Impact of Time Lapse on ASCP Board of Certification Medical Laboratory Scientist (MLS) and Medical Laboratory Technician (MLT) Examination Scores.

abstract：OBJECTIVE:To investigate the expression level and clinical significance of microRNA-155 (miR-155) in bladder cancer. METHODS:We collected 102 pairs of tissue specimens from patients with primary bladder cancer and adjacent normal bladder specimens between March 2008 and May 2013. Quantitative real-time polymerase chai...

journal_title：Laboratory medicine

authors： Wang H,Men CP

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To explore novel biomarkers for patients with pancreatic ductal adenocarcinoma (PDAC), from the perspective of tumor hypoxia. METHODS:We screened 29 differentially expressed and hypoxia-upregulated genes from the Oncomine database. A total of 12 secretory proteins that interact with hypoxia-inducible factor ...

journal_title：Laboratory medicine

authors： Yang L,Cui R,Li Y,Liang K,Ni M,Gu Y

更新日期：2020-07-08 00:00:00

abstract：Objective:To determine the effect of presence of high concentrations of nicotinamide adenine dinucleotide (NADH)- and nicotinamide adenine dinucleotide phosphate (NADPH)-consuming enzymes on the accuracy of glutamate dehydrogenase (GLDH) assay for ammonia. Methods:We measured ammonia concentrations using GLDH and NADH...

journal_title：Laboratory medicine

authors： Vodenicarovova M,Skalska H,Holecek M

更新日期：2017-11-08 00:00:00

abstract：:Laboratory professionals, consultants, and treating physicians may encounter discrepancies in serological testing results for numerous reasons; identifying the reason(s) for the presence of an unexpected antibody or antigen can be challenging. A question-based approach can be useful in identifying the underlying cause...

journal_title：Laboratory medicine

authors： Yudin J,Heddle NM

更新日期：2014-07-01 00:00:00

abstract：PATIENT:78-year-old African-American man. PAST MEDICAL HISTORY:Chronic lymphocytic leukemia first diagnosed in 2003, with a subsequent relapse in 2006 and another in 2010. HISTORY OF PRESENT ILLNESS:In late 2011, the patient was admitted to the hospital for cholelithiasis, at which time his treating physician inciden...

journal_title：Laboratory medicine

authors： Sartori A,Staley B,Skipper A

更新日期：2014-07-01 00:00:00

abstract：:The main clinical distinction between post-transfusion purpura (PTP) and idiopathic thrombocytopenic purpura (ITP) is the sudden development of severe thrombocytopenia in the days after transfusion. Herein, we report the case of a 53-year-old Caucasian woman who developed multiple myeloma (MM) after peripheral blood-s...

journal_title：Laboratory medicine

authors： Milito C,Masel D,Henrichs K,Schmidt AE,Kirkley S,Aljitawi O,Becker M,Blumberg N,Refaai MA

更新日期：2019-10-10 00:00:00

abstract：:As new killer-cell immunoglobulin-like receptor (KIR) alleles are discovered, a challenge in KIR typing is maintaining sensitivity and specificity. A single nucleotide polymorphism assay can be used to type functional KIR2DL1 alleles. We improved recently on the earlier method by using a higher-specificity assay. The ...

journal_title：Laboratory medicine

authors： Bari R,Schell S,Tuggle M,Leung W

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Preparation of the patient for laboratory tests is crucial. Our aim was to investigate the current practice and regional variability of recommendations regarding patient preparation for laboratory testing. METHODS:A call for data was posted by email. Spanish laboratories were invited to fill out and submit ...

journal_title：Laboratory medicine

authors： Salinas M,López-Garrigós M,Flores E,Leiva-Salinas C

更新日期：2020-05-06 00:00:00

abstract：:Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary ...

journal_title：Laboratory medicine

authors： Beech C,Kumar D,Hendrickson J,Perincheri S,Tormey C,Bahar B

更新日期：2019-07-16 00:00:00

abstract：PATIENT:47-year-old African American man. CHIEF COMPLAINT:Initially, serious finger abscess. The patient reported severe pain that was localized to that finger only. HISTORY OF PRESENT ILLNESS:His finger had become sore and then progressively more painful and swollen. PAST MEDICAL HISTORY:A few weeks earlier, the pa...

