Abstract:
PATIENT:47-year-old African American man. CHIEF COMPLAINT:Initially, serious finger abscess. The patient reported severe pain that was localized to that finger only. HISTORY OF PRESENT ILLNESS:His finger had become sore and then progressively more painful and swollen. PAST MEDICAL HISTORY:A few weeks earlier, the patient had had a similar abscess on his leg; he could not recall any specific injuries other than this. He had a past history of epilepsy that is totally unrelated to this case; he had not had any episodes in more than 10 years. Otherwise, the medical history of the patient was relatively healthy: he is a nonsmoker with no history of diabetes or steroid use. SOCIAL HISTORY:Patient washed cars for a living. FAMILY HISTORY:Noncontributory. PHYSICAL EXAMINATION:Initially, the patient was sent home with a course of antibiotics (cephalexin and trimethoprim/sulfamethoxazole) and was asked to return to the hospital for follow up within two days. By the time of the follow-up visit, the antibiotic treatment had been unsuccessful, and the patient experienced more pain in the finger; the flesh of the finger was becoming black and necrotic. The patient tested positive for all myeloid markers: myeloperoxidase (MPO), CD34, CD33, CD13, CD45, human leukocyte antigen–DR subregion (HLA-DR), CD15, and CD11c. Trilinear dysplasia was indicated by the results of bone-marrow studies and peripheral blood smear testing.
journal_name
Lab Medjournal_title
Laboratory medicineauthors
Rausch Sdoi
10.1309/LMX711TANCVDHZJJsubject
Has Abstractpub_date
2014-07-01 00:00:00pages
e96-100issue
3eissn
0007-5027issn
1943-7730pii
45/3/e96journal_volume
45pub_type
杂志文章abstract:OBJECTIVE:To investigate the expression level and clinical significance of microRNA-155 (miR-155) in bladder cancer. METHODS:We collected 102 pairs of tissue specimens from patients with primary bladder cancer and adjacent normal bladder specimens between March 2008 and May 2013. Quantitative real-time polymerase chai...
journal_title:Laboratory medicine
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Oxidative stress has been associated with the progression of atherosclerosis and activation of genes that lead to increased deposition of proteins in the extracellular matrix. Bone sialoprotein (BSP) and osteonectin are proteins involved in the initiation and progression of vascular calcification. OBJECTIVE...
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abstract:Background:Thromboelastography (TEG) has become the standard of care in liver-transplant surgery to identify real-time abnormalities in the coagulation cascade. To our knowledge, no studies have been performed to measure the intrasubject reproducibility of TEG parameters in cirrhotic patients. Objective:To perform a v...
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abstract:OBJECTIVE:To analyze the performance characteristics, stability, and clinical value of lipoprotein-associated phospholipase A2 (Lp-PLA2) using an enzymatic kinetic method. METHODS:The performance characteristics included reference intervals, precision, and accuracy. We assessed Lp-PLA2 stability by comparing Lp-PLA2 c...
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更新日期:2019-07-16 00:00:00
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abstract::Maintaining an in-compliance clinical laboratory takes continuous awareness and review of standards, regulations, and best practices. A strong quality assurance program and well informed leaders who maintain professional networks can aid in this necessary task. This article will discuss a process that laboratories can...
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更新日期:2016-05-01 00:00:00
abstract::Laboratory professionals, consultants, and treating physicians may encounter discrepancies in serological testing results for numerous reasons; identifying the reason(s) for the presence of an unexpected antibody or antigen can be challenging. A question-based approach can be useful in identifying the underlying cause...
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更新日期:2014-07-01 00:00:00
abstract::Hormographiella is a rare fungal pathogen in humans; however, case reports have described disseminated infection in immunocompromised hosts. This pathogen has been described to yield poor prognosis in patients who harbor it. Herein, we present a case report of autopsy-proven disseminated Hormographiella aspergillata i...
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更新日期:2019-10-10 00:00:00
abstract:OBJECTIVE:Examination of urine sediment is crucial in acute kidney injury (AKI). In such renal injury, tubular epithelial cells, epithelial cell casts, and dysmorphic red cells may provide clues to etiology. The aim of this study was to compare automated urinalysis findings with manual microscopic analysis in AKI. MET...
