Hypocapnia associated with cardiac stress scintigraphy in chest pain patients with panic disorder.

Abstract:

OBJECTIVE:Patients with recurrent chest pain but no evidence of coronary artery disease often meet diagnostic criteria for panic disorder (PD). However, it can be argued that the phenomenological diagnosis of PD may not be valid in these normal coronary chest pain (NCCP) patients. The purpose of this study is to additionally validate the diagnosis of PD in chest pain patients by comparing PCO2 levels before and during myocardial stress scintigraphy in those with and without PD. METHOD:End-tidal PCO2 was measured before and during myocardial stress scintigraphy in 22 patients being evaluated for chest pain. Psychiatric diagnoses were assessed by structured interview. RESULTS:Eleven of the 19 patients (58%) with negative scintigrams met DSM-III-R diagnostic criteria for current panic disorder. Prestress PCO2 levels were significantly lower in these patients. Eight of the nine NCCP patients with prestress PCO2 < 34 mm Hg had PD. CONCLUSIONS:The finding of stress-related hypocapnia associated with PD in NCCP patients provides additional support for the validity of the diagnosis of PD in this population. The potential value of PCO2 measurements in screening for PD in patients with chest pain merits additional study.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Maddock RJ,Carter CS,Tavano-Hall L,Amsterdam EA

doi

10.1097/00006842-199801000-00013

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

52-5

issue

1

eissn

0033-3174

issn

1534-7796

journal_volume

60

pub_type

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