Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly.

Abstract:

OBJECTIVE:To assess the association between frailty and incident Alzheimer's disease (AD) and cognitive decline. Frailty is common in older persons and associated with adverse health outcomes. METHODS:Study subjects included 823 older persons without dementia who participated in the Rush Memory and Aging Project, a longitudinal study of aging, and underwent annual assessments of frailty, cognition, and diagnostic evaluation for AD. RESULTS:During a 3-year follow-up, 89 of 823 participants developed AD. In a proportional hazards model, both baseline level of frailty and annual rate of change in frailty were associated with an increased risk of incident AD. Each additional one tenth of a unit increase on the frailty scale at baseline was associated with >9% increased risk of AD (hazard ratio: 2.44; 95% confidence interval (CI): 1.49, 3.37); each one tenth of a unit increase in annual rate of change in frailty was associated with a 12% increased risk of AD (hazard ratio: 3.30; 95% CI: 1.52, 7.13). These results were unchanged in analyses controlling for vascular risk factors and vascular diseases. Results were similar with a categorical measure of frailty instead of a continuous measure. Further, linear mixed-effects models showed that the level of and rate of change in frailty were also associated with the rate of cognitive decline. CONCLUSION:Increasing frailty is associated with incident AD and the rate of cognitive decline in older persons. These findings suggest that frailty and AD may share similar etiologies.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Buchman AS,Boyle PA,Wilson RS,Tang Y,Bennett DA

doi

10.1097/psy.0b013e318068de1d

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

483-9

issue

5

eissn

0033-3174

issn

1534-7796

pii

psy.0b013e318068de1d

journal_volume

69

pub_type

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