Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).


OBJECTIVE:Melissa officinalis (lemon balm) is contemporaneously used as a mild sedative and/or calming agent. Although recent research has demonstrated modulation of mood in keeping with these roles, no studies to date have directly investigated the effects of this herbal medication on laboratory-induced psychological stress. METHODS:In this double-blind, placebo-controlled, randomized, balanced crossover experiment, 18 healthy volunteers received two separate single doses of a standardized M. officinalis extract (300 mg, 600 mg) and a placebo, on separate days separated by a 7-day washout period. Modulation of mood was assessed during predose and 1-hour postdose completions of a 20-minute version of the Defined Intensity Stressor Simulation (DISS) battery. Cognitive performance on the four concurrent tasks of the battery was also assessed. RESULTS:The results showed that the 600-mg dose of Melissa ameliorated the negative mood effects of the DISS, with significantly increased self-ratings of calmness and reduced self-ratings of alertness. In addition, a significant increase in the speed of mathematical processing, with no reduction in accuracy, was observed after ingestion of the 300-mg dose. CONCLUSION:These results suggest that the potential for M. officinalis to mitigate the effects of stress deserves further investigation.


Psychosom Med


Psychosomatic medicine


Kennedy DO,Little W,Scholey AB




Has Abstract


2004-07-01 00:00:00














  • Predictability, attentional focus, sex role orientation, and menstrual-related stress.

    abstract::Two separate studies assessed the influence on menstrual distress and related inhibition of such variables as predictability of onset, dispositional susceptibility to cultural expectations, and the attentional focus provided by labels. Greater predictability of onset was associated with more positive feedlings about m...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Chernovetz ME,Jones WH,Hansson RO

    更新日期:1979-08-01 00:00:00

  • Diagnostic groups and depressed mood as predictors of 22-month mortality in medical inpatients.

    abstract:OBJECTIVE:While depression has been found to predict mortality in acute myocardial infarction, results from many other groups of medical patients are inconclusive. It is, therefore, unclear whether depression also predicts mortality in the typical mixed patient populations treated on medical hospital wards and whether ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Herrmann C,Brand-Driehorst S,Kaminsky B,Leibing E,Staats H,Rüger U

    更新日期:1998-09-01 00:00:00

  • Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity.

    abstract:OBJECTIVE:A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS:We measured morn...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Monteleone P,Tortorella A,Martiadis V,Serritella C,Fuschino A,Maj M

    更新日期:2004-09-01 00:00:00

  • Alexithymia as predictor of treatment outcome in patients with functional gastrointestinal disorders.

    abstract:OBJECTIVE:A previous study found a strong association between alexithymia and functional gastrointestinal disorders (FGID). The objective of this study was to investigate whether alexithymia might be a predictor of treatment outcome in patients with FGID. METHODS:A group of FGID outpatients classified by the 'Rome I' ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Porcelli P,Bagby RM,Taylor GJ,De Carne M,Leandro G,Todarello O

    更新日期:2003-09-01 00:00:00

  • Social stress influences tumor growth.

    abstract::Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated following social and physical stress exposure. Although social isolation following tumor cell transplantation enhanced tumor growth, it appeared that it was the abrupt change in social conditions, rather than the isolation per se which was responsi...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Sklar LS,Anisman H

    更新日期:1980-05-01 00:00:00

  • Social problem solving and noncardiac chest pain.

    abstract:OBJECTIVE:To investigate differences in social problem solving (SPS) between individuals with noncardiac chest pain (NCCP) and persons with chest pain who tested positive for underlying cardiac disease. METHODS:The major design involved a matched case-control methodology and compared a group of patients with NCCP (n =...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Nezu AM,Nezu CM,Jain D,Xanthopoulos MS,Cos TA,Friedman J,Lee M

    更新日期:2007-12-01 00:00:00

  • Intrusion, avoidance, and psychological distress among individuals with cancer.

