Establishing the Cause of Anemia in a Premature Newborn Infant.

Abstract:

:The three major causes of anemia in neonates are blood loss, decreased red blood cell production, and increased degradation of erythrocytes. Establishing the cause of anemia in a neonate born prematurely can be challenging. Clinically, fetomaternal hemorrhage (FMH) can be difficult to diagnose-the condition often presents only after the manifestation of severe fetal anemia. FMH can be confirmed by determining the fetal hemoglobin F fraction in the mother, which is traditionally performed using the Kleihauer-Betke test (KBT). Herein, we present a case study of a newborn baby boy of Dutch ethnicity with massive FMH and negative KBT result. The KBT result appeared to be false-negative due to AO antagonism. However, the results of an additional marker alpha-fetoprotein (AFP) test confirmed the diagnosis of massive FMH. Therefore, measuring AFP in maternal blood can be helpful in confirming FMH in unexplained anemia of the neonate.

journal_name

Lab Med

journal_title

Laboratory medicine

authors

den Besten G,van der Weide K,Schuerman FABA,Michael Cotten C,Rondeel JMM

doi

10.1093/labmed/lmy026

subject

Has Abstract

pub_date

2018-07-05 00:00:00

pages

e74-e77

issue

3

eissn

0007-5027

issn

1943-7730

pii

5032509

journal_volume

49

pub_type

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