Abstract:
OBJECTIVE:To examine the association of anxiety with incident dementia and cognitive impairment not dementia (CIND). METHODS:We conducted a prospective study of men aged 48 to 67 years at baseline anxiety assessment; we measured cognition 17 years later. We studied 1481 men who were either eligible for examination or were known to have dementia. Trait Anxiety was assessed using the Spielberger State Trait Anxiety Inventory. Psychological distress was assessed using the 30-item general health questionnaire. Cognitive screening was followed by a clinical examination. Medical notes and death certificates of those not seen were also examined. Outcomes were CIND and Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) dementia. RESULTS:Of 1160 men who were cognitively screened, 174 cases of CIND and 69 cases of dementia were identified. A further 21 cases of dementia were identified from medical records. After adjustment for age, vascular risk factors and premorbid cognitive function associations with higher anxiety (31st-95th centile) were for CIND odds ratio (OR) 2.31 (95% Confidence Interval (CI) = 1.20-4.44) and for dementia OR 2.37 (95% CI = 0.98-5.71). These associations were slightly stronger for nonvascular (OR = 2.45; 95% CI = 1.28-4.68) than for vascular impairment (OR = 1.94; 95% CI = 0.77-4.89). Analyses of change in cognitive performance, assessed by the Cambridge Cognitive Examination of the Elderly subscales found some evidence for decline in learning memory with higher anxiety score (b(age adj) = -0.291 (-0.551, -0.032), but not for any other subscale. CONCLUSIONS:Anxiety is a risk factor for CIND and dementia. The extent to which the association is independent of depression and whether or not it is causal requires further study.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Gallacher J,Bayer A,Fish M,Pickering J,Pedro S,Dunstan F,Ebrahim S,Ben-Shlomo Ydoi
10.1097/PSY.0b013e3181a6177csubject
Has Abstractpub_date
2009-07-01 00:00:00pages
659-66issue
6eissn
0033-3174issn
1534-7796pii
PSY.0b013e3181a6177cjournal_volume
71pub_type
杂志文章abstract::This investigation assessed the syndromal nature of menstrual cycle changes in women who experience significant cyclicity of mood by exploring the time course of different symptoms in relation to endocrinologically defined segments of the menstrual cycle. Participants were accepted into the protocol on the basis of a ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198903000-00007
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between cardiac self-efficacy and health status, including symptom burden, physical limitation, quality of life, and overall health among outpatients with stable coronary heart disease (CHD). We hypothesized that lower self-efficacy would predict worse health status, independent of...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3180514d57
更新日期:2007-05-01 00:00:00
abstract::This study investigated the relationship between anxiety and coronary artery disease (CAD). State (S-ANX) and trait (T-ANX) anxiety were assessed with the State-Trait Personality Inventory (STPI), which was administered to 373 patients (230 males, 143 females) 12 to 18 hr prior to their undergoing coronary arteriograp...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198703000-00002
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:The natural course of elevated depressive symptoms or subthreshold depression in patients with an acute coronary syndrome (ACS) is presented, as is the prognostic impact. Safe and effective psychological treatment options are desirable for subthreshold depression in patients with ACS, should they prove tolera...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/01.psy.0000116716.19848.65
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Depression and anxiety have been inconsistently associated with diabetes. Sex differences in the biological and behavioral correlates of these forms of distress could partially explain these inconsistencies. We investigated sex-specific associations between depression/anxiety symptoms and diabetes in two sep...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000169
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:This study was designed to determine whether pseudoexacerbations and confirmed MS exacerbations are preceded by or concurrent with increased anxiety or depressive symptoms. METHODS:This was a secondary analysis of 121 patients with MS who were observed for 48 weeks during a randomized controlled trial. Parti...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e3182757b2b
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:This study assessed the relation of stressful life events with survival after breast cancer. METHODS:This study was based on women with histologically confirmed, newly diagnosed, localized or regional stage breast cancer first treated in 1 of 11 Quebec City (Canada) hospitals from 1982 through 1984. Among 76...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200103000-00017
更新日期:2001-03-01 00:00:00
abstract::Symptomatic individuals suspected of having myocardial ischemia often have no obstructive atherosclerotic narrowing of epicardial coronary arteries. Abnormal coronary vascular reactivity and, in particular, coronary artery vasospasm (CAS) may be an explanation in a subset of these patients. Psychological factors play ...
