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The association between major depressive disorder in childhood and risk factors for cardiovascular disease in adolescence.

Abstract：

OBJECTIVE:Depression in adults is associated with risk factors for cardiovascular disease (CVD). It is unclear, however, when the association between clinical depression and cardiac risk factors develops or how early in life this association can be detected. METHODS:In an ongoing study of pediatric depression, we compared CVD risk factors including smoking, obesity, physical activity level, sedentary behavior, and parental history of CVD across three samples of adolescents: probands with established histories of childhood-onset major depressive disorder (n = 210), never-depressed siblings of probands (n = 195), and controls with no history of any major psychiatric disorder (n = 161). RESULTS:When assessed during adolescence, 85% of the probands were not in a major depressive episode. Nevertheless, at that assessment, probands had a higher prevalence of regular smoking (odds ratio [OR] = 12.54, 95% confidence interval [CI] = 4.36-36.12) and were less physically active than controls (OR = 0.59, CI = 0.43-0.81) and siblings (OR = 0.70, CI = 0.52-0.94) and had a higher rate of obesity than did controls (OR = 3.67, CI = 1.42-9.52). Parents of probands reported high rates of CVD (significantly higher than did parents of controls), including myocardial infarction and CVD-related hospitalization (ORs = 1.62-4.36, CIs = 1.03-15.40). Differences in CVD risk factors between probands and controls were independent of parental CVD. CONCLUSIONS:Major depression in childhood is associated with an unfavorable CVD risk profile in adolescence, and risks for pediatric depression and CVD may coincide in families. Effective prevention and treatment of childhood depression may be a means to reduce the incidence of adult CVD.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Rottenberg J,Yaroslavsky I,Carney RM,Freedland KE,George CJ,Baji I,Dochnal R,Gádoros J,Halas K,Kapornai K,Kiss E,Osváth V,Varga H,Vetró A,Kovacs M

doi

10.1097/PSY.0000000000000028

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

122-7

issue

eissn

0033-3174

issn

1534-7796

pii

PSY.0000000000000028

journal_volume

pub_type

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The association between major depressive disorder in childhood and risk factors for cardiovascular disease in adolescence.