Effects of sleep on endotoxin-induced host responses in healthy men.

Abstract:

OBJECTIVE:To examine whether increased sleep during viral or bacterial infections supports host defense mechanisms. METHODS:To test this assumption in humans, healthy male subjects were assigned either to sleep from 2300 to 0700 hours (n = 10) or to stay awake through the night (n = 10). In the sleeping subjects Salmonella abortus equi endotoxin (0.4 ng/kg) or placebo were intravenously injected in balanced order during the first SWS episode. The age-matched, sleep-deprived subjects were injected at the same time point. RESULTS:As expected, endotoxin significantly increased rectal temperature, the plasma levels of cortisol, tumor necrosis factor-alpha (TNF-alpha), the soluble TNF receptors p55 and p75, Interleukin (IL)-6, the IL-1 receptor antagonist (RA), leukocyte, and granulocyte counts in both sleeping and sleep-deprived subjects, whereas lymphocyte and monocyte counts were transiently reduced. Time courses of endotoxin-induced host responses did not differ between the sleep and sleep deprivation groups. Endotoxin did not affect the amount of nocturnal wakefulness, nonrapid-eye-movement (NREM) sleep, or rapid-eye-movement (REM) sleep across the total night compared with placebo, but significantly increased electroencephalogram-arousals (EEG-arousals) in stage 2 and decreased arousals in SWS. In addition, the amount of SWS, spectral EEG-delta and -theta power was increased at the beginning and at the end of the sleep period, respectively, when the degree of immune activation was relatively low. CONCLUSION:The present results support the notion that short-term sleep deprivation is unlikely to harm the immune system as far as unspecific acute responses are concerned. The effects of endotoxin on sleep in this case support prior observations that in humans, enhanced SWS and intensified NREM sleep occur when host defense activation is subtle.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Haack M,Schuld A,Kraus T,Pollmächer T

doi

10.1097/00006842-200107000-00008

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

568-78

issue

4

eissn

0033-3174

issn

1534-7796

journal_volume

63

pub_type

临床试验,杂志文章,随机对照试验
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  • Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence: the Ryukyus Child Health Study.

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    更新日期:2010-10-01 00:00:00

  • Coronary Artery Spasm, Coronary Reactivity, and Their Psychological Context.

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    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1989-09-01 00:00:00

  • Childhood Bullying Victimization and Overweight in Young Adulthood: A Cohort Study.

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    更新日期:2016-11-01 00:00:00

  • It's more than sex: exploring the dyadic nature of sleep and implications for health.

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    更新日期:2007-06-01 00:00:00

  • Altered blood coagulation in patients with posttraumatic stress disorder.

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

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    更新日期:2006-07-01 00:00:00

  • Effects of coffee on cardiovascular responses to stress: a 14-week controlled trial.

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    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1992-05-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1994-11-01 00:00:00

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    pub_type: 杂志文章

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  • Trends in ambulatory self-report: the role of momentary experience in psychosomatic medicine.

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    pub_type: 杂志文章

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  • Genetic influence on blood pressure and underlying hemodynamics measured at rest and during stress.

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  • Childhood Adversity and Pain Sensitization.

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    pub_type: 杂志文章

    doi:10.1097/00006842-198701000-00004

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    更新日期:1987-01-01 00:00:00

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    authors: Van Egeren LF

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    pub_type: 杂志文章

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  • Hostility is associated with visceral, but not subcutaneous, fat in middle-aged African American and white women.

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