journal_title:Psychosomatic medicine
pub_type: 评论,杂志文章
doi:10.1097/PSY.0000000000000682
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To investigate efficacy and safety of St. John's wort (SJW) LI 160 in somatoform disorders. METHODS:In a prospective, randomized, placebo-controlled, and double-blind parallel group study, 184 outpatients with somatization disorder (ICD-10 F45.0), undifferentiated somatoform disorder (F45.1), and somatoform ...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000128900.13711.5b
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To analyze in a prospective cohort study if depressive symptoms are an independent predictor of mortality in kidney transplant recipients. METHODS:Data from 840 transplanted patients followed at a single outpatient transplant center were analyzed. Sociodemographic parameters and clinical data were collected ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181dbbb7d
更新日期:2010-07-01 00:00:00
abstract::Although increased morbidity and mortality have been reliably associated with social isolation and less satisfying personal relationships, relatively little is known about the underlying biopsychosocial mechanisms. We assessed problem-solving behaviors and changes in immune function in 90 newlywed couples who were adm...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199309000-00001
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To examine whether the 1-year prevalence of major depressive disorder (MDD), generalized anxiety disorder (GAD), and their comorbidity were associated with subsequent all-cause and cardiovascular disease (CVD) mortality during 15 years in Vietnam veterans. METHODS:Participants (N = 4256) were from the Vietna...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31819e6706
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:This study examined whether anxiety and depression were independently associated with elevated blood pressure in elderly persons. METHOD:The study group consisted of 1389 subjects aged 59 to 71 years recruited from the electoral rolls of the city of Nantes (France). Subjects completed the Center for Epidemio...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199901000-00013
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Lesbian, gay, and bisexual (LGB) individuals-particularly those who have not disclosed their sexual orientation-are believed to experience increased chronic stress in comparison with heterosexuals. This interdisciplinary study assessed whether psychiatric symptoms (self-rated anxiety, depression, and burnout...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182826881
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Despite its simplicity, single-item measures of self-rated health have been associated with mortality independent of objective health conditions. However, little is known about the mechanisms potentially responsible for such associations. This study tested the association between self-rated heath and inflamma...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000683
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:To examine ethnic differences in pain sensitivity and relationship of pain tolerance to blood pressure and neuroendocrine factors. METHODS:Fifty-one African Americans (24 men, 27 women) and 55 people from other ethnic groups (primarily Caucasian; 26 men, 29 women) were tested twice for pain sensitivity to t...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000188466.14546.68
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:Hypnotic suggestion is an empirically validated form of pain control; however, the underlying mechanism remains unclear. METHODS:Thirteen fibromyalgia patients received suggestions to alter their clinical pain, and 15 healthy controls received suggestions to alter experimental heat pain. Suggestions were del...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000370
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To examine whether increased sleep during viral or bacterial infections supports host defense mechanisms. METHODS:To test this assumption in humans, healthy male subjects were assigned either to sleep from 2300 to 0700 hours (n = 10) or to stay awake through the night (n = 10). In the sleeping subjects Salmo...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-200107000-00008
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:Ambulatory saliva collections for subsequent analysis of free cortisol levels are now frequently applied to measure adrenocortical activity in healthy subjects and patient populations. Despite the prime importance of accurate timing of saliva collection outside the laboratory, no data are available on the com...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000058374.50240.bf
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To examine the association between the experience of daily interpersonal stress and levels of C-reactive protein (CRP), an inflammatory marker that is a key indicator of cardiovascular risk, during the teenage years. METHODS:A total of 69 adolescents (Mage= 17.78 years) completed daily diary checklists each ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181921b1f
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Prior attempts to measure psychological responses to exercise are potentially limited by a failure to account for participants' expectations, the absence of a valid exercise placebo, and demand characteristics. The purpose of this study was to explore the main and interactive effects of a manipulation designe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000381
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:This study investigated whether altruistic social interest behaviors such as engaging in helping others were associated with better physical and mental health in a stratified random sample of 2016 members of the Presbyterian Church throughout the United States. METHODS:Mailed questionnaires evaluated giving ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000079378.39062.d4
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:To document changes in Axis I psychiatric disorders after bariatric surgery and examine their relationship with postsurgery weight loss. METHODS:As part of a three-site substudy of the Longitudinal Assessment of Bariatric Surgery Research Consortium, 199 patients completed the Structured Clinical Interview ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000277
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess the effects of participation in a mindfulness meditation-based stress reduction program on mood disturbance and symptoms of stress in cancer outpatients. METHODS:A randomized, wait-list controlled design was used. A convenience sample of eligible cancer patients enro...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-200009000-00004
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:This article reports a case series of atypical sexual behavior during sleep, which is often harmful to patients or bed partners. METHODS:Eleven subjects underwent clinical evaluation of complaints of sleep-related atypical sexual behavior. Complaints included violent masturbation, sexual assaults, and contin...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200203000-00017
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To examine whether socioeconomic status (SES) (education, occupation, income), is associated both cross sectionally and prospectively with circulating concentrations of a) two correlates of oxidative damage, F(2)-isoprostanes (F(2)-IsoPs) and gamma-glutamyltransferase (GGT); and b) antioxidant nutrients (asco...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31819e7526
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:This case report describes the use of sacral neuromodulation to treat urinary retention after sexual abuse. METHODS:Sacral neuromodulation was added to therapeutic regimen of a 38-year-old woman in whom chronic, complete urinary retention developed after psychological and sexual abuse during childhood. RESU...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200105000-00022
更新日期:2001-05-01 00:00:00
abstract::Insomnia is common among patients who subsequently experience an acute myocardial infarction (MI), and is a major symptom of psychiatric depression. The purpose of this study was to determine what proportion of patients reporting insomnia prior to MI have depression. Of 70 patients with a recent MI, 27 (39%) reported ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199011000-00001
更新日期:1990-11-01 00:00:00
abstract::A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance ...
journal_title:Psychosomatic medicine
pub_type: 评论,社论
doi:10.1097/PSY.0000000000000373
更新日期:2016-09-01 00:00:00
abstract::Previous research has suggested that patients with amyotrophic lateral sclerosis (ALS) demonstrate similar psychological characteristics that distinguish them from the medically ill populations, and that these findings may bear etiologic and prognostic importance. In this report, a larger sample was studied and the pr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197709000-00003
更新日期:1977-09-01 00:00:00