Cryoglobulinemia as a Possible Primer for TRALI: Report of a Case.

Abstract:

:Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary complications. Cryoglobulins can also serve as a source of interference with various laboratory assays. Therapeutic plasma exchange (TPE) is one of the recommended treatment modalities to manage hyperviscosity. Herein, we present the case of an 84-year-old female patient with Waldenström macroglobulinemia who presented with hyperviscosity syndrome and discrepant laboratory findings, and who then developed transfusion-related acute lung injury (TRALI) during TPE. This case is one of many in the emerging possible linkages observed between cryoglobulinemia and TRALI.

journal_name

Lab Med

journal_title

Laboratory medicine

authors

Beech C,Kumar D,Hendrickson J,Perincheri S,Tormey C,Bahar B

doi

10.1093/labmed/lmy073

subject

Has Abstract

pub_date

2019-07-16 00:00:00

pages

313-319

issue

3

eissn

0007-5027

issn

1943-7730

pii

5292350

journal_volume

50

pub_type

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