The influence of concentration/meditation on autonomic nervous system activity and the innate immune response: a case study.

Abstract:

OBJECTIVE:In this case study, we describe the effects of a particular individual's concentration/meditation technique on autonomic nervous system activity and the innate immune response. The study participant holds several world records with regard to tolerating extreme cold and claims that he can influence his autonomic nervous system and thereby his innate immune response. METHODS:The individual's ex vivo cytokine response (stimulation of peripheral blood mononuclear cells with lipopolysaccharide [LPS]) was determined before and after an 80-minute full-body ice immersion during which the individual practiced his concentration/meditation technique. Furthermore, the individual's in vivo innate immune response was studied while practicing his concentration/mediation technique during human endotoxemia (intravenous administration of 2 ng/kg LPS). The results from the endotoxemia experiment were compared with a historical cohort of 112 individuals who participated in endotoxemia experiments in our institution. RESULTS:The ex vivo proinflammatory and anti-inflammatory cytokine response was greatly attenuated by concentration/meditation during ice immersion, accompanied by high levels of cortisol. In the endotoxemia experiment, concentration/meditation resulted in increased circulating concentrations of catecholamines, and plasma cortisol concentrations were higher than in any of the previously studied participants. The individual's in vivo cytokine response and clinical symptoms after LPS administration were remarkably low compared with previously studied participants. CONCLUSIONS:The concentration/meditation technique used by this particular individual seems to evoke a controlled stress response. This response is characterized by sympathetic nervous system activation and subsequent catecholamine/cortisol release, which seems to attenuate the innate immune response.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Kox M,Stoffels M,Smeekens SP,van Alfen N,Gomes M,Eijsvogels TM,Hopman MT,van der Hoeven JG,Netea MG,Pickkers P

doi

10.1097/PSY.0b013e3182583c6d

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

489-94

issue

5

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3182583c6d

journal_volume

74

pub_type

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