Accidental diagnosis: Aeromonas infection leading to discovery of acute myeloid leukemia with meylodysplastic syndrome.

Abstract:

PATIENT:47-year-old African American man. CHIEF COMPLAINT:Initially, serious finger abscess. The patient reported severe pain that was localized to that finger only. HISTORY OF PRESENT ILLNESS:His finger had become sore and then progressively more painful and swollen. PAST MEDICAL HISTORY:A few weeks earlier, the patient had had a similar abscess on his leg; he could not recall any specific injuries other than this. He had a past history of epilepsy that is totally unrelated to this case; he had not had any episodes in more than 10 years. Otherwise, the medical history of the patient was relatively healthy: he is a nonsmoker with no history of diabetes or steroid use. SOCIAL HISTORY:Patient washed cars for a living. FAMILY HISTORY:Noncontributory. PHYSICAL EXAMINATION:Initially, the patient was sent home with a course of antibiotics (cephalexin and trimethoprim/sulfamethoxazole) and was asked to return to the hospital for follow up within two days. By the time of the follow-up visit, the antibiotic treatment had been unsuccessful, and the patient experienced more pain in the finger; the flesh of the finger was becoming black and necrotic. The patient tested positive for all myeloid markers: myeloperoxidase (MPO), CD34, CD33, CD13, CD45, human leukocyte antigen–DR subregion (HLA-DR), CD15, and CD11c. Trilinear dysplasia was indicated by the results of bone-marrow studies and peripheral blood smear testing.

journal_name

Lab Med

journal_title

Laboratory medicine

authors

Rausch S

doi

10.1309/LMX711TANCVDHZJJ

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

e96-100

issue

3

eissn

0007-5027

issn

1943-7730

pii

45/3/e96

journal_volume

45

pub_type

杂志文章
  • Correlation of Increased Expression of MicroRNA-155 in Bladder Cancer and Prognosis.

    abstract:OBJECTIVE:To investigate the expression level and clinical significance of microRNA-155 (miR-155) in bladder cancer. METHODS:We collected 102 pairs of tissue specimens from patients with primary bladder cancer and adjacent normal bladder specimens between March 2008 and May 2013. Quantitative real-time polymerase chai...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1309/LMWR9CEA2K2XVSOX

    authors: Wang H,Men CP

    更新日期:2015-04-01 00:00:00

  • Oxidized low-density lipoprotein and upregulated expression of osteonectin and bone sialoprotein in vascular smooth muscle cells.

    abstract:BACKGROUND:Oxidative stress has been associated with the progression of atherosclerosis and activation of genes that lead to increased deposition of proteins in the extracellular matrix. Bone sialoprotein (BSP) and osteonectin are proteins involved in the initiation and progression of vascular calcification. OBJECTIVE...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1309/LMUJWVQFW6CJMSOQ

    authors: Farrokhi E,Samani KG,Chaleshtori MH

    更新日期:2014-10-01 00:00:00

  • Reproducibility of TEG Parameters in Stable Cirrhotics.

    abstract:Background:Thromboelastography (TEG) has become the standard of care in liver-transplant surgery to identify real-time abnormalities in the coagulation cascade. To our knowledge, no studies have been performed to measure the intrasubject reproducibility of TEG parameters in cirrhotic patients. Objective:To perform a v...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmx041

    authors: George G,Manatasahit W,Balasubramanian M,Navarro V

    更新日期:2018-07-05 00:00:00

  • Performance Characteristics and Clinical Value of the Lipoprotein-Associated Phospholipase A2 by an Enzymatic Kinetic Method.

    abstract:OBJECTIVE:To analyze the performance characteristics, stability, and clinical value of lipoprotein-associated phospholipase A2 (Lp-PLA2) using an enzymatic kinetic method. METHODS:The performance characteristics included reference intervals, precision, and accuracy. We assessed Lp-PLA2 stability by comparing Lp-PLA2 c...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmy086

    authors: Lu M,Lv L

    更新日期:2019-07-16 00:00:00

  • Verification of 20 Mathematical Formulas for Discriminating Between Iron Deficiency Anemia and Thalassemia Trait in Microcytic Anemia.

    abstract:BACKGROUND:Currently, more than 45 mathematical formulas based on simple red blood cell (RBC) parameters have been proposed for differentiating between iron deficiency and thalassemia in microcytic anemia, of which 20 are relatively new and have not been thoroughly independently verified. The study goal was to verify t...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmaa030

    authors: Hoffmann JJML,Urrechaga E

    更新日期:2020-11-02 00:00:00

  • Following the Rules Set by Accreditation Agencies and Governing Bodies to Maintain In-Compliance Status: Applying Critical Thinking Skills When Evaluating the Need for Change in the Clinical Laboratory.

