Treatment of somatoform disorders with St. John's wort: a randomized, double-blind and placebo-controlled trial.


OBJECTIVE:To investigate efficacy and safety of St. John's wort (SJW) LI 160 in somatoform disorders. METHODS:In a prospective, randomized, placebo-controlled, and double-blind parallel group study, 184 outpatients with somatization disorder (ICD-10 F45.0), undifferentiated somatoform disorder (F45.1), and somatoform autonomic dysfunction (F45.3), but not major depression, received either 300 mg of SJW extract LI 160 twice daily or matching placebo for 6 weeks. Six outcome measures were evaluated as a combined measure by means of the Wei Lachin test: Somatoform Disorders Screening Instrument--7 days (SOMS-7), somatic subscore of the HAMA, somatic subscore of the SCL-90-R, subscores "improvement" and "efficacy" of the CGI, and the global judgment of efficacy by the patient. RESULTS:In the intention to treat population (N=173), for each of the six primary efficacy measures as well as for the combined test, statistically significant medium to large-sized superiority of SJW treatment over placebo was demonstrated (p <.0001). Of the SJW patients, 45.4% were classified as responders compared with 20.9% with placebo (p =.0006). Tolerability of SJW treatment was equivalent to placebo. CONCLUSIONS:Administration of 600 mg of SJW extract LI 160 daily is effective and safe in the treatment of somatoform disorders, thereby confirming results from a previous study.


Psychosom Med


Psychosomatic medicine


Müller T,Mannel M,Murck H,Rahlfs VW




Has Abstract


2004-07-01 00:00:00














  • Are stress-induced cortisol changes during pregnancy associated with postpartum depressive symptoms?

    abstract:OBJECTIVE:The purpose of this study was to examine the association between psychobiological stress reactivity during healthy pregnancy and depressive symptoms in the early puerperium. METHODS:A sample of healthy nulliparous pregnant women (N = 57) between the ages of 21 and 35 years underwent a standardized psychosoci...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Nierop A,Bratsikas A,Zimmermann R,Ehlert U

    更新日期:2006-11-01 00:00:00

  • Intimate partner violence and mental health consequences in women attending family practice in Spain.

    abstract:OBJECTIVE:Despite the abundant literature on the consequences of intimate partner violence (IPV) on mental health, psychological abuse has rarely been considered, and the separate effects of the different types of IPV have been understudied. The aim of this study was to analyze the association between physical, psychol...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Ruiz-Pérez I,Plazaola-Castaño J

    更新日期:2005-09-01 00:00:00

  • Depression and risk of heart failure among the elderly: a prospective community-based study.

    abstract:OBJECTIVE:Although the association between depression and the incidence of coronary heart disease has been established in many studies, the impact of depression on the incidence of heart failure has not been previously investigated. METHODS:We examined the effect of depression (assessed by means of the Center for Epid...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Williams SA,Kasl SV,Heiat A,Abramson JL,Krumholz HM,Vaccarino V

    更新日期:2002-01-01 00:00:00

  • Cardiovascular effects of social support in the work place: twenty-four-hour ECG monitoring of men and women.

    abstract::Psychosocial work characteristics, such as work demand, work control, and social support at work, have been shown to be related to the development of coronary heart disease in epidemiological studies. However, the mechanisms which mediate the social and psychological effects on the cardiovascular system are not known....

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Undén AL,Orth-Gomér K,Elofsson S

    更新日期:1991-01-01 00:00:00

  • Effects of age and gender on the relationship between anxiety and coronary artery disease.

    abstract::This study investigated the relationship between anxiety and coronary artery disease (CAD). State (S-ANX) and trait (T-ANX) anxiety were assessed with the State-Trait Personality Inventory (STPI), which was administered to 373 patients (230 males, 143 females) 12 to 18 hr prior to their undergoing coronary arteriograp...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Schocken DD,Greene AF,Worden TJ,Harrison EE,Spielberger CD

    更新日期:1987-03-01 00:00:00

  • Intrusion, avoidance, and psychological distress among individuals with cancer.

