Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression.

Abstract:

OBJECTIVE:To examine retinal vascular caliber, an indicator of early microvascular disease and depression in patients with Type 2 diabetes. METHODS:We conducted a clinic-based study, comparing participants with Type 2 diabetes with major depression (n = 43), without depression (n = 49), and healthy controls without diabetes or depression (n = 54). Retinal vascular caliber was measured from digital photographs. Depression status was determined, using standardized clinical assessment. RESULTS:After adjusting for age and gender, participants with diabetes and depression had larger arteriolar and venular calibers (147.7 microm for arteriolar and 215.7 microm for venular calibers) than participants with diabetes but without depression (143.3 microm and 213.9 microm) and healthy controls (135.8 microm and 202.5 microm, p for trend = .002 for arteriolar and p = .02 for venular caliber). In multivariate models adjusting for duration of diabetes, systolic blood pressure, cigarette smoking, serum glucose, Cerebrovascular Risk Factor Scale, Cumulative Illness Rating Scale, and retinopathy levels, this relationship remained significant for retinal arterioles (p = .02) but not for retinal venules (p = .10). CONCLUSIONS:These data show that patients with Type 2 diabetes with major depression have wider retinal arterioles, supporting the concept that depression is associated with early microvascular changes in Type 2 diabetes.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Nguyen TT,Wong TY,Islam FM,Hubbard L,Ajilore O,Haroon E,Darwin C,Esser B,Kumar A

doi

10.1097/PSY.0b013e3181da90f4

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

535-8

issue

6

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3181da90f4

journal_volume

72

pub_type

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