    abstract:OBJECTIVE:The goal of the study was to examine the utility of Creamer's cognitive processing theory of trauma in a sample of individuals undergoing treatment for cancer. This theory proposes that avoidance is a maladaptive strategy of dealing with intrusive thoughts about a traumatic experience and suggests that avoida...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Manne S,Glassman M,Du Hamel K

    更新日期:2001-07-01 00:00:00

  • Phobic anxiety and increased risk of mortality in coronary heart disease.

    abstract:OBJECTIVES:To evaluate whether phobic anxiety is associated with increased risk of cardiac mortality in individuals with established coronary heart disease (CHD) and to examine the role of reduced heart rate variability (HRV) in mediating this risk. Previous findings suggest that phobic anxiety may pose increased risk ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Watkins LL,Blumenthal JA,Babyak MA,Davidson JR,McCants CB Jr,O'Connor C,Sketch MH Jr

    更新日期:2010-09-01 00:00:00

  • Life events and acute cardiovascular reactions to mental stress: a cohort study.

    abstract:OBJECTIVE:This study addressed the issue of whether frequent exposure to life events is associated with aggravation or blunting of cardiovascular reactions to acute mental stress. METHODS:In a substantial cohort of 585 healthy young adults, systolic and diastolic blood pressure and pulse rate were recorded at rest and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Phillips AC,Carroll D,Ring C,Sweeting H,West P

    更新日期:2005-05-01 00:00:00

  • Childhood Bullying Victimization and Overweight in Young Adulthood: A Cohort Study.

    abstract:OBJECTIVE:To test whether bullied children have an elevated risk of being overweight in young adulthood and whether this association is: (1) consistent with a dose-response relationship, namely, its strength increases with the chronicity of victimization; (2) consistent across different measures of overweight; (3) spec...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Baldwin JR,Arseneault L,Odgers C,Belsky DW,Matthews T,Ambler A,Caspi A,Moffitt TE,Danese A

    更新日期:2016-11-01 00:00:00

  • Sexual orientation and disclosure in relation to psychiatric symptoms, diurnal cortisol, and allostatic load.

    abstract:OBJECTIVES:Lesbian, gay, and bisexual (LGB) individuals-particularly those who have not disclosed their sexual orientation-are believed to experience increased chronic stress in comparison with heterosexuals. This interdisciplinary study assessed whether psychiatric symptoms (self-rated anxiety, depression, and burnout...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Juster RP,Smith NG,Ouellet É,Sindi S,Lupien SJ

    更新日期:2013-02-01 00:00:00

  • Increased risks of acute organ dysfunction and mortality in intensive care unit patients with schizophrenia: a nationwide population-based study.

    abstract:OBJECTIVE:To investigate the risks of acute organ dysfunction and death in intensive care unit (ICU) patients with schizophrenia. METHODS:Using a retrospective matched cohort design, we compared 203 schizophrenic patients to 2036 demographically matched (1:10) nonschizophrenic patients with first-time ICU admission be...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Shen HN,Lu CL,Yang HH

    更新日期:2011-09-01 00:00:00

  • Aerobic fitness level and reactivity to psychosocial stress: physiological, biochemical, and subjective measures.

    abstract::Aerobic fitness is associated with numerous physiological adaptations which permit physical stress to be coped with more efficiently. The present experiment examined whether aerobic fitness influences emotional response. Heart rate, biochemical measures (catecholamines, cortisol, prolactin, lactic acid), and self-repo...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Sinyor D,Schwartz SG,Peronnet F,Brisson G,Seraganian P

    更新日期:1983-06-01 00:00:00

  • Depressed mood, positive affect, and heart rate variability in patients with suspected coronary artery disease.

    abstract:OBJECTIVE:To test associations between heart rate variability (HRV), depressed mood, and positive affect in patients with suspected coronary artery disease (CAD). Depression is associated with impaired HRV post acute cardiac events, but evidence in patients with stable coronary artery disease (CAD) is inconsistent. ME...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究


    authors: Bhattacharyya MR,Whitehead DL,Rakhit R,Steptoe A

    更新日期:2008-11-01 00:00:00

  • Psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans.