    abstract:OBJECTIVE:The goal of the study was to examine the utility of Creamer's cognitive processing theory of trauma in a sample of individuals undergoing treatment for cancer. This theory proposes that avoidance is a maladaptive strategy of dealing with intrusive thoughts about a traumatic experience and suggests that avoida...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Manne S,Glassman M,Du Hamel K

    更新日期:2001-07-01 00:00:00

  • Exhaustion is associated with low macrophage migration inhibitory factor expression in patients with coronary artery disease.

    abstract:OBJECTIVE:Macrophage migration inhibitory factor (MIF), a protein secreted by immune cells and the pituitary gland, may be associated with coronary artery disease (CAD) and the mental state of coronary patients. The first origin of MIF suggests positive, the second negative associations. The aim of this study was to ex...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kwaijtaal M,van der Ven AJ,van Diest R,Bruggeman CA,Bär FW,Calandra T,Appels A,Sweep FC

    更新日期:2007-01-01 00:00:00

  • Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening.

    abstract:OBJECTIVE:There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the cortisol response during the first hour in the morning with strict reference to the time of awakening was established as a reliable marker of individual adrenocortical activ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Pruessner M,Hellhammer DH,Pruessner JC,Lupien SJ

    更新日期:2003-01-01 00:00:00

  • Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.

    abstract:OBJECTIVE:The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS:One hundred sixty adults (M [SD] = 65.4 [6.8] years) with CIND completed neurocognitive assessments of ex...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Blumenthal JA,Smith PJ,Mabe S,Hinderliter A,Welsh-Bohmer K,Browndyke JN,Lin PH,Kraus W,Doraiswamy PM,Burke J,Sherwood A

    更新日期:2017-07-01 00:00:00

  • Longitudinal follow-up of amenorrhea in eating disorders.

    abstract::The authors recruited 229 treatment-seeking anorexic and bulimic women for a prospective, longitudinal study. Telephone interviews were arranged every 3 months for at least 1 year for 225 patients. At intake, 132 subjects were menstruating, 34 subjects were taking oral contraceptives, 5 subjects had an organic cause f...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Copeland PM,Sacks NR,Herzog DB

    更新日期:1995-03-01 00:00:00

  • History of modern psychopharmacology: a personal view with an emphasis on antidepressants.

    abstract:OBJECTIVE:This article provides the chemical basis for the molecular modification of H1 antihistamines in the rational development of some antidepressant and antipsychotic drugs. METHODS:A review of the literature and personal experiences have been compiled. CONCLUSIONS:The contributions of many basic scientists, the...

    journal_title:Psychosomatic medicine

    pub_type: 历史文章,杂志文章


    authors: Domino EF

    更新日期:1999-09-01 00:00:00

  • Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability.

    abstract:OBJECTIVE:To examine whether high-frequency heart rate variability, an indirect measure of parasympathetic (vagal) control over variations in heart rate, is associated with immune reactivity to an in vitro inflammatory challenge. Convergent evidence from the animal literature shows that the autonomic nervous system pla...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Marsland AL,Gianaros PJ,Prather AA,Jennings JR,Neumann SA,Manuck SB

    更新日期:2007-11-01 00:00:00

  • Increased risks of acute organ dysfunction and mortality in intensive care unit patients with schizophrenia: a nationwide population-based study.

    abstract:OBJECTIVE:To investigate the risks of acute organ dysfunction and death in intensive care unit (ICU) patients with schizophrenia. METHODS:Using a retrospective matched cohort design, we compared 203 schizophrenic patients to 2036 demographically matched (1:10) nonschizophrenic patients with first-time ICU admission be...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Shen HN,Lu CL,Yang HH

    更新日期:2011-09-01 00:00:00

  • Serotonergic changes in specific areas of rat brain associated with activity--stress gastric lesions.

    abstract::To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected t...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Hellhammer DH,Hingtgen JN,Wade SE,Shea PA,Aprison MH

    更新日期:1983-05-01 00:00:00

  • Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder.

