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Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease.

Abstract：

OBJECTIVE:To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD). METHODS:Case-control study including 50 patients with CKD and 20 healthy volunteers. RESULTS:SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01). CONCLUSION:CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.

journal_name

Lab Med

journal_title

Laboratory medicine

authors

Kruglova MP,Grachev SV,Bulgakova PO,Ivanov AV,Virus ED,Nikiforova KA,Fedoseev AN,Savina GD,Kubatiev AA

doi

10.1093/labmed/lmz035

subject

Has Abstract

pub_date

2020-01-02 00:00:00

pages

80-85

issue

1

eissn

0007-5027

issn

1943-7730

pii

5524278

journal_volume

51

pub_type

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