Abstract:
OBJECTIVE:Trauma is associated with increased risk for anxiety disorders such as posttraumatic stress disorder (PTSD). To further understand biologic mechanisms of PTSD, we examined the dark-enhanced startle response, a psychophysiological correlate of anxiety, and heart rate variability (HRV) in traumatized individuals with and without PTSD. The associations of these measures with PTSD may be sex-specific because of their associations with the bed nucleus of the stria terminalis, a sexually dimorphic brain structure in the limbic system that is approximately 2.5 times larger in men than in women. METHODS:The study sample (N = 141) was recruited from a highly traumatized civilian population seeking treatment at Grady Memorial Hospital in Atlanta, Georgia. Psychophysiological responses during a dark-enhanced startle paradigm task included startle magnitude, assessed by eyeblink reflex, and measures of high-frequency HRV, during light and dark phases of the startle session. RESULTS:The startle magnitude was higher during the dark phase than the light phase (mean ± standard error = 98.61 ± 10.68 versus 73.93 ± 8.21 μV, p < .001). PTSD was associated with a greater degree of dark-enhanced startle in women (p = .03) but not in men (p = .38, p interaction = .48). Although HRV measures did not differ between phases, high-frequency HRV was greater in men with PTSD compared with men without PTSD (p = .02). CONCLUSIONS:This study demonstrates that the dark-enhanced paradigm provides novel insights into the psychophysiological responses associated with PTSD in traumatized civilian sample. Sex differences in altered parasympathetic and sympathetic function during anxiety regulation tasks may provide further insight into the neurobiological mechanisms of PTSD.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Kamkwalala A,Norrholm SD,Poole JM,Brown A,Donley S,Duncan E,Bradley B,Ressler KJ,Jovanovic Tdoi
10.1097/PSY.0b013e318240803asubject
Has Abstractpub_date
2012-02-01 00:00:00pages
153-9issue
2eissn
0033-3174issn
1534-7796pii
PSY.0b013e318240803ajournal_volume
74pub_type
杂志文章abstract::Osteoporosis is a common problem in postmenopausal women. It has been linked to estrogen deficiency, other neuroendocrine processes such as hypercortisolemia and male hypogonadism, nutritional deficiencies, and other mechanisms. Some of these changes have been also reported in male and female patients with mental diso...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199509000-00011
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVES:Increased cerebral blood flow during processing of acute pain has repeatedly been observed in fibromyalgia syndrome. The study investigated the time dynamics of the pain-related hemodynamic response in fibromyalgia using transcranial Doppler sonography. METHODS:In 25 women with fibromyalgia and 25 healthy p...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182676d08
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Little is known about how patients who seek medical help for benign palpitations can be distinguished from those with clinically significant arrhythmias. This study tested whether patients with arrhythmia can be distinguished from those who are aware of sinus rhythm or extrasystoles on the basis of sex, preva...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200009000-00014
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:The effect of stress exposures and mental health sequelae on health-related outcomes is understudied among older women veterans. We examined a) the impact of wartime stress exposures on later-life functioning and disability in Vietnam-era women veterans and b) the extent to which mental health conditions know...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000762
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine whether enterotypes in the gut microbiome could be determined by clustering validity indexes and whether these enterotypes were associated with individual differences in temperament traits. METHODS:Sixty healthy Korean participants (21 men; 27.5 [8.1] years, 39 women;...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000459
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Evidence regarding the status of job strain as a risk factor for coronary heart disease (CHD) is mixed, including both results supporting the risk status and null findings. However, previous studies have typically assessed job strain at one point in time only. We examined whether the failure of such measureme...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000221252.84351.e2
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To understand the mechanisms underlying chronic interpersonal difficulties and their detrimental influence on mental and physical health. METHODS:A total of 103 healthy young women (mean age = 17 years) were administered a structured interview to assess the degree of chronic interpersonal stress in their liv...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318190d7de
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Shift-and-persist is a resilience construct hypothesized to be beneficial to physical health among individuals with low socioeconomic status (SES). This shift-and-persist construct entails a combination of reframing stressors more positively while also enduring adversity through finding purpose in life. In th...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/psy.0000000000000157
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To examine the cross-sectional association between hostility and measures of abdominal fat (visceral, subcutaneous) in middle-aged African American and white women. Because fat-patterning characteristics are known to differ by race, we were particularly interested in examining whether these associations were ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181ad13a7
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Depression and anxiety are considered risk factors for cardiovascular disease (CVD). The explanatory mechanisms, however, are still to be characterized. One proposed pathophysiological pathway is dysregulation of the autonomic nervous system, including heightened sympathetic nervous system activity. This stud...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000144
更新日期:2015-02-01 00:00:00
abstract::Psychosocial work characteristics, such as work demand, work control, and social support at work, have been shown to be related to the development of coronary heart disease in epidemiological studies. However, the mechanisms which mediate the social and psychological effects on the cardiovascular system are not known....