    abstract:OBJECTIVE:The thermal grill illusion (TGI) in which interlacing cold and warm bars create the illusion of a painful sensation has been suggested as an experimental model for central pain states and pain processing. The aim of this study was to use this technique to gain further insights into the altered pain perception...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Boettger MK,Grossmann D,Bär KJ

    更新日期:2013-04-01 00:00:00

  • Association between self-reported dental health status and onset of dementia: a 4-year prospective cohort study of older Japanese adults from the Aichi Gerontological Evaluation Study (AGES) Project.

    abstract:OBJECTIVES:Studies have shown that people with cognitive impairment have poor dental health. However, the direction of causality remains unknown. This prospective cohort study aimed to determine the association between four self-reported dental health variables and dementia onset in older Japanese people. METHODS:Anal...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Yamamoto T,Kondo K,Hirai H,Nakade M,Aida J,Hirata Y

    更新日期:2012-04-01 00:00:00

  • Does anxiety affect risk of dementia? Findings from the Caerphilly Prospective Study.

    abstract:OBJECTIVE:To examine the association of anxiety with incident dementia and cognitive impairment not dementia (CIND). METHODS:We conducted a prospective study of men aged 48 to 67 years at baseline anxiety assessment; we measured cognition 17 years later. We studied 1481 men who were either eligible for examination or ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Gallacher J,Bayer A,Fish M,Pickering J,Pedro S,Dunstan F,Ebrahim S,Ben-Shlomo Y

    更新日期:2009-07-01 00:00:00

  • Validation of the Women's Health Initiative Insomnia Rating Scale in a multicenter controlled clinical trial.

    abstract:OBJECTIVE:The objective of this study was to evaluate the construct validity of the five-item Women's Health Initiative Insomnia Rating Scale (WHIIRS) by comparing women taking hormone therapy (HT) versus those taking a placebo and by comparing women known to differ in vasomotor symptoms. METHODS:The WHIIRS was includ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Levine DW,Dailey ME,Rockhill B,Tipping D,Naughton MJ,Shumaker SA

    更新日期:2005-01-01 00:00:00

  • The relation between dominance, anger, and hormones in normally aging men: results from the Massachusetts Male Aging Study.

    abstract::This paper examines the relation of two personality characteristics (dominance and anger) to hormones in normally aging men. The relation of the Jackson Personality Research Form E Dominance subscale and the Spielberger Anger Expression scale to serum levels of 17 endocrine variables, including testosterone (T) and di...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Gray A,Jackson DN,McKinlay JB

    更新日期:1991-07-01 00:00:00

  • Structural and electrical myocardial remodeling in a rodent model of depression.

    abstract:OBJECTIVE:Despite a well-documented association between stress and depression with cardiac morbidity and mortality, there is no satisfactory explanation for the mechanisms linking affective and cardiac disorders. This study investigated cardiac electrophysiological properties in an animal model of depression. METHODS:...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Carnevali L,Trombini M,Rossi S,Graiani G,Manghi M,Koolhaas JM,Quaini F,Macchi E,Nalivaiko E,Sgoifo A

    更新日期:2013-01-01 00:00:00

  • Monitoring for sleep-related threat: a pilot study of the Sleep Associated Monitoring Index (SAMI).

    abstract:OBJECTIVE:The aims of this pilot study were: 1) to establish the reliability and validity of a new self-report instrument designed to index monitoring for sleep-related threat; 2) to determine the presence of ten monitoring types proposed in a recent cognitive model of insomnia and to examine the relationship between m...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Semler CN,Harvey AG

    更新日期:2004-03-01 00:00:00

  • Psychiatric Disorders and Weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up.

    abstract:OBJECTIVES:To document changes in Axis I psychiatric disorders after bariatric surgery and examine their relationship with postsurgery weight loss. METHODS:As part of a three-site substudy of the Longitudinal Assessment of Bariatric Surgery Research Consortium, 199 patients completed the Structured Clinical Interview ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Kalarchian MA,King WC,Devlin MJ,Marcus MD,Garcia L,Chen JY,Yanovski SZ,Mitchell JE

