Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study.


OBJECTIVE:The Enhancing Recovery in Coronary Heart Disease study was a multicenter clinical trial in which patients with depression and/or low perceived social support after an acute myocardial infarction were randomly assigned to an intervention consisting of cognitive behavior therapy and, in some cases, sertraline, or to usual care. There was no difference in survival between the groups. A possible reason why the intervention failed to affect survival is that too many patients with mild, transient depression were enrolled. Another is that some patients died too soon to complete the intervention. This analysis evaluates whether there was a difference in late (ie, > or =6 months after the myocardial infarction) mortality among initially depressed patients who had a Beck Depression Inventory score > or =10 and a past history of major depression, and who completed the 6-month post-treatment assessment. It also examines the relationship between change in depression and late mortality. METHODS:Out of the 1,165 (47%) of the Enhancing Recovery in Coronary Heart Disease study participants who met our criteria, 57 died in the first 6 months, and 858 (409 usual care, 449 intervention) completed the 6-month assessment. Cox regression was used to analyze survival. RESULTS:The intervention did not affect late mortality. However, intervention patients whose depression did not improve were at higher risk for late mortality than were patients who responded to treatment. CONCLUSIONS:Patients whose depression is refractory to cognitive behavior therapy and sertraline, two standard treatments for depression, are at high risk for late mortality after myocardial infarction.


Psychosom Med


Psychosomatic medicine


Carney RM,Blumenthal JA,Freedland KE,Youngblood M,Veith RC,Burg MM,Cornell C,Saab PG,Kaufmann PG,Czajkowski SM,Jaffe AS,ENRICHD Investigators.




Has Abstract


2004-07-01 00:00:00














  • A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds.

    abstract:OBJECTIVE:To examine the association between the experience of daily interpersonal stress and levels of C-reactive protein (CRP), an inflammatory marker that is a key indicator of cardiovascular risk, during the teenage years. METHODS:A total of 69 adolescents (Mage= 17.78 years) completed daily diary checklists each ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Fuligni AJ,Telzer EH,Bower J,Cole SW,Kiang L,Irwin MR

    更新日期:2009-04-01 00:00:00

  • Testosterone, aggression, physical, and personality dimensions in normal adolescent males.

    abstract::Fifty-eight normal adolescent Swedish boys, aged 16, provided two sets of blood samples for plasma testosterone assays as well as data on a number of personality inventories and rating scales assessing aggression, inpulsiveness, lack of frustration tolerance, extraversion, and anxiety. Physical variables such as puber...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Olweus D,Mattsson A,Schalling D,Löw H

    更新日期:1980-03-01 00:00:00

  • Self-awareness, alcohol consumption, and reduced cardiovascular reactivity.

    abstract::Seventy-two healthy males were divided into Type A and Type B groups using the Jenkins Activity Survey. Subjects were subdivided further into high and low self-awareness categories on the private self-consciousness factor of the Self-Consciousness Scale. After random assignment to consume alcohol (0.85 g/kg) or a plac...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Niaura R,Wilson GT,Westrick E

    更新日期:1988-07-01 00:00:00

  • The Association Between Temperament and Microbiota in Healthy Individuals: A Pilot Study.

    abstract:OBJECTIVE:The purpose of this study was to examine whether enterotypes in the gut microbiome could be determined by clustering validity indexes and whether these enterotypes were associated with individual differences in temperament traits. METHODS:Sixty healthy Korean participants (21 men; 27.5 [8.1] years, 39 women;...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Kim H,Park YJ

    更新日期:2017-10-01 00:00:00

  • Association of baseline anxiety with depression persistence at 6 months in patients with acute cardiac illness.

    abstract:OBJECTIVE:To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization. METHODS:Data were analyzed from 137 depressed patients hospitalized on inpatient cardiac units for acute coronary syndrome, decompensated heart failure, or arrhy...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验


    authors: Celano CM,Mastromauro CA,Lenihan EC,Januzzi JL,Rollman BL,Huffman JC

    更新日期:2012-01-01 00:00:00

  • Pervasive Discrimination and Allostatic Load in African American and White Adults.

    abstract:OBJECTIVE:This study aimed to examine associations among race, the accumulation of multiple forms of discriminatory experiences (i.e., "pervasive discrimination"), and allostatic load (AL) in African Americans and whites in midlife. METHODS:Using data collected in 2004 to 2006 from 226 African American and 978 white a...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Van Dyke ME,Baumhofer NK,Slopen N,Mujahid MS,Clark CR,Williams DR,Lewis TT

    更新日期:2020-04-01 00:00:00

  • Genetic Predictors of Depressive Symptoms in the Look AHEAD Trial.

    abstract:OBJECTIVES:Numerous studies have found elevated depressive symptoms among individuals with Type 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict depressive symptoms among overweight/obese individuals with Type 2 diabetes or change in ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: McCaffery JM,Papandonatos GD,Faulconbridge LF,Erar B,Peter I,Wagenknecht LE,Pajewski NM,Anderson A,Wadden TA,Wing RR,Look AHEAD Research Group.