    abstract::Recent research with animals has indicated a central nervous system effect on the immune system. This report describes findings of a possible psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans. Seven tuberculin positive subjects evidenced a decreased response to tuberculin...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Smith GR Jr,McDaniel SM

    更新日期:1983-03-01 00:00:00

  • Characteristics of Autonomic Activity and Reactivity During Rest and Emotional Processing and Their Clinical Correlations in Somatic Symptom Disorder.

    abstract:OBJECTIVE:Altered autonomic nervous system activity is considered to be involved in the pathophysiology of somatic symptom disorder (SSD). This study aimed to investigate whether patients with SSD have disturbed autonomic activity during rest and reactivity to emotional processing and whether altered autonomic nervous ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Lee D,Kim SJ,Cheon J,Hwang EH,Jung YC,Kang JI

    更新日期:2018-10-01 00:00:00

  • Longitudinal follow-up of amenorrhea in eating disorders.

    abstract::The authors recruited 229 treatment-seeking anorexic and bulimic women for a prospective, longitudinal study. Telephone interviews were arranged every 3 months for at least 1 year for 225 patients. At intake, 132 subjects were menstruating, 34 subjects were taking oral contraceptives, 5 subjects had an organic cause f...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Copeland PM,Sacks NR,Herzog DB

    更新日期:1995-03-01 00:00:00

  • Blood pressure reactions to acute mental stress and future blood pressure status: data from the 12-year follow-up of the West of Scotland Study.

    abstract:OBJECTIVE:To test the reactivity hypothesis using blood pressure data collected 12 years after baseline. This study examined whether blood pressure reactions to acute mental stress predicted future blood pressure resting levels, as well as the temporal drift in resting blood pressure, and whether the prediction was aff...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Carroll D,Phillips AC,Der G,Hunt K,Benzeval M

    更新日期:2011-11-01 00:00:00

  • A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds.

    abstract:OBJECTIVE:To examine the association between the experience of daily interpersonal stress and levels of C-reactive protein (CRP), an inflammatory marker that is a key indicator of cardiovascular risk, during the teenage years. METHODS:A total of 69 adolescents (Mage= 17.78 years) completed daily diary checklists each ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Fuligni AJ,Telzer EH,Bower J,Cole SW,Kiang L,Irwin MR

    更新日期:2009-04-01 00:00:00

  • Job strain, overweight and diabetes: a 13-year prospective study among 12,896 men and women in Ontario.

    abstract:OBJECTIVE:The American Diabetes Association recently called for research on social and environmental determinants of diabetes to intensify primary prevention. Recent epidemiological evidence suggests that frequent and modifiable psychosocial stressors at work might contribute to the development of diabetes, but more pr...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Gilbert-Ouimet M,Glazier RH,Brisson C,Mustard C,Smith PM

    更新日期:2020-12-15 00:00:00

  • The Effect of Light-Intensity Cycling on Mood and Working Memory in Response to a Randomized, Placebo-Controlled Design.

    abstract:OBJECTIVE:Prior attempts to measure psychological responses to exercise are potentially limited by a failure to account for participants' expectations, the absence of a valid exercise placebo, and demand characteristics. The purpose of this study was to explore the main and interactive effects of a manipulation designe...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Lindheimer JB,OʼConnor PJ,McCully KK,Dishman RK

    更新日期:2017-02-01 00:00:00

  • Neuroticism and cynicism and risk of death in middle-aged men: the Western Electric Study.

    abstract::MMPI measures of neuroticism (N) and of cynicism (C) were obtained at the initial examination of 1871 employed, middle-aged men in Chicago. Neither N nor C was significantly associated cross-sectionally with systolic blood pressure or serum cholesterol, but both were positively associated with cigarette smoking and al...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Almada SJ,Zonderman AB,Shekelle RB,Dyer AR,Daviglus ML,Costa PT Jr,Stamler J

