Abstract:
OBJECTIVE:To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status. METHODS:Data from 38 HIV-positive and 29 HIV-negative children born to seropositive women were obtained. Measures included family adversity questionnaires, autonomic nervous system (ANS) reactivity, and enumerative and functional changes in peripheral blood immune parameters. RESULTS:In comparison with children who were HIV-negative, children who were HIV-positive at baseline had fewer CD4(+) T lymphocytes (mean [M] = 916 versus 1206 cells/mm(3) × 10(3); F = 7.8, p = .007), more CD8(+) cells (M = 1046 versus 720 cells/mm(3) × 10(3); F = 7.98, p = .006), and diminished natural killer cell cytotoxicity (M = -0.29 versus 0.41; F = 8.87, p = .004). School entry was associated with changes in immune parameters, but HIV status was not associated with the magnitude of changes. Changes in immune parameters after school entry were associated with family stress and preschool entry ANS reactivity. Highly ANS reactive children had either the greatest increase in CD8(+) cells after school entry or the greatest decrease, depending on reported levels of family adversity (B = 215.35; t = 3.74, p < .001). Changes in functional immune assays were significantly associated with the interactions between HIV status and ANS reactivity. CONCLUSIONS:These results suggest that autonomic reactivity is associated with increased immunological sensitivity to adverse or challenging social contexts among children affected by HIV.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Thomas MR,Wara D,Saxton K,Truskier M,Chesney MA,Boyce WTdoi
10.1097/PSY.0b013e31829807fbsubject
Has Abstractpub_date
2013-07-01 00:00:00pages
557-65issue
6eissn
0033-3174issn
1534-7796pii
PSY.0b013e31829807fbjournal_volume
75pub_type
杂志文章abstract:OBJECTIVES:To review the relevance of cultural models in the generation and amplification of somatic symptoms and syndromes. METHODS:Based on a selective review of literature, we examine evidence that cultural and personal explanatory models can contribute to the pathogenesis, symptomatology, and chronicity of medical...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
abstract::Factor analysis of responses from 1002 men and women were used to define two subscales of the Cook and Medley Hostility Scale. Both the Cynicism and the Paranoid Alienation subscale described attitudes of mistrust and alienation, and both were correlated with MMPI factors measuring aspects of psychopathology. It was s...
journal_title:Psychosomatic medicine
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journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-07-01 00:00:00
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更新日期:2007-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e31815c1b5d
更新日期:2008-01-01 00:00:00
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pub_type: 评论,杂志文章
doi:10.1097/PSY.0000000000000682
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00006842-199109000-00005
更新日期:1991-09-01 00:00:00
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doi:10.1097/PSY.0000000000000583
更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:1996-09-01 00:00:00
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doi:10.1097/00006842-197709000-00003
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pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00006842-198507000-00001
更新日期:1985-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00006842-198805000-00006
更新日期:1988-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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更新日期:1999-11-01 00:00:00