Treatment of somatoform disorders with St. John's wort: a randomized, double-blind and placebo-controlled trial.

Abstract:

OBJECTIVE:To investigate efficacy and safety of St. John's wort (SJW) LI 160 in somatoform disorders. METHODS:In a prospective, randomized, placebo-controlled, and double-blind parallel group study, 184 outpatients with somatization disorder (ICD-10 F45.0), undifferentiated somatoform disorder (F45.1), and somatoform autonomic dysfunction (F45.3), but not major depression, received either 300 mg of SJW extract LI 160 twice daily or matching placebo for 6 weeks. Six outcome measures were evaluated as a combined measure by means of the Wei Lachin test: Somatoform Disorders Screening Instrument--7 days (SOMS-7), somatic subscore of the HAMA, somatic subscore of the SCL-90-R, subscores "improvement" and "efficacy" of the CGI, and the global judgment of efficacy by the patient. RESULTS:In the intention to treat population (N=173), for each of the six primary efficacy measures as well as for the combined test, statistically significant medium to large-sized superiority of SJW treatment over placebo was demonstrated (p <.0001). Of the SJW patients, 45.4% were classified as responders compared with 20.9% with placebo (p =.0006). Tolerability of SJW treatment was equivalent to placebo. CONCLUSIONS:Administration of 600 mg of SJW extract LI 160 daily is effective and safe in the treatment of somatoform disorders, thereby confirming results from a previous study.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Müller T,Mannel M,Murck H,Rahlfs VW

doi

10.1097/01.psy.0000128900.13711.5b

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

538-47

issue

4

eissn

0033-3174

issn

1534-7796

pii

66/4/538

journal_volume

66

pub_type

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