Stressful events, pessimism, natural killer cell cytotoxicity, and cytotoxic/suppressor T cells in HIV+ black women at risk for cervical cancer.

Abstract:

OBJECTIVE:This study examines whether stressful negative life events and pessimism were associated with lower natural killer cell cytotoxicity (NKCC) and T cytotoxic/suppressor cell (CD8+CD3+) percentage in black women co-infected with human immunodeficiency virus Type 1 (HIV-1) and human papillomavirus (HPV), a viral initiator of cervical cancer. METHOD:Psychosocial interviews, immunological evaluations, and cervical swabs for HPV detection and subtyping were conducted on 36 HIV+ African-American, Haitian, and Caribbean women. RESULTS:Greater pessimism was related to lower NKCC and cytotoxic/suppressor cells after controlling for presence/absence of HPV Types 16 or 18, behavioral/lifestyle factors, and subjective impact of negative life events. CONCLUSIONS:A pessimistic attitude may be associated with immune decrements, and possibly poorer control over HPV infection and increased risk for future promotion of cervical dysplasia to invasive cervical cancer in HIV+ minority women co-infected with HPV.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Byrnes DM,Antoni MH,Goodkin K,Efantis-Potter J,Asthana D,Simon T,Munajj J,Ironson G,Fletcher MA

doi

10.1097/00006842-199811000-00009

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

714-22

issue

6

eissn

0033-3174

issn

1534-7796

journal_volume

60

pub_type

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