    abstract::Maintaining an in-compliance clinical laboratory takes continuous awareness and review of standards, regulations, and best practices. A strong quality assurance program and well informed leaders who maintain professional networks can aid in this necessary task. This article will discuss a process that laboratories can...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmw007

    authors: Byrne KM,Levy KY,Reese EM

    更新日期:2016-05-01 00:00:00

  • A 13-question approach to resolving serological discrepancies in the transfusion medicine laboratory.

    abstract::Laboratory professionals, consultants, and treating physicians may encounter discrepancies in serological testing results for numerous reasons; identifying the reason(s) for the presence of an unexpected antibody or antigen can be challenging. A question-based approach can be useful in identifying the underlying cause...

    journal_title:Laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1309/LMEWVSNT2F3O5JDN

    authors: Yudin J,Heddle NM

    更新日期:2014-07-01 00:00:00

  • Disseminated Hormographiella aspergillata Infection with Lung and Brain Involvement after Allogenic Hematopoietic Stem-Cell Transplantation in a 54-Year-Old Man.

    abstract::Hormographiella is a rare fungal pathogen in humans; however, case reports have described disseminated infection in immunocompromised hosts. This pathogen has been described to yield poor prognosis in patients who harbor it. Herein, we present a case report of autopsy-proven disseminated Hormographiella aspergillata i...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmz018

    authors: Chauhan A,Gruenberg J,Arbefeville S,Mettler T,Brent CH,Ferrieri P

    更新日期:2019-10-10 00:00:00

  • How Reliable Is Automated Urinalysis in Acute Kidney Injury?

    abstract:OBJECTIVE:Examination of urine sediment is crucial in acute kidney injury (AKI). In such renal injury, tubular epithelial cells, epithelial cell casts, and dysmorphic red cells may provide clues to etiology. The aim of this study was to compare automated urinalysis findings with manual microscopic analysis in AKI. MET...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmaa069

    authors: Chandrashekar V,Tarigopula A,Prabhakar V

    更新日期:2020-10-03 00:00:00

  • An Analysis of Multirules for Monitoring Assay Quality Control.

    abstract:BACKGROUND:Multirules are often employed to monitor quality control (QC). The performance of multirules is usually determined by simulation and is difficult to predict. Previous studies have not provided computer code that would enable one to experiment with multirules. It would be helpful for analysts to have computer...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmz038

    authors: Walker BS,Pearson LN,Schmidt RL

    更新日期:2020-01-02 00:00:00

  • Establishing the Cause of Anemia in a Premature Newborn Infant.

    abstract::The three major causes of anemia in neonates are blood loss, decreased red blood cell production, and increased degradation of erythrocytes. Establishing the cause of anemia in a neonate born prematurely can be challenging. Clinically, fetomaternal hemorrhage (FMH) can be difficult to diagnose-the condition often pres...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmy026

    authors: den Besten G,van der Weide K,Schuerman FABA,Michael Cotten C,Rondeel JMM

    更新日期:2018-07-05 00:00:00

  • Hypoxia-Induced TGFBI as a Serum Biomarker for Laboratory Diagnosis and Prognosis in Patients with Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVE:To explore novel biomarkers for patients with pancreatic ductal adenocarcinoma (PDAC), from the perspective of tumor hypoxia. METHODS:We screened 29 differentially expressed and hypoxia-upregulated genes from the Oncomine database. A total of 12 secretory proteins that interact with hypoxia-inducible factor ...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmz063

    authors: Yang L,Cui R,Li Y,Liang K,Ni M,Gu Y

    更新日期:2020-07-08 00:00:00

  • The Effectiveness of Temperature Versus Aprotinin in Maintaining the Preanalytical Stability of Adrenocorticotrophin.

    abstract:OBJECTIVE:To investigate the effect of temperature and protease inhibitor on adrenocorticotrophin (ACTH) stability. METHODS:We collected blood specimens from 10 donors into K3 EDTA (ethylenediaminetetraacetic acid) and K3 EDTA + aprotinin tubes. Plasma specimens were held at room temperature and at 2 °C to 8[Formula: ...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmw027

    authors: Turkon H,Toprak B,Yalcin H,Colak A,Ozturk N

    更新日期:2016-11-01 00:00:00

  • Laboratory Integration and Consolidation in a Regional Health System.

