Abstract:
Background:Thromboelastography (TEG) has become the standard of care in liver-transplant surgery to identify real-time abnormalities in the coagulation cascade. To our knowledge, no studies have been performed to measure the intrasubject reproducibility of TEG parameters in cirrhotic patients. Objective:To perform a validation study to determine the reproducibility of TEG in cirrhosis. Methods:We recruited 30 patients with stable cirrhosis and tested 25 of them. Two blood specimens were drawn 1 hour apart; we measured the TEG parameters R time, K time, angle, maximum amplitude (MA), and functional fibrinogen (FF), along with conventional coagulation parameters. Reproducibility was assessed using the intraclass coefficient test. The TEG parameters were then compared with conventional coagulation test results. Results:The K time, angle, MA, and FF results showed excellent reproducibility (r > 0.7; P <.001). Platelets and fibrinogen correlated with MA and K time; prothrombin time (PT) and activated partial thromboplastin time (aPTT) were inversely correlated with MA. Conclusion:All parameters were reproducible when measured 1 hour apart. TEG may be suitable to investigate coagulation characteristics in patients with clinically stable cirrhosis; however, further studies are needed in patients with more advanced cirrhosis, in whomblood product use may be more prevalent.
journal_name
Lab Medjournal_title
Laboratory medicineauthors
George G,Manatasahit W,Balasubramanian M,Navarro Vdoi
10.1093/labmed/lmx041subject
Has Abstractpub_date
2018-07-05 00:00:00pages
226-230issue
3eissn
0007-5027issn
1943-7730pii
4909404journal_volume
49pub_type
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journal_title:Laboratory medicine
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journal_title:Laboratory medicine
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMAAGVXK05LUWOQN
更新日期:2014-07-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
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更新日期:2017-12-22 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMLWQDB2Q6LS7VQG
更新日期:2014-07-01 00:00:00
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journal_title:Laboratory medicine
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pub_type: 杂志文章
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更新日期:2020-05-06 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LM96EJPPBYADIOVC
更新日期:2015-10-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1093/labmed/lmw069
更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-10 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-21 00:00:00
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pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMMN1K6SBRJCGD9J
更新日期:2015-07-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
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更新日期:2019-10-10 00:00:00
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Laboratory medicine
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更新日期:2020-01-02 00:00:00
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更新日期:2020-07-08 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2018-07-05 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章,多中心研究
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更新日期:2019-01-01 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
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更新日期:2020-01-02 00:00:00
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journal_title:Laboratory medicine
pub_type: 杂志文章
doi:10.1309/LMWR9CEA2K2XVSOX
更新日期:2015-04-01 00:00:00