Abstract:
OBJECTIVES:The influence of low socioeconomic status on cardiovascular disease may be mediated in part by sustained activation of stress-related autonomic and neuroendocrine processes. We hypothesized that low socioeconomic status would be associated with heightened ambulatory blood pressure and cortisol output over the working day. METHODS:One hundred eight men and 94 women from the Whitehall II epidemiological cohort participated. Blood pressure and heart rate were monitored every 20 minutes over a working day and evening, and salivary cortisol was sampled on waking up and at 2-hour intervals. Measures were also taken under resting laboratory conditions. Socioeconomic status was indexed by grade of employment. RESULTS:Resting blood pressure, heart rate, and cortisol did not differ by grade. Ambulatory systolic pressure was greater in the morning in the lower (128.9 +/- 15.7 mm Hg) than the intermediate (122.6 +/- 12.5 mm Hg) and higher grades (123.3 +/- 12.7 mm Hg) after adjustment for age, sex, smoking, and alcohol intake (p =.019). Heart rate was also raised in the morning in the lower grade participants. Differences in morning systolic pressure and heart rate were independent of concurrent physical activity. Cortisol concentration was greater in lower than higher grade men (9.54 +/- 4.1 vs. 7.38 +/- 2.8 nmol/liter, p =.008) but was more elevated in higher than lower grade women (7.84 +/- 2.5 vs. 6.35 +/- 1.9 nmol/liter, p =.014). Differences remained significant after adjustment for age, time of awakening, smoking, and alcohol intake. CONCLUSIONS:Socioeconomic differences in blood pressure and cortisol may reflect stress-related activation of biological pathways that contribute to variations in disease risk.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Steptoe A,Kunz-Ebrecht S,Owen N,Feldman PJ,Willemsen G,Kirschbaum C,Marmot Mdoi
10.1097/01.psy.0000035717.78650.a1subject
Has Abstractpub_date
2003-05-01 00:00:00pages
461-70issue
3eissn
0033-3174issn
1534-7796journal_volume
65pub_type
杂志文章abstract:OBJECTIVE:The main aims of this study were a) to investigate the relationship between lightheadedness and cerebral blood flow velocity (CBFv) during hyperventilation-induced hypocapnia, and b) to investigate whether and why the relationship between lightheadedness and CBFv may change after several episodes of this sens...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181e68e94
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the evidence for an association between cesarean section and postpartum depression. METHODS:Medline and PsychInfo databases were searched. All studies on cesarean section that evaluated maternal mood between 10 days and 1 year after delivery were reviewed. Nine meth...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/01.psy.0000204787.83768.0c
更新日期:2006-03-01 00:00:00
abstract::The prevalence of essential hypertension is higher among blacks than whites. One reason for this difference may be that blacks are more reactive to stressors that produce vasoconstrictive responses. Two studies were conducted to test this hypothesis, one with 10- to 14-year-old males (20 whites, 20 blacks) and one wit...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199005000-00003
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:We sought to determine whether irritable bowel syndrome (IBS) was associated with attentional bias toward symptom-related cues in IBS patients versus healthy controls, using a modified Stroop task to measure selective processing of gastrointestinal symptom-related cues. METHODS:Fifteen patients with a clini...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000232270.78071.28
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To understand the mechanisms underlying chronic interpersonal difficulties and their detrimental influence on mental and physical health. METHODS:A total of 103 healthy young women (mean age = 17 years) were administered a structured interview to assess the degree of chronic interpersonal stress in their liv...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318190d7de
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To identify patterns and predictors of work status and number of hours employed in a group of men with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). METHODS:A total of 141 participants had semiannual neuropsychiatric, psychosocial, and medical assessments over a period of 30 m...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000108083.43147.6d
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:Recent academic debate has centered on whether functional somatic syndromes should be defined as separate entities or as one syndrome. The aim of this study was to investigate whether there may be significant differences in the etiology or precipitating factors associated with two common functional syndromes...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000221384.07521.05
更新日期:2006-05-01 00:00:00
abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198411000-00003
更新日期:1984-11-01 00:00:00
abstract::Serial sampling of peripheral blood from six healthy adult male volunteers was performed during daytime waking and nighttime sleeping. In addition, sleep physiology was assessed in all subjects (Ss) and sleep stages scored blind by standard criteria. Samples of plasma were analyzed for cortisol (Co) levels, functional...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198605000-00001
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to assess whether socioeconomic status (SES) is associated with dysregulation of the cortisol diurnal rhythm and whether this association is independent of race and occurs equally in whites and blacks; and to determine if an association between SES and cortisol can be explai...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000195967.51768.ea
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a poss...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000137
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES AND METHODS:Self-report studies have shown an association between music performance anxiety (MPA) and hyperventilation complaints. However, hyperventilation was never assessed physiologically in MPA. This study investigated the self-reported affective experience, self-reported physiological symptoms, and car...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31825e3578
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the cortisol response during the first hour in the morning with strict reference to the time of awakening was established as a reliable marker of individual adrenocortical activ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000040950.22044.10
更新日期:2003-01-01 00:00:00
