Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.

Abstract:

:A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance of shorter telomeres, this editorial describes mechanistic pathways that lead to telomere shortening. Additionally, two other novel methods for measuring biological markers of accelerated aging are briefly discussed: DNA methylation and cellular senescence based on p16. These innovative approaches could be used to confirm and extend our understanding of psychiatric patients' increased health and mortality risks.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Kiecolt-Glaser JK,Wilson SJ

doi

10.1097/PSY.0000000000000373

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

772-5

issue

7

eissn

0033-3174

issn

1534-7796

journal_volume

78

pub_type

评论,社论
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