitors.

    abstract::Selective serotonin reuptake inhibitors (SSRIs) have substantial beneficial effects for the treatment of major depressive mood disorders and other conditions but can also result in unwanted clinical outcomes. One of the reported disadvantages of SSRIs, based on cross-sectional studies, is their adverse effects on glyc...

    journal_title:Psychosomatic medicine

    pub_type: 评论,社论

    doi:10.1097/PSY.0000000000000735

    authors: Wulsin LR

    更新日期:2019-09-01 00:00:00

  • Association between depression and inflammation--differences by race and sex: the META-Health study.

    abstract:OBJECTIVE:To test whether the association between depression and inflammation differs by race and sex. Depressive symptoms have been associated with higher levels of C-reactive protein (CRP). However, few studies have examined this association in samples including a significant number of African Americans, or examined ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e318222379c

    authors: Morris AA,Zhao L,Ahmed Y,Stoyanova N,De Staercke C,Hooper WC,Gibbons G,Din-Dzietham R,Quyyumi A,Vaccarino V

    更新日期:2011-07-01 00:00:00

  • Presidential Address-1976. Social support as a moderator of life stress.

    abstract::Social support is defined as information leading the subject to believe that he is cared for and loved, esteemed, and a member of a network of mutual obligations. The evidence that supportive interactions among people are protective against the health consequences of life stress is reviewed. It appears that social sup...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-197609000-00003

    authors: Cobb S

    更新日期:1976-09-01 00:00:00

  • Blood pressure increases while signing in a deaf population.

    abstract::Recent technologic advances have permitted the observation of rapid and significant increases in blood pressure (BP) during verbal communication. The magnitude of the increase in BP is influenced by rate of speech, audience size, status, affective content, environmental setting, and resting BP. The current study evalu...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198601000-00008

    authors: Malinow KL,Lynch JJ,Foreman PJ,Friedmann E,Thomas SA

    更新日期:1986-01-01 00:00:00