journal_title：Laboratory medicine

authors： Rausch S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To determine and optimize the sensitivity of the CellaVision DM96 automated image-analysis system in detecting platelet (PLT) clumps on blood smears and to assess the reliability of the traditional laboratory practice of examining only the feather edge of the smear for PLT clumps. METHODS:We processed 102 bl...

journal_title：Laboratory medicine

authors： Gulati G,Uppal G,Florea AD,Gong J

更新日期：2014-10-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism characterized by increased iron absorption and tissue deposition. Three loss-of-function mutations in the hemochromatosis gene (HFE), namely, C282Y (c.845G>A), H63D (c.187C>G), and S65C (c.193A>T), account for the vast majority of HH...

journal_title：Laboratory medicine

authors： Turbiville D,Du X,Yo J,Jana BR,Dong J

更新日期：2019-04-08 00:00:00

abstract：BACKGROUND:Currently, more than 45 mathematical formulas based on simple red blood cell (RBC) parameters have been proposed for differentiating between iron deficiency and thalassemia in microcytic anemia, of which 20 are relatively new and have not been thoroughly independently verified. The study goal was to verify t...

journal_title：Laboratory medicine

authors： Hoffmann JJML,Urrechaga E

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Encephalitis is caused by infection, immune mediated diseases, or primary inflammatory diseases. Of all the causative infectious pathogens, 90% are viruses or bacteria. Granulomatous amoebic encephalitis (GAE), caused by Balamuthia mandrillaris, is a rare but life-threatening disease. Diagnosis and therapy a...

journal_title：Laboratory medicine

authors： Yang Y,Hu X,Min L,Dong X,Guan Y

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:Knowledge of transfusion medicine is the key element of better transfusion practices. This deficit observed at the blood bank end on daily basis exposing the patients for redundant risk. We assessed the knowledge of transfusion medicine among post intern doctors. OBJECTIVE:To assess the knowledge of transfu...

journal_title：Laboratory medicine

authors： Kumarage S,Fernando R,Gunasekara L

更新日期：2017-02-01 00:00:00

abstract：:Myeloperoxidase (MPO) deficiency, one of the most common inherited phagocyte defects, and may exist as a transient phenomenon in combination with some clinical condition. Hematological analyzer ADVIA 2120i is used to identify the different types of leukocytes based on their size and staining properties, and by mean pe...

journal_title：Laboratory medicine

authors： Roh S,Ham JY,Song KE,Hwang N,Lee NY

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:To compare the coagulation-factor profile of cryoprecipitate produced from fresh frozen plasma from whole blood (WB) stored for 24 hours at room temperature (24CP) with that of standard cryoprecipitate (CP). METHODS:We collected 80 units of WB from healthy volunteers, of which 20 units were of each blood gr...

journal_title：Laboratory medicine

authors： Philip J,Kumarage S,Chatterjee T,Kumar S,Mallhi R

更新日期：2014-04-01 00:00:00

abstract：:Non-specific antibodies or antibodies of undetermined significance (AUS) often pose problems for a blood bank technologist and physician. It is well known that antibodies can weaken and evanesce over time, thus eluding detection by routine blood bank techniques. Special enhancement techniques exist (eg, ficin treatmen...

journal_title：Laboratory medicine

authors： Hill BC,Hanna CA,Adamski J,Pham HP,Marques MB,Williams LA 3rd

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To evaluate broad-range 16S ribosomal DNA (rDNA) polymerase chain reaction (PCR) as a rapid screening tool to detect bacterial contamination of stem-cell products. METHODS:We performed the evaluation using whole blood spiked with serially diluted bacterial-type strains. Detection sensitivity was defined as t...

journal_title：Laboratory medicine

authors： Tokuno O,Hayakawa A,Yanai T,Mori T,Ohnuma K,Tani A,Minami H,Sugimoto T

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To test a hybrid polyethylene glycol (PEG)/gel method, specifically to attempt to increase reaction strength of accidentally overdiluted anti-Cob and broadly for proof of concept. METHODS:Methods were divided into 2 basic steps: sensitization and antiglobulin (AHG) testing. Sensitization was performed with P...

journal_title：Laboratory medicine

authors： Delk AA,Gammon RR

更新日期：2020-03-10 00:00:00

abstract：:The three major causes of anemia in neonates are blood loss, decreased red blood cell production, and increased degradation of erythrocytes. Establishing the cause of anemia in a neonate born prematurely can be challenging. Clinically, fetomaternal hemorrhage (FMH) can be difficult to diagnose-the condition often pres...

