Abstract:
OBJECTIVE:To examine the potential moderating role of DRD2 polymorphism (rs1800497) in the association between stressful life events and depressive symptoms among young adults. Although stressful life events, such as divorce, unemployment, and serious illness in the family, are generally associated with negative health outcomes, including depressive symptoms, there are large individual differences in coping with such events. A number of studies suggest that variants in dopamine receptor genes, such as DRD2, are associated with depression but it is unclear if such variants also modify the association between life events and depression. METHODS:We analyzed the prospective data on life events and depressive symptoms in 1992 and 2001 related to 1611 young adults (672 men and 939 women, aged 15-30 years at baseline) who participated in the ongoing population-based cardiovascular risk in young Finns study. RESULTS:Occurrence of stressful life events was associated with increased risk of subsequent depressive symptoms in men and women. However, this association was seen only among those who carried A2/A2 (n = 872) genotype. No such association was detected in participants carrying A1/A1 or A1/A2 (n = 486) genotype. CONCLUSION:DRD2 polymorphism moderates the effect of stressful life events on depressive symptoms and those who carry A2/A2 DRD2 genotypes may be more vulnerable than others.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Elovainio M,Jokela M,Kivimäki M,Pulkki-Råback L,Lehtimäki T,Airla N,Keltikangas-Järvinen Ldoi
10.1097/psy.0b013e31806bf365subject
Has Abstractpub_date
2007-06-01 00:00:00pages
391-5issue
5eissn
0033-3174issn
1534-7796pii
69/5/391journal_volume
69pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to examine the association between psychobiological stress reactivity during healthy pregnancy and depressive symptoms in the early puerperium. METHODS:A sample of healthy nulliparous pregnant women (N = 57) between the ages of 21 and 35 years underwent a standardized psychosoci...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000244385.93141.3b
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:Altered autonomic nervous system activity is considered to be involved in the pathophysiology of somatic symptom disorder (SSD). This study aimed to investigate whether patients with SSD have disturbed autonomic activity during rest and reactivity to emotional processing and whether altered autonomic nervous ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000622
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects. It is still unclear whether these changes are truly specific to pain and not related to general changes in somatosensory functions. The aim of the present study was to evaluate the effect o...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000145912.24553.c0
更新日期:2004-11-01 00:00:00
abstract::Three studies on the relationship between life stresses and premature labor were conducted. The first was a retrospective comparison of life events between a group of women who had had premature labor and a group of controls. It was carried out between 3 and 6 months after the premature delivery to neutralize possible...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198605000-00006
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:Cancer-related distress due to the psychological and physical challenges of metastatic breast cancer (MBC) may result in symptoms of depression, which negatively affects quality and may influence quantity of life. This study investigated how depression affects MBC stress reactivity, including autonomic (ANS) ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000238216.88515.e5
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To study the sociocultural transformation of neurasthenia (shenjing shuairuo, SJSR), as both disease and illness, in Chinese society. METHOD:This is based on a critical review of evidence drawn from the psychiatric and anthropological literature, and the use of a single case study. RESULTS:SJSR remains a ub...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/00006842-199807000-00010
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:To test associations between heart rate variability (HRV), depressed mood, and positive affect in patients with suspected coronary artery disease (CAD). Depression is associated with impaired HRV post acute cardiac events, but evidence in patients with stable coronary artery disease (CAD) is inconsistent. ME...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/PSY.0b013e318189afcc
更新日期:2008-11-01 00:00:00
abstract::Patients who underwent repetitive repetitive coronary angiograms at an average interval of 17 months completed the Jenkins Activity Survey (n = 66) and were given the Rosenman diagnostic interview to measure Type A behavior (n = 45). Significant progression of coronary artery disease was judged to be an increase in oc...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197910000-00003
更新日期:1979-10-01 00:00:00
abstract::A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance ...