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00006842-199101000-00005
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:The influence of low socioeconomic status on cardiovascular disease may be mediated in part by sustained activation of stress-related autonomic and neuroendocrine processes. We hypothesized that low socioeconomic status would be associated with heightened ambulatory blood pressure and cortisol output over th...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000035717.78650.a1
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:This study examines whether stressful negative life events and pessimism were associated with lower natural killer cell cytotoxicity (NKCC) and T cytotoxic/suppressor cell (CD8+CD3+) percentage in black women co-infected with human immunodeficiency virus Type 1 (HIV-1) and human papillomavirus (HPV), a viral ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199811000-00009
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:This study examined whether anxiety and depression were independently associated with elevated blood pressure in elderly persons. METHOD:The study group consisted of 1389 subjects aged 59 to 71 years recruited from the electoral rolls of the city of Nantes (France). Subjects completed the Center for Epidemio...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199901000-00013
更新日期:1999-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000622
更新日期:2018-10-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000337
更新日期:2016-09-01 00:00:00
abstract::To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected t...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198305000-00004
更新日期:1983-05-01 00:00:00
abstract::Fifty-eight normal adolescent Swedish boys, aged 16, provided two sets of blood samples for plasma testosterone assays as well as data on a number of personality inventories and rating scales assessing aggression, inpulsiveness, lack of frustration tolerance, extraversion, and anxiety. Physical variables such as puber...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198003000-00003
更新日期:1980-03-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31825c85ca
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To test the reactivity hypothesis using blood pressure data collected 12 years after baseline. This study examined whether blood pressure reactions to acute mental stress predicted future blood pressure resting levels, as well as the temporal drift in resting blood pressure, and whether the prediction was aff...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182359808
更新日期:2011-11-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199407000-00013
更新日期:1994-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197908000-00004
更新日期:1979-08-01 00:00:00
abstract:OBJECTIVE:To investigate the risks of acute organ dysfunction and death in intensive care unit (ICU) patients with schizophrenia. METHODS:Using a retrospective matched cohort design, we compared 203 schizophrenic patients to 2036 demographically matched (1:10) nonschizophrenic patients with first-time ICU admission be...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182280016
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:This article provides the chemical basis for the molecular modification of H1 antihistamines in the rational development of some antidepressant and antipsychotic drugs. METHODS:A review of the literature and personal experiences have been compiled. CONCLUSIONS:The contributions of many basic scientists, the...
journal_title:Psychosomatic medicine
pub_type: 历史文章,杂志文章
doi:10.1097/00006842-199909000-00002
更新日期:1999-09-01 00:00:00
abstract::Using a prospective design, this study examined the hypothesis that a predisposition to focus on internal aspects of the self serves as a stress resistance resource. One hundred and twenty subjects filled out the Private Self-Consciousness inventory, a schedule of recent life events and a symptom checklist. Two months...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198509000-00007
更新日期:1985-09-01 00:00:00
abstract::The association of peripheral arterial disease (PAD) with hostility, a component of Type A behavior, has not been investigated. Previous studies have found an association between coronary arterial disease and hostility. We used Doppler tests to define PAD as consisting of a resting index less than 0.9, absence of post...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198905000-00003
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to describe end-of-life (EOL) care in individuals with bipolar disorder (BD) who died of cancer compared with mentally healthy individuals. METHODS:This was a nationwide cohort study of all adult individuals who died of cancer in hospitals in France between 2013 and 2016. Outcomes were compa...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000839
更新日期:2020-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3180514d57
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:Biochemical host defenses at mucosal sites, such as the oral cavity, play a key role in the regulation of microbial ecology and the prevention of infectious disease. These biochemical factors have distinct features, some of which benefit the host and some that benefit bacteria. We investigated the effects of ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200001000-00006
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Despite its simplicity, single-item measures of self-rated health have been associated with mortality independent of objective health conditions. However, little is known about the mechanisms potentially responsible for such associations. This study tested the association between self-rated heath and inflamma...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000683
更新日期:2019-05-01 00:00:00