    更新日期:1991-03-01 00:00:00

  • Pain-related emotions in early stages of recovery in whiplash-associated disorders: their presence, intensity, and association with pain recovery.

    abstract:OBJECTIVE:Psychological factors such as depression affect recovery after whiplash-associated disorders. This study examined the prevalence of pain-related emotions, such as frustration, anger, and anxiety, and their predictive value for postcrash pain recovery during a 1-year follow-up. METHODS:A population-based pros...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Carroll LJ,Liu Y,Holm LW,Cassidy JD,Côté P

    更新日期:2011-10-01 00:00:00

  • Stress vulnerability during adolescence: comparison of chronic stressors in adolescent and adult rats.

    abstract:OBJECTIVE:This study investigated the physiological and somatic changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in adolescent and adult rats, with a focus on cardiovascular function. The long-term effects of stress exposure during adolescenc...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Duarte JO,Cruz FC,Leão RM,Planeta CS,Crestani CC

    更新日期:2015-02-01 00:00:00

  • Cynicism and paranoid alienation in the Cook and Medley HO Scale.

    abstract::Factor analysis of responses from 1002 men and women were used to define two subscales of the Cook and Medley Hostility Scale. Both the Cynicism and the Paranoid Alienation subscale described attitudes of mistrust and alienation, and both were correlated with MMPI factors measuring aspects of psychopathology. It was s...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Costa PT Jr,Zonderman AB,McCrae RR,Williams RB Jr

    更新日期:1986-03-01 00:00:00

  • Neuroticism and cardiovascular disease mortality: socioeconomic status modifies the risk in women (UK Health and Lifestyle Survey).

    abstract:OBJECTIVE:The association between personality traits and mortality might differ as a function of socioeconomic status (SES). Our aim was to evaluate the all-cause, cardiovascular disease (CVD), and cancer mortality risk associated with neuroticism or extraversion and their interactions with SES in a representative samp...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Hagger-Johnson G,Roberts B,Boniface D,Sabia S,Batty GD,Elbaz A,Singh-Manoux A,Deary IJ

    更新日期:2012-07-01 00:00:00

  • Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women-The Women's Health Initiative.

    abstract:OBJECTIVE:Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). METHODS:We conducted a longitudinal analysis using data f...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Salmoirago-Blotcher E,Hovey KM,Andrews CA,Allison M,Brunner RL,Denburg NL,Eaton C,Garcia L,Sealy-Jefferson SM,Zaslavsky O,Kang J,López L,Post SG,Tindle H,Wassertheil-Smoller S

    更新日期:2019-04-01 00:00:00

  • Psychological correlates of progression of atherosclerosis in men.

    abstract::Patients who underwent repetitive repetitive coronary angiograms at an average interval of 17 months completed the Jenkins Activity Survey (n = 66) and were given the Rosenman diagnostic interview to measure Type A behavior (n = 45). Significant progression of coronary artery disease was judged to be an increase in oc...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Krantz DS,Sanmarco MI,Selvester RH,Matthews KA

    更新日期:1979-10-01 00:00:00

  • Relationship between work stress and body mass index among 45,810 female and male employees.

    abstract:OBJECTIVE:The proportion of overweight and obese people has grown rapidly, and obesity has now been widely recognized as an important public health problem. At the same time, stress has increased in working life. The 2 problems could be connected if work stress promotes unhealthy eating habits and sedentary behavior an...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Kouvonen A,Kivimäki M,Cox SJ,Cox T,Vahtera J

    更新日期:2005-07-01 00:00:00

  • Patterning of cognitive and somatic processes in the self-regulation of anxiety: effects of meditation versus exercise.

    abstract::Davidson and Schwartz (1) have proposed a psychobiological analysis of anxiety that emphasizes the patterning of multiple processes in the generation and self-regulation of this state. The present article specifically reviews recent research on cognitive and somatic components of anxiety. A dual component scale which ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Schwartz GE,Davidson RJ,Goleman DJ

    更新日期:1978-06-01 00:00:00