Neural Correlates of Stress and Abdominal Obesity in Patients With Coronary Artery Disease.

Abstract:

OBJECTIVE:This study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD). METHODS:Patients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron emission tomography and radiolabeled water imaging of the brain. Brain responses to mental stress were correlated with waist circumference. RESULTS:Waist circumference was positively correlated with increased activation in the right and left frontal lobes (β values ranging from 2.81 to 3.75 in the paracentral, medial, and superior gyri), left temporal lobe, left hippocampal, left amygdala, left uncus, and left anterior and posterior cingulate gyri (β values ranging from 2.93 to 3.55). Waist circumference was also negatively associated with the left and right parietal lobes, right superior temporal gyrus, and right insula and precuneus (β values ranging from 2.82 to 5.20). CONCLUSION:Increased brain activation in the brain regions involved in the stress response and autonomic regulation of the cardiovascular system during psychological stress may underlie stress-induced overeating and abdominal obesity in patients with CAD.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Moazzami K,Wittbrodt MT,Lima BB,Levantsevych O,Kaseer B,Martini A,Haffar A,Nye JA,Quyyumi AA,Shah A,Vaccarino V,Bremner JD

doi

10.1097/PSY.0000000000000776

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

272-280

issue

3

eissn

0033-3174

issn

1534-7796

journal_volume

82

pub_type

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