journal_title：Laboratory medicine

authors： den Besten G,van der Weide K,Schuerman FABA,Michael Cotten C,Rondeel JMM

更新日期：2018-07-05 00:00:00

abstract：OBJECTIVE:To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD). METHODS:Case-control study including 50 patients with CKD and 20 healthy volunteers. RESULTS:SAM level and SAM/SAH ratio in urine were significantly lower in patients than i...

journal_title：Laboratory medicine

authors： Kruglova MP,Grachev SV,Bulgakova PO,Ivanov AV,Virus ED,Nikiforova KA,Fedoseev AN,Savina GD,Kubatiev AA

更新日期：2020-01-02 00:00:00

abstract：OBJECTIVE:Panels of clinical laboratory testing may generate "incidental" critical values from unordered parameters. Existing regulations do not clearly delineate guidelines for handling incidental critical values. The objective of this study was to examine the patterns and clinical utility of incidental critical value...

journal_title：Laboratory medicine

authors： Grieme CV,Voss DR,Olson KE,Davis SR,Kulhavy J,Krasowski MD

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of temperature and protease inhibitor on adrenocorticotrophin (ACTH) stability. METHODS:We collected blood specimens from 10 donors into K3 EDTA (ethylenediaminetetraacetic acid) and K3 EDTA + aprotinin tubes. Plasma specimens were held at room temperature and at 2 °C to 8[Formula: ...

journal_title：Laboratory medicine

authors： Turkon H,Toprak B,Yalcin H,Colak A,Ozturk N

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The production of 2 monoclonal proteins characterizes biclonal gammopathic manifestations (BGMs). The available medical literature from India is chiefly restricted to case reports. OBJECTIVE:To study the incidence of BGMs in a tertiary care center in Chandigarh, India, during a 4-year period. We evaluated t...

journal_title：Laboratory medicine

authors： Sharma S,Gupta P,Aggarwal R,Malhotra P,Minz RW,Bansal F

更新日期：2019-10-10 00:00:00

abstract：Background:Early access for routine testing with the Alinity c clinical chemistry system (Abbot Laboratories) presented the opportunity to characterize the analytical performance of multiple analytes across clinical laboratories in Europe. Methods:A total of 8 laboratories from 7 European countries evaluated 10 high-v...

journal_title：Laboratory medicine

authors： Krintus M,Fernandez JA,Chesters C,Colla R,Ford C,Frattolillo D,Köller U,Mairesse J,Jimenez DM,Motol J,Padmore K,Sharrod-Cole H,Sypniewska G

更新日期：2019-01-01 00:00:00

abstract：Background:Anti-phospholipase A2 receptor (anti-PLA2R) is a promising biomarker for diagnosis, activity evaluation, therapy monitoring, and prognostic estimation of primary membranous neuropathy (pMN). Difference in methodology may be one cause of the discrepancy in anti-PLA2R-positive percentages in reported studies. ...

journal_title：Laboratory medicine

authors： Li W,Guo Y,Zhang Z,Zhang F,Liu X,Ji X,Liu L,Wang H

更新日期：2018-10-11 00:00:00

abstract：OBJECTIVE:Platelet counts generated by automated analyzers on blood specimens that contain platelet clumps are often inaccurate and require verification by blood-smear review. In this study, we assessed the reliability of the Sysmex XE-5000 instrument to detect platelet clumps. METHOD:We reviewed automated complete bl...

journal_title：Laboratory medicine

authors： Hawkins J,Gulati G,Uppal G,Gong J

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:To determine the effect of a modified request form on the total use of γ-glutamyl transferase (GGT) usage and the ratio of inappropriate testing. METHODS:We modified a test request form by moving GGT from the "Liver profile" to the "Other" section. The criteria for appropriate GGT ordering were developed ba...

journal_title：Laboratory medicine

authors： Kobkitjaroen J,Pongprasobchai S,Tientadakul P

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To identify the osteoprotegerin (OPG) correlates with antiphospholipid syndrome (APS) parameters. METHODS:Our cohort included 40 patients with primary APS disease associated with systemic lupus erythematosus (SLE) (mean age, 43.7 years; 87% female). Data on cardiovascular risk factors and specific clinical e...

journal_title：Laboratory medicine

authors： Caraiola S,Dima A,Jurcut C,Jurcut R,Baicus C,Baicus A

更新日期：2020-03-10 00:00:00