journal_title:Psychosomatic medicine
pub_type: 评论,社论
doi:10.1097/PSY.0000000000000373
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:An attachment model was used to understand how maternal sensitivity and adverse childhood experiences are related to somatization. METHODS:We examined maternal sensitivity at 6 and 18 months and somatization at 5 years in 292 children in a longitudinal cohort study. We next examined attachment insecurity and...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000437
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To determine whether the relationship between interleukin (IL)-6 and depressive symptoms is moderated by participation in moderate-intensity physical activity in a sample of primary care patients. Elevated inflammation has been associated with a number of poor health outcomes. Depressive symptoms may be relat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182108412
更新日期:2011-04-01 00:00:00
abstract::The differential relationship between specific subtypes of premenstrual changes and specific subtypes of mental disorder was studied. Premenstrual changes were evaluated with the Premenstrual Assessment Form, which provides specific criteria for the classification of the various subtypes of premenstrual change. The Re...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198112000-00008
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVES:To examine associations between intelligence and psychomotor coordination in childhood and risk of psychological distress, poorer self-rated health, and obesity in adulthood. To investigate whether psychomotor coordination as a potential marker of the construct "system integrity" explains associations betwee...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181a63b2e
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To investigate efficacy and safety of St. John's wort (SJW) LI 160 in somatoform disorders. METHODS:In a prospective, randomized, placebo-controlled, and double-blind parallel group study, 184 outpatients with somatization disorder (ICD-10 F45.0), undifferentiated somatoform disorder (F45.1), and somatoform ...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000128900.13711.5b
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:The new DSM-5 somatic symptom disorder was introduced to improve the diagnosis of persons experiencing what used to be called somatoform disorders. So far, it is unclear whether existing self-report measures are useful to detect the new somatic symptom disorder. This study investigates the diagnostic accuracy...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000530
更新日期:2017-11-01 00:00:00
abstract::This investigation assessed the syndromal nature of menstrual cycle changes in women who experience significant cyclicity of mood by exploring the time course of different symptoms in relation to endocrinologically defined segments of the menstrual cycle. Participants were accepted into the protocol on the basis of a ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198903000-00007
更新日期:1989-03-01 00:00:00
abstract::Recent technologic advances have permitted the observation of rapid and significant increases in blood pressure (BP) during verbal communication. The magnitude of the increase in BP is influenced by rate of speech, audience size, status, affective content, environmental setting, and resting BP. The current study evalu...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198601000-00008
更新日期:1986-01-01 00:00:00
abstract::Earlier studies suggest that cardiovascular responses in the laboratory and in the field are likely to be related when the laboratory tasks involve active coping, when the field measure is taken continuously, and when there is allowance for the effects of autocorrelation and physical activity on the ambulant cardiovas...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199407000-00013
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:Increased cerebral blood flow during processing of acute pain has repeatedly been observed in fibromyalgia syndrome. The study investigated the time dynamics of the pain-related hemodynamic response in fibromyalgia using transcranial Doppler sonography. METHODS:In 25 women with fibromyalgia and 25 healthy p...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182676d08
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To examine whether increased sleep during viral or bacterial infections supports host defense mechanisms. METHODS:To test this assumption in humans, healthy male subjects were assigned either to sleep from 2300 to 0700 hours (n = 10) or to stay awake through the night (n = 10). In the sleeping subjects Salmo...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-200107000-00008
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:Ambulatory saliva collections for subsequent analysis of free cortisol levels are now frequently applied to measure adrenocortical activity in healthy subjects and patient populations. Despite the prime importance of accurate timing of saliva collection outside the laboratory, no data are available on the com...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000058374.50240.bf
更新日期:2003-03-01 00:00:00
abstract::Thirty normal-weight female bulimics were followed up 2-5 years following hospital admission using semistructured interviews and psychometric measures. Inasmuch as bulimia was only recently designated a distinct disorder, questions have emerged with regard to its clinical course and diagnostic validity. Results of thi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198701000-00004
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:The John Henryism hypothesis proposes that high-effort, active coping in impoverished, low-resource environments is associated with an increased risk of cardiovascular disease, but a lower risk of disease in a high-resource environment. To test this hypothesis, we examined the association of John Henryism Act...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000308
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To examine whether high-frequency heart rate variability, an indirect measure of parasympathetic (vagal) control over variations in heart rate, is associated with immune reactivity to an in vitro inflammatory challenge. Convergent evidence from the animal literature shows that the autonomic nervous system pla...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181576118
更新日期:2007-11-01 00:00:00
abstract::A multidimensional behavioral program was developed for the treatment of essential hypertension. Over a course of 6 weeks, 108 patients of a rehabilitation center were treated with this program consisting of health education, self-monitoring of blood pressure, relaxation techniques, and a social skill training in addi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198707000-00011
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVES:To hypothesize in a new and different population that administrative database (ADB) screening would identify somatizing patients by increasing numbers of visits, female gender, and greater percent of International Classification of Diseases, 9th Edition (ICD-9) primary diagnosis codes in musculoskeletal, ner...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31819cc783
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To examine longitudinal bidirectional associations between two depressive symptom clusters-the cognitive-affective and somatic-vegetative clusters--and insulin resistance, a marker of prediabetes. METHODS:Participants were 269 adults aged 50 to 70 years without diabetes enrolled in the Pittsburgh Healthy Hea...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000063
更新日期:2014-06-01 00:00:00
abstract::Plasma levels of luteinizing hormone (LH) and testosterone were determined by radioimmunoassay in medical students just before (Exp. 1) and after (Exp. 2) an academic examination and corresponding control periods. Before the examination (Exp. 1), the males' LH values were lower than their control levels, but there was...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198805000-00006
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:Increased depressive symptoms have been associated with increased basal plasma norepinephrine (NE), and may be associated with exaggerated NE response to stress. This exaggerated response may play a role in health consequences associated with caring for a loved-one with Alzheimer's disease. The current study ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000173312.90148.97
更新日期:2005-07-01 00:00:00
abstract::Negative affectivity (NA) and repressive coping (REP) are coping styles characterized by a disposition to either experience or avoid distress. This study investigated the potential influence of NA and REP on self-reported distress and coronary-prone behavior among 178 male cardiac patients undergoing rehabilitation. B...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199109000-00005
更新日期:1991-09-01 00:00:00