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更新日期:2020-01-02 00:00:00
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journal_title:Laboratory medicine
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更新日期:2018-07-05 00:00:00
abstract:OBJECTIVE:To explore novel biomarkers for patients with pancreatic ductal adenocarcinoma (PDAC), from the perspective of tumor hypoxia. METHODS:We screened 29 differentially expressed and hypoxia-upregulated genes from the Oncomine database. A total of 12 secretory proteins that interact with hypoxia-inducible factor ...
journal_title:Laboratory medicine
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更新日期:2020-07-08 00:00:00
abstract:OBJECTIVE:To investigate the effect of temperature and protease inhibitor on adrenocorticotrophin (ACTH) stability. METHODS:We collected blood specimens from 10 donors into K3 EDTA (ethylenediaminetetraacetic acid) and K3 EDTA + aprotinin tubes. Plasma specimens were held at room temperature and at 2 °C to 8[Formula: ...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw027
更新日期:2016-11-01 00:00:00
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journal_title:Laboratory medicine
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doi:10.1093/labmed/lmw069
更新日期:2017-08-01 00:00:00
abstract::Myeloperoxidase (MPO) deficiency, one of the most common inherited phagocyte defects, and may exist as a transient phenomenon in combination with some clinical condition. Hematological analyzer ADVIA 2120i is used to identify the different types of leukocytes based on their size and staining properties, and by mean pe...
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doi:10.1093/labmed/lmz060
更新日期:2020-03-10 00:00:00
abstract::Cording is a phenomenon in which acid fast bacilli grow in parallel and was previously used as a means of presumptive microscopic identification of Mycobacterium tuberculosis (TB). However, this process has been shown in multiple other nontuberculous mycobacterial (NTM) species. Here we present the case of an immunoco...
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doi:10.1093/labmed/lmaa082
更新日期:2020-09-21 00:00:00
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journal_title:Laboratory medicine
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doi:10.1093/labmed/lmaa104
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:The University of Maryland Medical System, like all other medical systems, is faced with providing the highest quality care in an environment of increased demands and competition for resources. Some responses to this pressure include improved integration, coordination, and efficiency. Laboratory integration ...
journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw051
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To test a hybrid polyethylene glycol (PEG)/gel method, specifically to attempt to increase reaction strength of accidentally overdiluted anti-Cob and broadly for proof of concept. METHODS:Methods were divided into 2 basic steps: sensitization and antiglobulin (AHG) testing. Sensitization was performed with P...
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doi:10.1093/labmed/lmz015
更新日期:2020-03-10 00:00:00
abstract:OBJECTIVE:Panels of clinical laboratory testing may generate "incidental" critical values from unordered parameters. Existing regulations do not clearly delineate guidelines for handling incidental critical values. The objective of this study was to examine the patterns and clinical utility of incidental critical value...
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doi:10.1093/labmed/lmw044
更新日期:2016-11-01 00:00:00
abstract:Background:When unpredicted surgical blood loss occurs, it is essential that blood arrive from the blood bank in a timely manner. Objective:To evaluate the turnaround time (TAT) for red blood cells (RBCs) from the blood bank to the operating suite. Cases with delayed TATs were further analyzed to determine potential c...
journal_title:Laboratory medicine
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doi:10.1093/labmed/lmx016
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Encephalitis is caused by infection, immune mediated diseases, or primary inflammatory diseases. Of all the causative infectious pathogens, 90% are viruses or bacteria. Granulomatous amoebic encephalitis (GAE), caused by Balamuthia mandrillaris, is a rare but life-threatening disease. Diagnosis and therapy a...
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更新日期:2020-03-10 00:00:00
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journal_title:Laboratory medicine
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更新日期:2014-04-01 00:00:00
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journal_title:Laboratory medicine
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更新日期:2017-02-01 00:00:00
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更新日期:2016-02-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LM96EJPPBYADIOVC
更新日期:2015-10-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmy075
更新日期:2019-07-16 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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更新日期:2021-01-04 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmx086
更新日期:2018-03-21 00:00:00