Abstract:
OBJECTIVE:Elevated body mass index (BMI) at midlife is associated with increased risk of cognitive decline in later life. The goal of the current study was to assess mechanisms of early brain vulnerability by examining if higher BMI at midlife affects current cognitive performance through alterations in cerebral neurochemistry. METHODS:Fifty-five participants, aged 40 to 60 years, underwent neuropsychological testing, health screen, and proton magnetic resonance spectroscopy examining N-acetylaspartate, creatine (Cr), myo-inositol (mI), choline, and glutamate concentrations in occipitoparietal gray matter. Concentrations of N-acetylaspartate, choline, mI, and glutamate were calculated as a ratio over Cr and examined in relation to BMI using multivariate regression analyses. Structural equation modeling was used to determine if BMI had an indirect effect on cognition through cerebral metabolite levels. RESULTS:Higher BMI was associated with elevations in mI/Cr (F(5,45) = 3.843, p = .006, β = 0.444, p = .002), independent of age, sex, fasting glucose levels, and systolic blood pressure. Moreover, a χ(2) difference test of the direct and indirect structural equation models revealed that BMI had an indirect effect on global cognitive performance (Δχ(2) = 19.939, df = 2, p < .001). Subsequent follow-up analyses revealed that this effect was specific to memory (Δχ(2) = 22.027, df = 2, p < .001). CONCLUSIONS:Higher BMI was associated with elevations in mI/Cr concentrations in the occipitoparietal gray matter and indirectly related to poorer memory performance through mI/Cr levels, potentially implicating plasma hypertonicity and neuroinflammation as mechanisms underlying obesity-related brain vulnerability.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Gonzales MM,Tarumi T,Eagan DE,Tanaka H,Vaghasia M,Haley APdoi
10.1097/PSY.0b013e31825ff1desubject
Has Abstractpub_date
2012-09-01 00:00:00pages
691-8issue
7eissn
0033-3174issn
1534-7796pii
PSY.0b013e31825ff1dejournal_volume
74pub_type
杂志文章abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198411000-00003
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to examine the extent of clustering of smoking, high levels of television watching, overweight, and high blood pressure among adolescents and whether this clustering varies by socioeconomic position and cognitive function. METHODS:This study was a cross-sectional analysis o...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31825c85ca
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318268978e
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abstract:OBJECTIVE:To investigate efficacy and safety of St. John's wort (SJW) LI 160 in somatoform disorders. METHODS:In a prospective, randomized, placebo-controlled, and double-blind parallel group study, 184 outpatients with somatization disorder (ICD-10 F45.0), undifferentiated somatoform disorder (F45.1), and somatoform ...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000128900.13711.5b
更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/01.psy.0000170330.08704.62
更新日期:2005-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181f02f15
更新日期:2010-10-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197603000-00003
更新日期:1976-03-01 00:00:00
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更新日期:2013-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/PSY.0b013e318189afcc
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:This case report describes the use of sacral neuromodulation to treat urinary retention after sexual abuse. METHODS:Sacral neuromodulation was added to therapeutic regimen of a 38-year-old woman in whom chronic, complete urinary retention developed after psychological and sexual abuse during childhood. RESU...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200105000-00022
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:Accurate perception of asthma episodes increases the likelihood that they will be managed effectively. The purpose of the study was to examine the effect of feedback in a signal detection task on perception of increased airflow obstruction in children with persistent asthma. METHODS:The effect of feedback tr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e3182a8bcde
更新日期:2013-10-01 00:00:00
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doi:10.1097/PSY.0b013e3182826881
更新日期:2013-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00006842-200203000-00007
更新日期:2002-03-01 00:00:00
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doi:10.1097/psy.0b013e31806bf365
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199905000-00009
更新日期:1999-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000169
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doi:10.1097/PSY.0b013e3182689460
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journal_title:Psychosomatic medicine
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197601000-00003
更新日期:1976-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To focus on the relationship between pregnancy-related anxiety and spontaneous preterm birth. Psychosocial factors have been the subject of inquiries about the etiology of preterm birth; a factor of recent interest is maternal prenatal pregnancy-related anxiety (worries and concerns related to the pregnancy)....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3180cac25d
更新日期:2007-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198707000-00011
更新日期:1987-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198011000-00003
更新日期:1980-11-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/PSY.0b013e3182546f18
更新日期:2012-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199705000-00012
更新日期:1997-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000258
更新日期:2016-02-01 00:00:00