Pancreatic abnormalities in patients with eating disorders.

Abstract:

:In patients with eating disorders, we evaluated pancreatic abnormalities using serum elastase 1 measurement by RIA and the 50 g oral glucose tolerance test (50 g OGTT). Twenty-one patients had anorexia nervosa (AN) with bulimia and vomiting (AN-B group), 30 had AN without bulimia or vomiting (AN-R group), and 25 had bulimia with normal body weight (B group). The serum elastase 1 level was determined on admission and repeated after body weight gain in 43 anorectic patients. The 50 g OGTT was performed within 2 weeks after admission. The serum elastase 1 level in the AN-B group (363 +/- 47 ng/dl, M +/- SE), and in the AN-R group (352 +/- 37) were significantly higher than that in the B group (242 +/- 18) or in the healthy female controls (191 +/- 10; n = 13). A significant decrease of serum elastase 1 was observed before and after body weight gain; however, there was no significant correlation between the serum elastase 1 level and insulin response to the 50 g OGTT. Elevation of the serum elastase 1 level in AN suggests pancreatic abnormalities other than those related to endocrinological events.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Kobayashi N,Tamai H,Uehata S,Komaki G,Mori K,Matsubayashi S,Nakagawa T

doi

10.1097/00006842-198811000-00007

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

607-14

issue

6

eissn

0033-3174

issn

1534-7796

journal_volume

50

pub_type

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