Abstract:
OBJECTIVE:To test whether depressive symptoms are related to inflammatory and hemostatic markers in women approaching menopause. METHODS:A total of 3292 women enrolled in the Study of Women's Health Across the Nation (SWAN) were followed for five years and had measures of Center for Epidemiologic Studies-Depression and high sensitivity C-reactive protein, Factor VIIc, fibrinogen, plasminogen activator inhibitor Type 1(PAI-1), and tissue-type plasminogen activator antigen (tPA-ag) up to four times during the follow-up period. Women were pre- or early perimenopausal status at study entry and were of Caucasian, African American, Hispanic, Japanese, or Chinese race/ethnicity. RESULTS:Unadjusted longitudinal mixed regression models showed that over a 5-year period, higher depressive symptoms were related to higher fibrinogen, PAI-1, and tPA-ag levels, all p < .0001. Taking into account health history, medication use, ethnicity, aging, and menopausal status, the depressive symptoms were related to fibrinogen, p < .01, and PAI-1, p < .05. Depressive symptoms were related only to fibrinogen in models that also included body mass index, p < .05. CONCLUSIONS:Depressive symptoms may be associated with cardiovascular risk in perimenopausal women in part through hypercoagulability. This is the first study to test the association of depressive symptoms and hemostatic and inflammatory markers across time.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Matthews KA,Schott LL,Bromberger J,Cyranowski J,Everson-Rose SA,Sowers MFdoi
10.1097/01.psy.0000256574.30389.1bsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
124-30issue
2eissn
0033-3174issn
1534-7796pii
01.psy.0000256574.30389.1bjournal_volume
69pub_type
杂志文章abstract:OBJECTIVE:Persons with elevated blood pressure (BP) show dampened emotional responses to affect-laden stimuli. We sought to further examine cardiovascular-emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African American community-based sample....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318235ed55
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD). METHODS:Patients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000776
更新日期:2020-04-01 00:00:00
abstract::The Adolescent Structured Interview (ASI), adapted from the interview that assesses Type A behavior of adults, was administered to 204 adolescents. These adolescents also completed a battery of self-report questionnaires that measured the three major components of Pattern A: competitive achievement-striving, speed and...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198108000-00004
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVE:This article provides the chemical basis for the molecular modification of H1 antihistamines in the rational development of some antidepressant and antipsychotic drugs. METHODS:A review of the literature and personal experiences have been compiled. CONCLUSIONS:The contributions of many basic scientists, the...
journal_title:Psychosomatic medicine
pub_type: 历史文章,杂志文章
doi:10.1097/00006842-199909000-00002
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:Patients' expectations have been shown to predict the course and treatment success of a variety of medical conditions. Therefore, expectation-focused psychological interventions (EFPIs) have been developed to use these expectation effects clinically. Importantly, EFPI differ with regard to the particular expe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000596
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:In this case study, we describe the effects of a particular individual's concentration/meditation technique on autonomic nervous system activity and the innate immune response. The study participant holds several world records with regard to tolerating extreme cold and claims that he can influence his autonom...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182583c6d
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:This study was conducted to confirm the definition of multiple chemical sensitivity (MCS) in actual life: that multiple symptoms are provoked in multiple organs by exposure to, and ameliorated by avoidance of, multiple chemicals at low levels. We used the Ecological Momentary Assessment to monitor everyday sy...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000155676.69030.28
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:To document changes in Axis I psychiatric disorders after bariatric surgery and examine their relationship with postsurgery weight loss. METHODS:As part of a three-site substudy of the Longitudinal Assessment of Bariatric Surgery Research Consortium, 199 patients completed the Structured Clinical Interview ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000277
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:Numerous studies have found elevated depressive symptoms among individuals with Type 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict depressive symptoms among overweight/obese individuals with Type 2 diabetes or change in ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/PSY.0000000000000242
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Research in psychosomatic medicine includes a long history of studying how responses to anger-provoking situations are associated with health. In the context of a marriage, spouses may differ in their anger-coping response style. Where one person may express anger in response to unfair, aggressive interperson...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000653
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Depression in adults is associated with risk factors for cardiovascular disease (CVD). It is unclear, however, when the association between clinical depression and cardiac risk factors develops or how early in life this association can be detected. METHODS:In an ongoing study of pediatric depression, we comp...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000028
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The interplay between depression and socioeconomic position (SEP) in predicting cardiovascular outcomes has rarely been examined. We investigated whether SEP modified the effect of antidepressant use on coronary heart disease (CHD) mortality. METHODS:The data consisted of an 11% random sample of the Finnish ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000258
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:Two important determinants of physiological stress responses have been identified, uncontrollability of the stressor and amount of effort involved in coping with the stressor. In the present experiment, we tried to identify the specific contributions of effort and uncontrollability to immune system responses ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199907000-00016