    更新日期:2016-04-01 00:00:00

  • Personality characteristics, body image and social attitudes of organ transplant donors versus nondonors.

    abstract::Thirty adults willing their body at death to medical science were compared on a number of personality variables with 30 nondonors, both groups equated for age, education, and socioeconomic status. Donors are internally directed, masters of their fate; nondonors rely on chance or luck to explain outcome. A more defin...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Cleveland SE

    更新日期:1975-07-01 00:00:00

  • Smoking status and nicotine administration differentially modify hemodynamic stress reactivity in men and women.

    abstract:OBJECTIVES:To investigate the impact of cigarette smoking and oral contraceptive (OC) use on hemodynamic stress responses of women. Also, to examine gender differences in stress reactivity as a function of smoking status and acute nicotine administration. METHODS:Thirty men and 46 women, differing in smoking status an...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Girdler SS,Jamner LD,Jarvik M,Soles JR,Shapiro D

    更新日期:1997-05-01 00:00:00

  • Depression predicts revascularization procedures for 5 years after coronary angiography.

    abstract:OBJECTIVE:Depression has been reported to increase cardiac event rates and functional impairment in patients with coronary disease. This article describes the impact of depression on subsequent healthcare utilization for such patients. METHODS:One hundred ninety-eight health maintenance organization patients with stab...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Sullivan MD,LaCroix AZ,Spertus JA,Hecht J,Russo J

    更新日期:2003-03-01 00:00:00

  • Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women.

    abstract:OBJECTIVE:Brain-gut-microbiota interactions may play an important role in human health and behavior. Although rodent models have demonstrated effects of the gut microbiota on emotional, nociceptive, and social behaviors, there is little translational human evidence to date. In this study, we identify brain and behavior...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Tillisch K,Mayer EA,Gupta A,Gill Z,Brazeilles R,Le Nevé B,van Hylckama Vlieg JET,Guyonnet D,Derrien M,Labus JS

    更新日期:2017-10-01 00:00:00

  • Mismatch in Spouses' Anger-Coping Response Styles and Risk of Early Mortality: A 32-Year Follow-Up Study.

    abstract:OBJECTIVE:Research in psychosomatic medicine includes a long history of studying how responses to anger-provoking situations are associated with health. In the context of a marriage, spouses may differ in their anger-coping response style. Where one person may express anger in response to unfair, aggressive interperson...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Bourassa KJ,Sbarra DA,Ruiz JM,Karciroti N,Harburg E

    更新日期:2019-01-01 00:00:00

  • Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation.

    abstract:OBJECTIVE:Numerous theories have proposed that acute and chronic stressors may exert a cumulative effect on life-span health by causing biological "wear and tear," or allostatic load, which in turn promotes disease. Very few studies have directly tested such models, though, partly because of the challenges associated w...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Slavich GM,Shields GS

    更新日期:2018-01-01 00:00:00

  • Negative behavior during marital conflict is associated with immunological down-regulation.

    abstract::Although increased morbidity and mortality have been reliably associated with social isolation and less satisfying personal relationships, relatively little is known about the underlying biopsychosocial mechanisms. We assessed problem-solving behaviors and changes in immune function in 90 newlywed couples who were adm...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Kiecolt-Glaser JK,Malarkey WB,Chee M,Newton T,Cacioppo JT,Mao HY,Glaser R

    更新日期:1993-09-01 00:00:00

  • Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder.

    abstract:OBJECTIVE:Trauma is associated with increased risk for anxiety disorders such as posttraumatic stress disorder (PTSD). To further understand biologic mechanisms of PTSD, we examined the dark-enhanced startle response, a psychophysiological correlate of anxiety, and heart rate variability (HRV) in traumatized individual...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Kamkwalala A,Norrholm SD,Poole JM,Brown A,Donley S,Duncan E,Bradley B,Ressler KJ,Jovanovic T

    更新日期:2012-02-01 00:00:00