    abstract::Health systems face intense pressure to decrease costs and improve services as the health care delivery system in the United States undergoes tremendous change due to health care reform. As health systems grow, like any business, they are forced to explore standardization to realize and maintain efficient practices. C...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmw069

    authors: Cook J

    更新日期:2017-08-01 00:00:00

  • Myeloperoxidase Deficiency Manifesting as Pseudoneutropenia with Low Mean Peroxidase Index and High Monocyte Count in 4 Adult Patients.

    abstract::Myeloperoxidase (MPO) deficiency, one of the most common inherited phagocyte defects, and may exist as a transient phenomenon in combination with some clinical condition. Hematological analyzer ADVIA 2120i is used to identify the different types of leukocytes based on their size and staining properties, and by mean pe...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmz060

    authors: Roh S,Ham JY,Song KE,Hwang N,Lee NY

    更新日期:2020-03-10 00:00:00

  • Cording in Disseminated Mycobacterium chelonae Infection in an Immunocompromised Patient.

    abstract::Cording is a phenomenon in which acid fast bacilli grow in parallel and was previously used as a means of presumptive microscopic identification of Mycobacterium tuberculosis (TB). However, this process has been shown in multiple other nontuberculous mycobacterial (NTM) species. Here we present the case of an immunoco...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmaa082

    authors: Olson G,McNulty MC,Mullane K,Beavis KG,Tesic V

    更新日期:2020-09-21 00:00:00

  • Potential Use of Antigen-Based Rapid Test for SARS-CoV-2 in Respiratory Specimens in Low-Resource Settings in Egypt for Symptomatic Patients and High-Risk Contacts.

    abstract:OBJECTIVE:Because of the rapidly emerging SARS-CoV-2 pandemic and its wide public health challenges, rapid diagnosis is essential to decrease the spread. Antigen-based rapid detection tests are available; however, insufficient data about their performance are available. METHODS:The lateral-flow immunochromatographic B...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmaa104

    authors: Abdelrazik AM,Elshafie SM,Abdelaziz HM

    更新日期:2020-12-07 00:00:00

  • Standardizing Phlebotomy Job Descriptions.

    abstract:BACKGROUND:The University of Maryland Medical System, like all other medical systems, is faced with providing the highest quality care in an environment of increased demands and competition for resources. Some responses to this pressure include improved integration, coordination, and efficiency. Laboratory integration ...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmw051

    authors: Cook J

    更新日期:2017-02-01 00:00:00

  • Proof of Concept for a Polyethylene Glycol/Gel Hybrid Testing Method.

    abstract:OBJECTIVE:To test a hybrid polyethylene glycol (PEG)/gel method, specifically to attempt to increase reaction strength of accidentally overdiluted anti-Cob and broadly for proof of concept. METHODS:Methods were divided into 2 basic steps: sensitization and antiglobulin (AHG) testing. Sensitization was performed with P...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmz015

    authors: Delk AA,Gammon RR

    更新日期:2020-03-10 00:00:00

  • Prevalence and Clinical Utility of "Incidental" Critical Values Resulting From Critical Care Laboratory Testing.

    abstract:OBJECTIVE:Panels of clinical laboratory testing may generate "incidental" critical values from unordered parameters. Existing regulations do not clearly delineate guidelines for handling incidental critical values. The objective of this study was to examine the patterns and clinical utility of incidental critical value...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmw044

    authors: Grieme CV,Voss DR,Olson KE,Davis SR,Kulhavy J,Krasowski MD

    更新日期:2016-11-01 00:00:00

  • Analysis of Turnaround Time for Intraoperative Red Blood Cell Issues: A Single-Center Study.

    abstract:Background:When unpredicted surgical blood loss occurs, it is essential that blood arrive from the blood bank in a timely manner. Objective:To evaluate the turnaround time (TAT) for red blood cells (RBCs) from the blood bank to the operating suite. Cases with delayed TATs were further analyzed to determine potential c...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmx016

    authors: Lee AJ,Kim SG

    更新日期:2017-08-01 00:00:00

  • Balamuthia mandrillaris-Related Primary Amoebic Encephalitis in China Diagnosed by Next Generation Sequencing and a Review of the Literature.

    abstract:BACKGROUND:Encephalitis is caused by infection, immune mediated diseases, or primary inflammatory diseases. Of all the causative infectious pathogens, 90% are viruses or bacteria. Granulomatous amoebic encephalitis (GAE), caused by Balamuthia mandrillaris, is a rare but life-threatening disease. Diagnosis and therapy a...

    journal_title:Laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1093/labmed/lmz079

    authors: Yang Y,Hu X,Min L,Dong X,Guan Y

    更新日期:2020-03-10 00:00:00

  • Blood collection from intravenous lines: is one drawing site better than others?