    更新日期:2015-11-01 00:00:00

  • Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder.

    abstract:OBJECTIVE:The thermal grill illusion (TGI) in which interlacing cold and warm bars create the illusion of a painful sensation has been suggested as an experimental model for central pain states and pain processing. The aim of this study was to use this technique to gain further insights into the altered pain perception...

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    pub_type: 杂志文章


    authors: Boettger MK,Grossmann D,Bär KJ

    更新日期:2013-04-01 00:00:00

  • Race and Resting-State Heart Rate Variability in Brazilian Civil Servants and the Mediating Effects of Discrimination: An ELSA-Brasil Cohort Study.

    abstract:OBJECTIVES:African Americans are characterized by higher heart rate variability (HRV), a finding ostensibly associated with beneficial health outcomes. However, these findings are at odds with other evidence that blacks have worse cardiovascular outcomes. Here, we examine associations in a large cohort from the ELSA-Br...

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    pub_type: 杂志文章


    authors: Kemp AH,Koenig J,Thayer JF,Bittencourt MS,Pereira AC,Santos IS,Dantas EM,Mill JG,Chor D,Ribeiro AL,Benseñor IM,Lotufo PA

    更新日期:2016-10-01 00:00:00

  • Metabolic risk factors and posttraumatic stress disorder: the role of sleep in young, healthy adults.

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Talbot LS,Rao MN,Cohen BE,Richards A,Inslicht SS,OʼDonovan A,Maguen S,Metzler TJ,Neylan TC

    更新日期:2015-05-01 00:00:00

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    pub_type: 杂志文章


    authors: López-Solà M,Koban L,Wager TD

    更新日期:2018-11-01 00:00:00

  • Serum cholesterol and cognitive performance in the Framingham Heart Study.

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Elias PK,Elias MF,D'Agostino RB,Sullivan LM,Wolf PA

    更新日期:2005-01-01 00:00:00

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    abstract:OBJECTIVES:Exposure to child abuse (CA) is associated with an increased risk of developing asthma and allergies; it is unknown if that risk is present across generations. This study investigated if 2-year-old children born to mothers with a history of CA were at an increased risk of receiving a diagnosis of asthma or a...

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    pub_type: 杂志文章


    authors: Tomfohr-Madsen LM,Bayrampour H,Tough S

    更新日期:2016-11-01 00:00:00

  • Psychological stress as a determinant of protein levels and salivary-induced aggregation of Streptococcus gordonii in human whole saliva.

    abstract::Several pathologies of the oral cavity have been associated with stress, so we investigated salivary-induced aggregation during psychological stress. In addition, salivary total protein, alpha-amylase, and secretory immunoglobulin A (s-IgA) were assessed. In this longitudinal study, 28 dental students provided unstimu...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Bosch JA,Brand HS,Ligtenberg TJ,Bermond B,Hoogstraten J,Nieuw Amerongen AV

    更新日期:1996-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Porcelli P,Bagby RM,Taylor GJ,De Carne M,Leandro G,Todarello O

    更新日期:2003-09-01 00:00:00

  • The relationship between cardiovascular reactivity in the laboratory and heart rate response in real life: active coping and beta blockade.

    abstract::Earlier studies suggest that cardiovascular responses in the laboratory and in the field are likely to be related when the laboratory tasks involve active coping, when the field measure is taken continuously, and when there is allowance for the effects of autocorrelation and physical activity on the ambulant cardiovas...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Johnston DW,Schmidt TF,Albus C,Vagt S,McSorley K,Klingmann I,Bethge H

    更新日期:1994-07-01 00:00:00

  • Conditioned pharmacotherapeutic effects: a preliminary study.

