当前位置： SCI文献检索 > PSYCHOSOMATIC MEDICINE期刊下所有文献 > Conditioned pharmacotherapeutic effects: a preliminary study.

Conditioned pharmacotherapeutic effects: a preliminary study.

Abstract：

OBJECTIVE:To test the hypothesize that psoriasis patients treated under a partial schedule of pharmacologic (corticosteroid) reinforcement would show less severe symptoms and relapse than those given the same amount of drug under standard conditions. Behavioral conditioning as an inherent component of many pharmacotherapeutic protocols has never been examined. METHODS:A double-blind, simple randomization intervention was conducted with 46 patients from California and New York. Initially, lesions were treated with 0.1% acetonide triamcinolone under standard treatment conditions. Thereafter, a Standard Therapy group continued on continuous reinforcement (active drug every treatment) with 100% of the initial dose; Partial Reinforcement patients received a full dose 25% to 50% of the time and placebo medication other times; Dose Control patients received continuous reinforcement with 25% to 50% of the initial dose. RESULTS:Severity of disease scores in California neither supported nor refuted the hypothesis. In New York, where there was no difference between Partial Reinforcement and Dose Control groups at baseline, partial reinforcement effected a greater reduction in lesion severity than Dose Control conditions and did not differ from Standard Therapy patients receiving two to four times more drug. For the entire population, the frequency of relapse under partial reinforcement (26.7%) was lower than in Dose Control patients (61.5%) and did not differ from full-dose treatment (22.2%). CONCLUSIONS:A partial schedule of pharmacotherapeutic reinforcement could maintain psoriasis patients with a cumulative amount of corticosteroid that was relatively ineffective when administered under standard treatment conditions. Conceivably, corticosteroid administration only one quarter or half as frequently as currently prescribed is sufficient to treat psoriasis. We posit, however, that these preliminary observations implicate conditioning processes in-and for the design of-regimens of pharmacotherapy.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Ader R,Mercurio MG,Walton J,James D,Davis M,Ojha V,Kimball AB,Fiorentino D

doi

10.1097/PSY.0b013e3181cbd38b

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

192-7

issue

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3181cbd38b

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

在线工具

Conditioned pharmacotherapeutic effects: a preliminary study.