Abstract:
Objective:To compare a manual squamous cell carcinoma antigen (SCCA) assay and an automated SCCA assay in a clinical setting. Methods:We included, in this study, a total of 158 specimens that had been tested using the manual SCCA assay. The CanAg SCC EIA assay and the Elecsys SCC were compared for their clinical settings. Results:Within-run and between-day coefficients of variation (CVs, %) were lower than 3%. Comparison of the manual and automated SCCA assays yielded good correlation. The correlation coefficient (R2) between the CanAg SCC EIA and Elecsys SCC assay results was 0.989 (P <.001) and the overall concordance rate was 94.3%. Conclusions:We report that the Elecsys SCC automated SCCA assay yielded performance comparable to that of the manual SCCA assay: the automated assay reduced the number of manual steps and test turnaround time.
journal_name
Lab Medjournal_title
Laboratory medicineauthors
Lee S,Kim J,Uh Y,Kim HS,Lee JHdoi
10.1093/labmed/lmy003subject
Has Abstractpub_date
2018-07-05 00:00:00pages
254-258issue
3eissn
0007-5027issn
1943-7730pii
4939304journal_volume
49pub_type
杂志文章abstract:OBJECTIVE:Establish whether hemolysis in samples collected from intravenous lines is influenced by catheterization site. METHODS:Blood was collected from all patients (67 total) admitted to the emergency department the same morning, through a 20-gauge catheter placed in a vein of the upper limb directly into an evacua...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/lm2xcv5sqml1ontm
更新日期:2014-04-01 00:00:00
abstract:PATIENT:44-year-old white woman. CHIEF COMPLAINTS:Cramping, nausea, shortness of breath, visual disturbances ("seeing yellow dots"). MEDICAL HISTORY:Status asthmticus, tobacco use, hypertension, migraines. PRINCIPLE LABORATORY FINDINGS:TABLES 1-7, FIGURES 1-4: . ...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmv011
更新日期:2016-02-01 00:00:00
abstract::Extremely low hemoglobin A1c (HbA1c) results below reference range are rare, and the causes and clinical implications associated with low HbA1c results are not well understood among clinical laboratorians. A case of extremely low HbA1c results was reported, in which liver cirrhosis, subacute hemorrhage and recent tran...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw050
更新日期:2017-02-01 00:00:00
abstract:PATIENT:78-year-old African-American man. PAST MEDICAL HISTORY:Chronic lymphocytic leukemia first diagnosed in 2003, with a subsequent relapse in 2006 and another in 2010. HISTORY OF PRESENT ILLNESS:In late 2011, the patient was admitted to the hospital for cholelithiasis, at which time his treating physician inciden...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMLWQDB2Q6LS7VQG
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To analyze the performance characteristics, stability, and clinical value of lipoprotein-associated phospholipase A2 (Lp-PLA2) using an enzymatic kinetic method. METHODS:The performance characteristics included reference intervals, precision, and accuracy. We assessed Lp-PLA2 stability by comparing Lp-PLA2 c...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy086
更新日期:2019-07-16 00:00:00
abstract::Herein, we present a case of extensive lymph node involvement by disseminated Cryptococcus infection developing in the immediate period after liver transplantation and initiation of immunosuppressive therapy. The patient, a 56 year old ethnicity unknown man, received a liver transplant for acute decompensated liver. B...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy021
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:To compare the coagulation-factor profile of cryoprecipitate produced from fresh frozen plasma from whole blood (WB) stored for 24 hours at room temperature (24CP) with that of standard cryoprecipitate (CP). METHODS:We collected 80 units of WB from healthy volunteers, of which 20 units were of each blood gr...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/lmv1e84uctrqqzp
更新日期:2014-04-01 00:00:00
abstract::Primary amoebic meningoencephalitis (PAM) is a rare and almost always fatal disease that is caused by Naegleria fowleri, a freshwater thermophilic amoeba. Our case involves an adolescent female who presented with fever of unknown origin. A lumbar puncture was performed, and the Wright-Giemsa and Gram stained cerebrosp...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw008
更新日期:2016-05-01 00:00:00
abstract::Hereditary hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism characterized by increased iron absorption and tissue deposition. Three loss-of-function mutations in the hemochromatosis gene (HFE), namely, C282Y (c.845G>A), H63D (c.187C>G), and S65C (c.193A>T), account for the vast majority of HH...
journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1093/labmed/lmy065
更新日期:2019-04-08 00:00:00
abstract::Antinuclear antibodies (ANAs) are autoantibodies that attack self-proteins within cell nucleus structures; their presence in serum may indicate an autoimmune disease. Also, positive ANA test results have been obtained in chronic infectious diseases, cancers, medication-related adverse events, and even healthy individu...
journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1093/labmed/lmy024
更新日期:2018-07-05 00:00:00
abstract:OBJECTIVE:To determine and optimize the sensitivity of the CellaVision DM96 automated image-analysis system in detecting platelet (PLT) clumps on blood smears and to assess the reliability of the traditional laboratory practice of examining only the feather edge of the smear for PLT clumps. METHODS:We processed 102 bl...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LM604RQVKVLRFXOR
更新日期:2014-10-01 00:00:00
abstract:Objective:To determine the effect of presence of high concentrations of nicotinamide adenine dinucleotide (NADH)- and nicotinamide adenine dinucleotide phosphate (NADPH)-consuming enzymes on the accuracy of glutamate dehydrogenase (GLDH) assay for ammonia. Methods:We measured ammonia concentrations using GLDH and NADH...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmx053
更新日期:2017-11-08 00:00:00
abstract:OBJECTIVE:Auramine-phenol stain was compared with Kinyoun's acid-fast stain to detect coccidia parasites in fecal samples from immunocompromised patients. The comparison was based on the number of detected cases, sensitivity, specificity, time required for the procedure, ease of use, interpretation, and cost. METHODS:...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/lms0wn7k7ukzcpmi
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate and compare the performances of the automated urinalysis devices UX-2000 and Cobas 6500. METHOD:A total of 258 urine specimens were collected from the routine specimen workload. We analyzed all specimens on both automated instruments and recorded the turnaround time from each method. Physical, ch...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw002
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Consanguineous marriage, a common practice in South India, increase the incidence of autosomal recessive diseases such as nonsyndromic hearing loss (NSHL) in offspring. This trend was noted in the children with hearing impairment (HI) who received cochlear implants (CI) at our University hospital in Porur, C...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz027
更新日期:2020-01-02 00:00:00
abstract:OBJECTIVE:Platelet counts generated by automated analyzers on blood specimens that contain platelet clumps are often inaccurate and require verification by blood-smear review. In this study, we assessed the reliability of the Sysmex XE-5000 instrument to detect platelet clumps. METHOD:We reviewed automated complete bl...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw016
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To explore novel biomarkers for patients with pancreatic ductal adenocarcinoma (PDAC), from the perspective of tumor hypoxia. METHODS:We screened 29 differentially expressed and hypoxia-upregulated genes from the Oncomine database. A total of 12 secretory proteins that interact with hypoxia-inducible factor ...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz063
更新日期:2020-07-08 00:00:00
abstract:BACKGROUND:Research in several professional fields has demonstrated that delays (time lapse) in taking certification examinations may result in poorer performance by examinees. Thirteen states and/or territories require licensure for laboratory personnel. A core component of licensure is passing a certification exam. A...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMNM534LIACPBZWH
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To evaluate broad-range 16S ribosomal DNA (rDNA) polymerase chain reaction (PCR) as a rapid screening tool to detect bacterial contamination of stem-cell products. METHODS:We performed the evaluation using whole blood spiked with serially diluted bacterial-type strains. Detection sensitivity was defined as t...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMKT4P9FFI2BBSIU
更新日期:2015-01-01 00:00:00
abstract::The three major causes of anemia in neonates are blood loss, decreased red blood cell production, and increased degradation of erythrocytes. Establishing the cause of anemia in a neonate born prematurely can be challenging. Clinically, fetomaternal hemorrhage (FMH) can be difficult to diagnose-the condition often pres...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy026
更新日期:2018-07-05 00:00:00
abstract:BACKGROUND:Currently, more than 45 mathematical formulas based on simple red blood cell (RBC) parameters have been proposed for differentiating between iron deficiency and thalassemia in microcytic anemia, of which 20 are relatively new and have not been thoroughly independently verified. The study goal was to verify t...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmaa030
更新日期:2020-11-02 00:00:00
abstract::Cording is a phenomenon in which acid fast bacilli grow in parallel and was previously used as a means of presumptive microscopic identification of Mycobacterium tuberculosis (TB). However, this process has been shown in multiple other nontuberculous mycobacterial (NTM) species. Here we present the case of an immunoco...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmaa082
更新日期:2020-09-21 00:00:00
abstract:Background:The misuse of statistical methods in diagnostic accuracy studies has been criticized in many publications. Objective:To assess the use and misuse of statistical methods in medical journal articles. Methods:We reviewed 141 original articles from 6 cytopathology journals published in 2014. Results:In total,...
journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1093/labmed/lmy036
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To determine the effect of a modified request form on the total use of γ-glutamyl transferase (GGT) usage and the ratio of inappropriate testing. METHODS:We modified a test request form by moving GGT from the "Liver profile" to the "Other" section. The criteria for appropriate GGT ordering were developed ba...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LM7E5LG6PWJYEFUJ
更新日期:2015-07-01 00:00:00
abstract:PATIENT:66-year-old ethnic Egyptian man. CHIEF COMPLAINT:Hematuria. HISTORY OF PRESENT ILLNESS:The patient had a history of multiple episodes of gross hematuria for the past 5 years. Because the hematuria usually resolved on its own, he did not seek medical attention during that time. Bladder cancer was suspected. P...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LM96EJPPBYADIOVC
更新日期:2015-10-01 00:00:00
abstract::Tacrolimus (Tac) is an immunosuppressive drug that is used in preventing organ and tissue rejection in patients after transplantation. Tac administration requires frequent and diligent monitoring by physicians to ensure proper dosage and to limit the potential for harmful adverse effects, which can include renal damag...
journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1093/labmed/lmx056
更新日期:2017-11-08 00:00:00
abstract::Hormographiella is a rare fungal pathogen in humans; however, case reports have described disseminated infection in immunocompromised hosts. This pathogen has been described to yield poor prognosis in patients who harbor it. Herein, we present a case report of autopsy-proven disseminated Hormographiella aspergillata i...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz018
更新日期:2019-10-10 00:00:00
abstract::Cell-derived microparticles (MPs) are small fragments released from various cells when they are activated or undergo apoptosis. In the field of transfusion medicine, a number of studies have documented increased levels of MPs in blood products, which have been associated with multiple factors, including donor variabil...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz100
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD). METHODS:Case-control study including 50 patients with CKD and 20 healthy volunteers. RESULTS:SAM level and SAM/SAH ratio in urine were significantly lower in patients than i...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz035
更新日期:2020-01-02 00:00:00
abstract:PATIENT:47-year-old African American man. CHIEF COMPLAINT:Initially, serious finger abscess. The patient reported severe pain that was localized to that finger only. HISTORY OF PRESENT ILLNESS:His finger had become sore and then progressively more painful and swollen. PAST MEDICAL HISTORY:A few weeks earlier, the pa...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMX711TANCVDHZJJ
更新日期:2014-07-01 00:00:00