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ader R,Mercurio MG,Walton J,James D,Davis M,Ojha V,Kimball AB,Fiorentino D

    更新日期:2010-02-01 00:00:00

  • Salivary MUC5B-mediated adherence (ex vivo) of Helicobacter pylori during acute stress.

    abstract:OBJECTIVE:Biochemical host defenses at mucosal sites, such as the oral cavity, play a key role in the regulation of microbial ecology and the prevention of infectious disease. These biochemical factors have distinct features, some of which benefit the host and some that benefit bacteria. We investigated the effects of ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Bosch JA,de Geus EJ,Ligtenberg TJ,Nazmi K,Veerman EC,Hoogstraten J,Amerongen AV

    更新日期:2000-01-01 00:00:00

  • Hypertension affects neurobehavioral functioning.

    abstract::This study compared the neurobehavioral performance of hypertensive and normotensive men and women using neuropsychological, information-processing, and psychometric assessments. One hundred subjects, including 68 hypertensive and 32 normotensive individuals, completed a test battery that yielded scores on measures of...

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    pub_type: 杂志文章


    authors: Blumenthal JA,Madden DJ,Pierce TW,Siegel WC,Appelbaum M

    更新日期:1993-01-01 00:00:00

  • Sexual orientation and disclosure in relation to psychiatric symptoms, diurnal cortisol, and allostatic load.

    abstract:OBJECTIVES:Lesbian, gay, and bisexual (LGB) individuals-particularly those who have not disclosed their sexual orientation-are believed to experience increased chronic stress in comparison with heterosexuals. This interdisciplinary study assessed whether psychiatric symptoms (self-rated anxiety, depression, and burnout...

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    pub_type: 杂志文章


    authors: Juster RP,Smith NG,Ouellet É,Sindi S,Lupien SJ

    更新日期:2013-02-01 00:00:00

  • Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.

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    pub_type: 杂志文章


    authors: Blumenthal JA,Smith PJ,Mabe S,Hinderliter A,Welsh-Bohmer K,Browndyke JN,Lin PH,Kraus W,Doraiswamy PM,Burke J,Sherwood A

    更新日期:2017-07-01 00:00:00

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Houpt JL,Gould BS,Norris FH Jr

    更新日期:1977-09-01 00:00:00

  • Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging.

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验


    authors: Xian H,Scherrer JF,Franz CE,McCaffery J,Stein PK,Lyons MJ,Jacobsen K,Eisen SA,Kremen WS

    更新日期:2010-05-01 00:00:00

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    abstract::Serial sampling of peripheral blood from six healthy adult male volunteers was performed during daytime waking and nighttime sleeping. In addition, sleep physiology was assessed in all subjects (Ss) and sleep stages scored blind by standard criteria. Samples of plasma were analyzed for cortisol (Co) levels, functional...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Moldofsky H,Lue FA,Eisen J,Keystone E,Gorczynski RM

    更新日期:1986-05-01 00:00:00

  • Occupational differences in job strain and physiological stress: female nurses and school teachers in Hawaii.

    abstract:OBJECTIVES:The two objectives are to test the hypothesis that women in a profession with low decision latitude will have greater catecholamine excretion and higher blood pressure than women in a profession with greater decision latitude, and to assess the influence of ethnicity on the occupational comparison. METHODS:...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Brown DE,James GD,Mills PS

    更新日期:2006-07-01 00:00:00

  • Presidential Address-1976. Social support as a moderator of life stress.

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Cobb S

    更新日期:1976-09-01 00:00:00

  • Cardiovascular Risk Factors as Differential Predictors of Incident Atypical and Typical Major Depressive Disorder in US Adults.

    abstract:OBJECTIVE:Although the association between major depressive disorder (MDD) and future cardiovascular disease (CVD) is established, less is known about the relationship between CVD risk factors and future depression, and no studies have examined MDD subtypes. Our objective was to determine whether hypertension, tobacco ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Patel JS,Berntson J,Polanka BM,Stewart JC

    更新日期:2018-07-01 00:00:00

  • Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening.

    abstract:OBJECTIVE:There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the cortisol response during the first hour in the morning with strict reference to the time of awakening was established as a reliable marker of individual adrenocortical activ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Pruessner M,Hellhammer DH,Pruessner JC,Lupien SJ

    更新日期:2003-01-01 00:00:00

  • Do low cholesterol levels slow mental processing?

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    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Benton D

    更新日期:1995-01-01 00:00:00

  • Denial and medical outcome in unstable angina.

    abstract::Denial may be adaptive during hospitalization for acute coronary disease. We studied the impact of denial in 48 patients referred to a tertiary care center for treatment of unstable angina. Using the Hackett-Cassem Denial Scale, we divided the group into 25 high deniers and 23 low deniers. The two groups were comparab...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Levenson JL,Mishra A,Hamer RM,Hastillo A

    更新日期:1989-01-01 00:00:00