abstract::Thirty adults willing their body at death to medical science were compared on a number of personality variables with 30 nondonors, both groups equated for age, education, and socioeconomic status. Donors are internally directed, masters of their fate; nondonors rely on chance or luck to explain outcome. A more defin...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197507000-00004
更新日期:1975-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the construct validity of the five-item Women's Health Initiative Insomnia Rating Scale (WHIIRS) by comparing women taking hormone therapy (HT) versus those taking a placebo and by comparing women known to differ in vasomotor symptoms. METHODS:The WHIIRS was includ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/01.psy.0000151743.58067.f0
更新日期:2005-01-01 00:00:00
abstract::A number of psychosomatic studies have suggested that alexithymia, impairment in identifying and expressing inner feelings, might somehow affect the course of various illnesses. However, none of these studies have distinguished between an impact of alexithymia on actual pathophysiological change versus an impact only ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199405000-00010
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder (MDD) is associated with more pain complaints and an altered pain perception. Studies regarding the longitudinal relationship between depressive symptoms and pain processing have rarely been performed and have produced inconsistent results. To clarify how short-term alleviation of de...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e31815c1b5d
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Research suggests that individuals with posttraumatic stress disorder (PTSD) are more likely to develop medical conditions and other stress-related psychiatric disorders. Given these findings and others suggesting that PTSD victims may have altered neuroendocrine and immune systems, the hypothesis that Vietn...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章
doi:10.1097/00006842-199905000-00019
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:Fatigue is a common problem among cancer patients and survivors, yet the mechanisms underlying the occurrence and persistence of this symptom are not known. Activation of the immune system may evoke feelings of fatigue, which are mediated by proinflammatory cytokines. We examined whether fatigued breast cance...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200207000-00010
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:This study examined the effect of synthetic oxytocin delivered intranasally on acute pain sensitivity using a placebo-controlled, double-blind, within-participant crossover design. METHODS:Thirty-seven (18 were male) pain-free young adults underwent two laboratory sessions separated by 1 week. Each session ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000068
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To test whether the association between depression and inflammation differs by race and sex. Depressive symptoms have been associated with higher levels of C-reactive protein (CRP). However, few studies have examined this association in samples including a significant number of African Americans, or examined ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318222379c
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Ambulatory saliva collections for subsequent analysis of free cortisol levels are now frequently applied to measure adrenocortical activity in healthy subjects and patient populations. Despite the prime importance of accurate timing of saliva collection outside the laboratory, no data are available on the com...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000058374.50240.bf
更新日期:2003-03-01 00:00:00
abstract::A sample of 45 patients with a history of coronary heart disease and documented myocardial ischemia during exercise testing were evaluated in an investigation of the possible relationships between psychological factors (depression and Type A behavior pattern), plasma beta-endorphin response and pain experience during ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199111000-00007
更新日期:1991-11-01 00:00:00
abstract::Relationships of psychosocial factors (anger, hostility, hassles, and caregiving) with fasting insulin and glucose levels were examined. Samples included two groups of nondiabetic adults (mean age = 69.4 years): spouse caregivers (CG) of individuals with diagnoses of Alzheimer's disease (AD) (N = 78) and spouses of no...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199609000-00011
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:The study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate during workday activities. METHODS:Healthy, nonsmoking, habitual coffee drinkers (N = 21) received daily doses of 100 mg and 500 mg of caffeine on 2 days in a crossover design. Treatment order was ran...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199805000-00019
更新日期:1998-05-01 00:00:00
abstract::Social support is defined as information leading the subject to believe that he is cared for and loved, esteemed, and a member of a network of mutual obligations. The evidence that supportive interactions among people are protective against the health consequences of life stress is reviewed. It appears that social sup...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197609000-00003
更新日期:1976-09-01 00:00:00
abstract:OBJECTIVE:Altered autonomic nervous system activity is considered to be involved in the pathophysiology of somatic symptom disorder (SSD). This study aimed to investigate whether patients with SSD have disturbed autonomic activity during rest and reactivity to emotional processing and whether altered autonomic nervous ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000622
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesize that psoriasis patients treated under a partial schedule of pharmacologic (corticosteroid) reinforcement would show less severe symptoms and relapse than those given the same amount of drug under standard conditions. Behavioral conditioning as an inherent component of many pharmacother...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/PSY.0b013e3181cbd38b
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Somatic symptom disorder (SSD) often co-occurs with major depressive disorder (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional brain connectivity betwee...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000490
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Perceived discrimination has been associated with psychosocial distress and adverse health outcomes. We examined associations of perceived discrimination measures with changes in kidney function in a prospective cohort study, the Healthy Aging in Neighborhoods of Diversity across the Life Span. METHODS:Our s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000478
更新日期:2017-09-01 00:00:00