Abstract:
:The main clinical distinction between post-transfusion purpura (PTP) and idiopathic thrombocytopenic purpura (ITP) is the sudden development of severe thrombocytopenia in the days after transfusion. Herein, we report the case of a 53-year-old Caucasian woman who developed multiple myeloma (MM) after peripheral blood-stem-cell transplant (PBSCT), along with severe thrombocytopenia (with a nadir of 1 × 109/L); she also experienced severe adverse events after each platelet transfusion, including the first one. These reactions were absent with any other transfused blood products. The results of an human leukocyte antigen (HLA) class-1 panel reactive antibody assay were 0%, and the results of a platelet-antibody screening assay were positive for HLA class-1 antibodies and glycoprotein (Gp)IIb/IIIa antibodies. Her platelet count reached 42 × 109 per L on day 50, after rituximab on day 22 and daratumumab on day 29. Her clinical scenario was most consistent with the course of PTP.
journal_name
Lab Medjournal_title
Laboratory medicineauthors
Milito C,Masel D,Henrichs K,Schmidt AE,Kirkley S,Aljitawi O,Becker M,Blumberg N,Refaai MAdoi
10.1093/labmed/lmz004subject
Has Abstractpub_date
2019-10-10 00:00:00pages
396-400issue
4eissn
0007-5027issn
1943-7730pii
5420471journal_volume
50pub_type
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