Abstract:
:Hormographiella is a rare fungal pathogen in humans; however, case reports have described disseminated infection in immunocompromised hosts. This pathogen has been described to yield poor prognosis in patients who harbor it. Herein, we present a case report of autopsy-proven disseminated Hormographiella aspergillata infection, confirmed by DNA sequencing, in a patient experiencing a relapse of leukemia. This 54-year-old Caucasian man with chronic myelogenous leukemia (CML) that had been diagnosed in 1989, after having received a hematopoietic cell allotransplant from a compatible sibling donor, had B-cell lymphoid-blast phase of CML in April of 2013, with multiple relapses. His most recent relapse was in September of 2016, when bone marrow biopsy showed 90% blasts. The results of bronchoalveolar lavage (BAL) cultures were positive for filamentous fungus infection. The patient developed encephalopathy and worsening respiratory statusand tachycardia with flutter and hypotension, which resulted in his death. At autopsy, bilateral pleural effusions, multiple right pleural nodules, and subarachnoid hemorrhage were noted. Angioinvasive hyphal fungi were found in the right frontal lobe of the brain and the right upper lobe of the lung. Morphologically, the fungi had multiseptate, branching hyphae. The bronchoalveolar lavage specimen grew a fungus for which the colony morphologic characteristics and microscopic features were compatible with a Hormographiella species. H. aspergillata from the bronchoalveolar lavage was further identified by sequencing the D2 hypervariable region of the large-subunit (LSU) ribosomal DNA gene and the full internal transcribed spacer (ITS) regions.
journal_name
Lab Medjournal_title
Laboratory medicineauthors
Chauhan A,Gruenberg J,Arbefeville S,Mettler T,Brent CH,Ferrieri Pdoi
10.1093/labmed/lmz018subject
Has Abstractpub_date
2019-10-10 00:00:00pages
426-431issue
4eissn
0007-5027issn
1943-7730pii
5486611journal_volume
50pub_type
杂志文章abstract:Objective:To compare a manual squamous cell carcinoma antigen (SCCA) assay and an automated SCCA assay in a clinical setting. Methods:We included, in this study, a total of 158 specimens that had been tested using the manual SCCA assay. The CanAg SCC EIA assay and the Elecsys SCC were compared for their clinical setti...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy003
更新日期:2018-07-05 00:00:00
abstract::In the past few years, interest has increased in cell-derived microparticles (MPs), which are defined by their size of from 0.1 to 1 μm, and can be derived from various cell types, including endothelial cells, leukocytes, red blood cells (RBCs), and platelets. These MPs carry negatively charged phosphatidylserine (PS)...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmaa043
更新日期:2020-08-20 00:00:00
abstract:OBJECTIVE:Tyrosine kinase inhibitors (TKIs) are considered standard first-line treatment in patients with chronic myeloid leukemia. Because ABL kinase domain mutations are the most common causes of treatment resistance, their prevalence and assessment during treatment may predict subsequent response to therapy. METHOD...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmaa052
更新日期:2020-08-21 00:00:00
abstract::Hereditary hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism characterized by increased iron absorption and tissue deposition. Three loss-of-function mutations in the hemochromatosis gene (HFE), namely, C282Y (c.845G>A), H63D (c.187C>G), and S65C (c.193A>T), account for the vast majority of HH...
journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1093/labmed/lmy065
更新日期:2019-04-08 00:00:00
abstract::Antinuclear antibodies (ANAs) are autoantibodies that attack self-proteins within cell nucleus structures; their presence in serum may indicate an autoimmune disease. Also, positive ANA test results have been obtained in chronic infectious diseases, cancers, medication-related adverse events, and even healthy individu...
journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1093/labmed/lmy024
更新日期:2018-07-05 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw027
更新日期:2016-11-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMLWQDB2Q6LS7VQG
更新日期:2014-07-01 00:00:00
abstract::Cording is a phenomenon in which acid fast bacilli grow in parallel and was previously used as a means of presumptive microscopic identification of Mycobacterium tuberculosis (TB). However, this process has been shown in multiple other nontuberculous mycobacterial (NTM) species. Here we present the case of an immunoco...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmaa082
更新日期:2020-09-21 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz100
更新日期:2020-09-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz035
更新日期:2020-01-02 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LM604RQVKVLRFXOR
更新日期:2014-10-01 00:00:00
abstract::Laboratory professionals, consultants, and treating physicians may encounter discrepancies in serological testing results for numerous reasons; identifying the reason(s) for the presence of an unexpected antibody or antigen can be challenging. A question-based approach can be useful in identifying the underlying cause...
journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1309/LMEWVSNT2F3O5JDN
更新日期:2014-07-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy016
更新日期:2018-10-11 00:00:00
abstract:Objective:To determine the effect of presence of high concentrations of nicotinamide adenine dinucleotide (NADH)- and nicotinamide adenine dinucleotide phosphate (NADPH)-consuming enzymes on the accuracy of glutamate dehydrogenase (GLDH) assay for ammonia. Methods:We measured ammonia concentrations using GLDH and NADH...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmx053
更新日期:2017-11-08 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz027
更新日期:2020-01-02 00:00:00
abstract:Background:Thromboelastography (TEG) has become the standard of care in liver-transplant surgery to identify real-time abnormalities in the coagulation cascade. To our knowledge, no studies have been performed to measure the intrasubject reproducibility of TEG parameters in cirrhotic patients. Objective:To perform a v...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmx041
更新日期:2018-07-05 00:00:00
abstract::Herein, we present a case of extensive lymph node involvement by disseminated Cryptococcus infection developing in the immediate period after liver transplantation and initiation of immunosuppressive therapy. The patient, a 56 year old ethnicity unknown man, received a liver transplant for acute decompensated liver. B...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy021
更新日期:2018-07-05 00:00:00
abstract:OBJECTIVE:To identify the osteoprotegerin (OPG) correlates with antiphospholipid syndrome (APS) parameters. METHODS:Our cohort included 40 patients with primary APS disease associated with systemic lupus erythematosus (SLE) (mean age, 43.7 years; 87% female). Data on cardiovascular risk factors and specific clinical e...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz051
更新日期:2020-03-10 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章,评审
doi:10.1093/labmed/lmy036
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To investigate the expression level and clinical significance of microRNA-155 (miR-155) in bladder cancer. METHODS:We collected 102 pairs of tissue specimens from patients with primary bladder cancer and adjacent normal bladder specimens between March 2008 and May 2013. Quantitative real-time polymerase chai...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMWR9CEA2K2XVSOX
更新日期:2015-04-01 00:00:00
abstract::Non-specific antibodies or antibodies of undetermined significance (AUS) often pose problems for a blood bank technologist and physician. It is well known that antibodies can weaken and evanesce over time, thus eluding detection by routine blood bank techniques. Special enhancement techniques exist (eg, ficin treatmen...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw062
更新日期:2017-02-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LM96EJPPBYADIOVC
更新日期:2015-10-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmaa069
更新日期:2020-10-03 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/lms0wn7k7ukzcpmi
更新日期:2014-01-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/lm2xcv5sqml1ontm
更新日期:2014-04-01 00:00:00
abstract::Primary amoebic meningoencephalitis (PAM) is a rare and almost always fatal disease that is caused by Naegleria fowleri, a freshwater thermophilic amoeba. Our case involves an adolescent female who presented with fever of unknown origin. A lumbar puncture was performed, and the Wright-Giemsa and Gram stained cerebrosp...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw008
更新日期:2016-05-01 00:00:00
abstract::Maintaining an in-compliance clinical laboratory takes continuous awareness and review of standards, regulations, and best practices. A strong quality assurance program and well informed leaders who maintain professional networks can aid in this necessary task. This article will discuss a process that laboratories can...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw007
更新日期:2016-05-01 00:00:00
abstract::Waldenström macroglobulinemia (WM) is a form of lymphoplasmacytic lymphoma that can cause hyperviscosity syndrome due to unchecked monoclonal antibody production. Some patients are also found to have associated cryoglobulinemia, which can cause systemic complications including vasculitis, renal disease, and pulmonary ...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy073
更新日期:2019-07-16 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmz006
更新日期:2019-10-10 00:00:00
abstract:OBJECTIVE:Because of the rapidly emerging SARS-CoV-2 pandemic and its wide public health challenges, rapid diagnosis is essential to decrease the spread. Antigen-based rapid detection tests are available; however, insufficient data about their performance are available. METHODS:The lateral-flow immunochromatographic B...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmaa104
更新日期:2020-12-07 00:00:00