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Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability.

Abstract：

OBJECTIVE:To examine whether high-frequency heart rate variability, an indirect measure of parasympathetic (vagal) control over variations in heart rate, is associated with immune reactivity to an in vitro inflammatory challenge. Convergent evidence from the animal literature shows that the autonomic nervous system plays a key role in regulating the magnitude of immune responses to inflammatory stimuli. Signaling by the parasympathetic system inhibits the production of proinflammatory cytokines by activated monocytes/macrophages and thus decreases local and systemic inflammation. As yet, no direct human evidence links parasympathetic activity to inflammatory competence. METHODS:We examined the relationship of variations in heart rate, recorded during paced respiration, to lipopolysaccharide-induced production of the inflammatory cytokines interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and IL-10 among a community sample of 183 healthy adults (mean age = 45 years; 59% male; 92% White, 7% African-American). RESULTS:Consistent with animal findings, higher derived estimates of vagal activity measured during paced respiration were associated with lower production of the proinflammatory cytokines TNF-alpha and IL-6 (r = -.18 to -.30), but were not related to production of the anti-inflammatory cytokine IL-10. These associations persisted after controlling for demographic and health characteristics, including age, gender, race, years of education, smoking, hypertension, and white blood cell count. CONCLUSIONS:These data provide initial human evidence that vagal activity is inversely related to inflammatory competence, raising the possibility that vagal regulation of immune reactivity may represent a pathway linking psychosocial factors to risk for inflammatory disease.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Marsland AL,Gianaros PJ,Prather AA,Jennings JR,Neumann SA,Manuck SB

doi

10.1097/PSY.0b013e3181576118

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

709-16

issue

8

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3181576118

journal_volume

69

pub_type

杂志文章

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