Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence: the Ryukyus Child Health Study.

Abstract:

OBJECTIVE:To examine the association between dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in a group of adolescents. METHODS:This cross-sectional study, conducted in all public junior high schools in Naha City and Nago City, Okinawa, Japan, included 3,067 boys and 3,450 girls aged 12 years to 15 years (52.3% of eligible sample). Dietary intake was assessed using a validated, self-administered diet history questionnaire. Depressive symptoms were defined as present when participants had a Center for Epidemiologic Studies Depression Scale score of ≥16. RESULTS:The prevalence of depressive symptoms was 22.5% for boys and 31.2% for girls. Folate intake was inversely associated with depressive symptoms in both boys (adjusted odds ratio (OR) [95% confidence interval (CI)] in the highest (compared with the lowest) quintile, 0.60 [0.45, 0.79]; p for trend = .002) and girls (OR [95% CI], 0.61 [0.48, 0.77]; p for trend = <.001). Vitamin B-6 intake was inversely associated with depressive symptoms in both boys (OR [95% CI], 0.73 [0.54, 0.98]; p for trend = .02) and girls (OR [95% CI], 0.72 [0.56, 0.92]; p for trend = .002). Riboflavin intake was inversely associated with depressive symptoms in girls (OR [95% CI], 0.85 [0.67, 1.08]; p for trend = .03), but not in boys. No clear association was seen between vitamin B-12 intake and depressive symptoms in either sex. CONCLUSIONS:This study suggests that higher intake of dietary B vitamins, particularly folate and vitamin B-6, is independently associated with a lower prevalence of depressive symptoms in early adolescence.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Murakami K,Miyake Y,Sasaki S,Tanaka K,Arakawa M

doi

10.1097/PSY.0b013e3181f02f15

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

763-8

issue

8

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3181f02f15

journal_volume

72

pub_type

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