    abstract:OBJECTIVE:Establish whether hemolysis in samples collected from intravenous lines is influenced by catheterization site. METHODS:Blood was collected from all patients (67 total) admitted to the emergency department the same morning, through a 20-gauge catheter placed in a vein of the upper limb directly into an evacua...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1309/lm2xcv5sqml1ontm

    authors: Lippi G,Avanzini P,Aloe R,Cervellin G

    更新日期:2014-04-01 00:00:00

  • Ficin-Treated Red Cells Help Identify Clinically Significant Alloantibodies Masked as Reactions of Undetermined Specificity in Gel Microtubes.

    abstract::Non-specific antibodies or antibodies of undetermined significance (AUS) often pose problems for a blood bank technologist and physician. It is well known that antibodies can weaken and evanesce over time, thus eluding detection by routine blood bank techniques. Special enhancement techniques exist (eg, ficin treatmen...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmw062

    authors: Hill BC,Hanna CA,Adamski J,Pham HP,Marques MB,Williams LA 3rd

    更新日期:2017-02-01 00:00:00

  • Accidental Diagnosis of Multiple Myeloma in a 44-Year-Old White Woman due to Erroneous Results via Chemical Analyzers.

    abstract:PATIENT:44-year-old white woman. CHIEF COMPLAINTS:Cramping, nausea, shortness of breath, visual disturbances ("seeing yellow dots"). MEDICAL HISTORY:Status asthmticus, tobacco use, hypertension, migraines. PRINCIPLE LABORATORY FINDINGS:TABLES 1-7, FIGURES 1-4: . ...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmv011

    authors: Bashiti O

    更新日期:2016-02-01 00:00:00

  • Schistosoma haematobium Infection That Mimics Bladder Cancer in a 66-Year-Old Ethnic Egyptian Man.

    abstract:PATIENT:66-year-old ethnic Egyptian man. CHIEF COMPLAINT:Hematuria. HISTORY OF PRESENT ILLNESS:The patient had a history of multiple episodes of gross hematuria for the past 5 years. Because the hematuria usually resolved on its own, he did not seek medical attention during that time. Bladder cancer was suspected. P...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1309/LM96EJPPBYADIOVC

    authors: Zepeda CM,Coffey KH

    更新日期:2015-10-01 00:00:00

  • Detection Rate of Colorectal Cancer or Precancer Adenoma by Colonoscopy After 1, 2, or 3 Positive Results via Fecal Immunochemical Testing.

    abstract:BACKGROUND:Single-vial fecal immunochemical testing (FIT) is an accepted method of colorectal cancer (CRC) screening. The available 3-vial FIT data set allows for comparison of colonoscopy results using various screening methods. OBJECTIVE:To determine the optimal number of vials for a strong FIT-screening program by ...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmy075

    authors: Hancock JA,Palmer GA

    更新日期:2019-07-16 00:00:00

  • The Use and Misuse of Statistical Methods in Cytopathology Studies: Review of 6 Journals.

    abstract:Background:The misuse of statistical methods in diagnostic accuracy studies has been criticized in many publications. Objective:To assess the use and misuse of statistical methods in medical journal articles. Methods:We reviewed 141 original articles from 6 cytopathology journals published in 2014. Results:In total,...

    journal_title:Laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1093/labmed/lmy036

    authors: Bahar B,Pambuccian SE,Barkan GA,Akdas Y

    更新日期:2019-01-01 00:00:00

  • Mesenchymal Stem Cells in COVID-19: A Journey from Bench to Bedside.

    abstract::The COVID-19 pandemic has led to a major setback in both the health and economic sectors across the globe. The scale of the problem is enormous because we still do not have any specific anti-SARS-CoV-2 antiviral agent or vaccine. The human immune system has never been exposed to this novel virus, so the viral interact...

    journal_title:Laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1093/labmed/lmaa049

    authors: Sahu KK,Siddiqui AD,Cerny J

    更新日期:2021-01-04 00:00:00

  • Developmental Defects Associated With DNA Copy Number Gain of Chromosome 2q33.1: A Case Report and Review of Literature.

    abstract::Caspases play a vital role during apoptosis. In addition to apoptosis, caspases play a role in cytokine gene induction and work to inhibit apoptosis. In order for individuals to thrive with useful tissue growth, the rate of cell growth and division must surpass the rate of cell division. It is well established that ex...

    journal_title:Laboratory medicine

    pub_type: 杂志文章

    doi:10.1093/labmed/lmx086

    authors: Gupta A,Yo J,Huang G,Soong L,Dong J

    更新日期:2018-03-21 00:00:00