Abstract:
OBJECTIVE:Fatigue is a common problem among cancer patients and survivors, yet the mechanisms underlying the occurrence and persistence of this symptom are not known. Activation of the immune system may evoke feelings of fatigue, which are mediated by proinflammatory cytokines. We examined whether fatigued breast cancer survivors would show elevations in proinflammatory cytokines and markers of cytokine activity compared with nonfatigued survivors. Differences in lymphocyte subsets, cortisol, and behavioral symptoms associated with proinflammatory cytokines were also assessed. METHODS:Forty breast cancer survivors (20 fatigued, 20 nonfatigued) provided blood samples at visits scheduled to control for diurnal variability. Cytokines, soluble markers of cytokine activity, and cortisol were measured by immunoassay and lymphocyte subsets by flow cytometry. Participants also completed questionnaires measuring demographic, medical, and behavioral variables. RESULTS:Fatigued breast cancer survivors had significantly higher serum levels of several markers associated with proinflammatory cytokine activity than nonfatigued survivors, including interleukin-1 receptor antagonist (IL-1ra), soluble tumor necrosis factor receptor type II (sTNF-RII), and neopterin. They were also more likely to report behavioral problems that co-occur with fatigue in the context of immune activation. Fatigued survivors had significantly lower serum levels of cortisol than the nonfatigued group as well as differences in two lymphocyte populations. CONCLUSIONS:Fatigued breast cancer survivors showed elevations in serum markers associated with proinflammatory cytokine activity an average of 5 years after diagnosis. Results suggest mechanisms through which enduring immune activation may occur, including alterations in cortisol and in lymphocyte subsets.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Bower JE,Ganz PA,Aziz N,Fahey JLdoi
10.1097/00006842-200207000-00010subject
Has Abstractpub_date
2002-07-01 00:00:00pages
604-11issue
4eissn
0033-3174issn
1534-7796journal_volume
64pub_type
杂志文章abstract:OBJECTIVE:To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181990fff
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Several determinants of age-related hearing impairment have been identified, but little is known about the predictive value of psychological factors. The present study examined whether five-factor model personality traits are prospectively associated with hearing acuity in middle-aged and older adults. METHO...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000734
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:Rumination has been linked to self-reported sleep quality. However, whether rumination is related to an objective sleep parameter has not been tested. This study examined whether rumination predicts sleep onset latency (SOL) on the night after an acute psychosocial stressor. We hypothesized that those who ru...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181ae58e8
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:This study evaluated the ability of mental stress testing to discriminate between women with and without CHD, and among women with different disease manifestations, taking into account history of hypertension and beta-blocker use. METHODS:Analyses were based on data from a community-based case-control study ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200111000-00010
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:A model for the development of anxiety disorders (panic disorder with or without agoraphobia) is needed. Patients with an implantable cardioverter/defibrillator (ICD) are exposed to repeated electric shocks. If the theory of anxiety development by aversive classic conditioning processes is valid, these repeat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200103000-00006
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:African Americans are characterized by higher heart rate variability (HRV), a finding ostensibly associated with beneficial health outcomes. However, these findings are at odds with other evidence that blacks have worse cardiovascular outcomes. Here, we examine associations in a large cohort from the ELSA-Br...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000359
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether worries about work are linked to people's own cortisol levels and their spouses' cortisol levels in everyday life and whether marital factors may moderate these links. Although research has shown that satisfying marriages can buffer the physiological effects of everyday stress, the spec...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181f60fcc
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:Stress or emotional traumas are considered risk factors for unexplained fatiguing illnesses. From July to December 2001, the Centers for Disease Control and Prevention conducted a multigeographical pilot study to test the feasibility of a survey to estimate the prevalence of fatiguing illnesses in the United ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000138116.12495.a2
更新日期:2004-09-01 00:00:00
abstract::Twenty-two studies on the effects of psychological treatment on cancer patients are reviewed. Only studies that compared one or more experimental conditions with at least one control group have been considered. The studies were evaluated with respect to a) research methods, b) psychological interventions, and c) resul...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/00006842-199207000-00011
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between hostility and biological risk factors for coronary heart disease (CHD) in a population of white European and South Asian men and women living in the United Kingdom. METHODS:This cross-sectional study involved a community-based sample of 1,757 healthy white and South Asian ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181fd944c
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The American Diabetes Association recently called for research on social and environmental determinants of diabetes to intensify primary prevention. Recent epidemiological evidence suggests that frequent and modifiable psychosocial stressors at work might contribute to the development of diabetes, but more pr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000898
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:Prior attempts to measure psychological responses to exercise are potentially limited by a failure to account for participants' expectations, the absence of a valid exercise placebo, and demand characteristics. The purpose of this study was to explore the main and interactive effects of a manipulation designe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000381