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the evidence for an association between cesarean section and postpartum depression. METHODS:Medline and PsychInfo databases were searched. All studies on cesarean section that evaluated maternal mood between 10 days and 1 year after delivery were reviewed. Nine meth...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/01.psy.0000204787.83768.0c
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:This study examined pituitary-adrenocortical responses to dietary doses of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee), alone and combined with behavioral stress, in men at high risk versus low risk for hypertension. A randomized, double-blind, caffeine-placebo crossover design was used. METHOD...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199807000-00021
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:To investigate the association between vitamin D deficiency and depressive symptoms in a national community sample of older people. Vitamin D deficiency is common in older people with potential effects on mood. METHODS:Data were analyzed from 2070 participants aged ≥65 years who had participated in the 2005 ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181e9bf15
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Autonomic nervous system activity is associated with neurobehavioral aspects of pain. Yogis use breathing, relaxation, and mindfulness to tolerate pain, which could influence autonomic responses. To evaluate how the link between autonomic responses and pain is altered by other factors, we compared perceptual ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000587
更新日期:2018-11-01 00:00:00
abstract::The plasma cholesterol levels of 279 students were measured and related to decision and movement times in choice reaction time tasks with one, two, four, and eight lamps. In female subjects, low plasma cholesterol levels were associated with slower movement times and, when responding to one or two lamps, slower decisi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199501000-00008
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:Exposure is regarded to be a crucial component of therapies for phobias. According to emotional processing theory, the success of exposure therapy is predicted by activation of subjective and physiological fear responses and their within-session habituation and between-session adaptation. This study tested t...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000209
更新日期:2015-09-01 00:00:00
abstract::Depression is a well-known reaction to separation in all species of macaques studied except the bonnet (M. radiata), in whom this reaction has never before been observed. We have produced the depressive response of postural collapse and social withdrawal in a bonnet infant by altering the social structure of the group...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197802000-00008
更新日期:1978-02-01 00:00:00
abstract:OBJECTIVE:Although considerable evidence implicates hostility in the development of coronary artery disease (CAD), the pathogenic mechanisms remain poorly understood. We have developed a psychophysiological model that holds that altered autonomic nervous system function links psychological traits with CAD outcomes. In ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200105000-00012
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:Somatic symptom disorder (SSD) often co-occurs with major depressive disorder (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional brain connectivity betwee...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000490
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To investigate differences in social problem solving (SPS) between individuals with noncardiac chest pain (NCCP) and persons with chest pain who tested positive for underlying cardiac disease. METHODS:The major design involved a matched case-control methodology and compared a group of patients with NCCP (n =...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31815a995a
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:Lesbian, gay, and bisexual (LGB) individuals-particularly those who have not disclosed their sexual orientation-are believed to experience increased chronic stress in comparison with heterosexuals. This interdisciplinary study assessed whether psychiatric symptoms (self-rated anxiety, depression, and burnout...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182826881
更新日期:2013-02-01 00:00:00
abstract::The study of depression in cancer patients has been hampered by difficulty in establishing diagnostic criteria, since neurovegetative signs and symptoms may be attributable either to depression or physical illness. Confusion has also arisen in defining the boundary between "normal" grieving with illness, and "abnormal...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198405000-00002
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVES:To review the relevance of cultural models in the generation and amplification of somatic symptoms and syndromes. METHODS:Based on a selective review of literature, we examine evidence that cultural and personal explanatory models can contribute to the pathogenesis, symptomatology, and chronicity of medical...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/PSY.0b013e31815b002c
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:The two objectives are to test the hypothesis that women in a profession with low decision latitude will have greater catecholamine excretion and higher blood pressure than women in a profession with greater decision latitude, and to assess the influence of ethnicity on the occupational comparison. METHODS:...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000222356.71315.8e
更新日期:2006-07-01 00:00:00
abstract::This study examines the effectiveness of an intervention for minor depression in primary care patients. One hundred fifty public care medical patients were randomly assigned to either an 8-week cognitive-behavioral course intended to help them use pleasant activities, constructive thinking, and interpersonal relations...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199403000-00009
更新日期:1994-03-01 00:00:00
abstract::Negative affectivity (NA) and repressive coping (REP) are coping styles characterized by a disposition to either experience or avoid distress. This study investigated the potential influence of NA and REP on self-reported distress and coronary-prone behavior among 178 male cardiac patients undergoing rehabilitation. B...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199109000-00005
更新日期:1991-09-01 00:00:00
abstract::A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance ...
journal_title:Psychosomatic medicine
pub_type: 评论,社论
doi:10.1097/PSY.0000000000000373
更新日期:2016-09-01 00:00:00