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:Despite its simplicity, single-item measures of self-rated health have been associated with mortality independent of objective health conditions. However, little is known about the mechanisms potentially responsible for such associations. This study tested the association between self-rated heath and inflamma...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000683
更新日期:2019-05-01 00:00:00
abstract::Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated following social and physical stress exposure. Although social isolation following tumor cell transplantation enhanced tumor growth, it appeared that it was the abrupt change in social conditions, rather than the isolation per se which was responsi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198005000-00005
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship among Type D personality, self-efficacy, and medication adherence in patients with coronary heart disease. METHODS:The study design was prospective and observational. Type D personality, self-efficacy for illness management behaviors, and medication adherence were measured 3 weeks ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31823a5b2f
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association of a range of temporally prior physical conditions with the subsequent first onset of suicidal ideation, plans, and attempts in large, general population, cross-national sample. The associations between physical conditions and suicidal behavior remain unclear due to sparse data ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181e3333d
更新日期:2010-09-01 00:00:00
abstract::Denial may be adaptive during hospitalization for acute coronary disease. We studied the impact of denial in 48 patients referred to a tertiary care center for treatment of unstable angina. Using the Hackett-Cassem Denial Scale, we divided the group into 25 high deniers and 23 low deniers. The two groups were comparab...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198901000-00003
更新日期:1989-01-01 00:00:00
abstract::The authors recruited 229 treatment-seeking anorexic and bulimic women for a prospective, longitudinal study. Telephone interviews were arranged every 3 months for at least 1 year for 225 patients. At intake, 132 subjects were menstruating, 34 subjects were taking oral contraceptives, 5 subjects had an organic cause f...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199503000-00004
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:To investigate the risks of acute organ dysfunction and death in intensive care unit (ICU) patients with schizophrenia. METHODS:Using a retrospective matched cohort design, we compared 203 schizophrenic patients to 2036 demographically matched (1:10) nonschizophrenic patients with first-time ICU admission be...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182280016
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:The effect of stress exposures and mental health sequelae on health-related outcomes is understudied among older women veterans. We examined a) the impact of wartime stress exposures on later-life functioning and disability in Vietnam-era women veterans and b) the extent to which mental health conditions know...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000762
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here, we test a novel meaning-based intervention. Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a pos...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000609
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:The objectives of the study described here were to 1) examine the coping style of patients with functional dyspepsia (FD) and 2) adopt a new interview questionnaire to examine the extent of discriminativeness in the use of coping strategies across different stressful situations. METHODS:A matched case-contr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199911000-00011
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Trauma is associated with increased risk for anxiety disorders such as posttraumatic stress disorder (PTSD). To further understand biologic mechanisms of PTSD, we examined the dark-enhanced startle response, a psychophysiological correlate of anxiety, and heart rate variability (HRV) in traumatized individual...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318240803a
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Both depression and anxiety have been associated with poor prognosis in patients with acute coronary syndrome (ACS). However, certain symptoms and how they are measured may be more important than others. We investigated three different scales to determine their predictive validity. METHODS:Patients with ACS ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318268978e
更新日期:2012-09-01 00:00:00
abstract::Thirty-five consecutive patients with Cushing's syndrome were studied prospectively prior to treatment. A consistent constellation of psychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198102000-00002
更新日期:1981-02-01 00:00:00
abstract:OBJECTIVE:To investigate whether a support intervention (warm touch enhancement) influences physiological stress systems that are linked to important health outcomes. Growing evidence points to a protective effect of social and emotional support on both morbidity and mortality. METHODS:In this study, 34 healthy marrie...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e318187aef7
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:Altered autonomic nervous system activity is considered to be involved in the pathophysiology of somatic symptom disorder (SSD). This study aimed to investigate whether patients with SSD have disturbed autonomic activity during rest and reactivity to emotional processing and whether altered autonomic nervous ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000622
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Little is known about how patients who seek medical help for benign palpitations can be distinguished from those with clinically significant arrhythmias. This study tested whether patients with arrhythmia can be distinguished from those who are aware of sinus rhythm or extrasystoles on the basis of sex, preva...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200009000-00014
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. METHODS:Participants were 789 men and 1105 women from the ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000151745.67285.c2
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:Melissa officinalis (lemon balm) is contemporaneously used as a mild sedative and/or calming agent. Although recent research has demonstrated modulation of mood in keeping with these roles, no studies to date have directly investigated the effects of this herbal medication on laboratory-induced psychological ...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000132877.72833.71
更新日期:2004-07-01 00:00:00