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An Analysis of Multirules for Monitoring Assay Quality Control.

Abstract：

BACKGROUND:Multirules are often employed to monitor quality control (QC). The performance of multirules is usually determined by simulation and is difficult to predict. Previous studies have not provided computer code that would enable one to experiment with multirules. It would be helpful for analysts to have computer code to analyze rule performance. OBJECTIVE:To provide code to calculate power curves and to investigate certain properties of multirule QC. METHODS:We developed computer code in the R language to simulate multirule performance. Using simulation, we studied the incremental performance of each rule and determined the average run length and time to signal. RESULTS:We provide R code for simulating multirule performance. We also provide a Microsoft Excel spreadsheet with a tabulation of results that can be used to create power curves. We found that the R4S and 10x rules add very little power to a multirule set designed to detect shifts in the mean. CONCLUSION:QC analysts should consider using a limited-rule set.

journal_name

Lab Med

journal_title

Laboratory medicine

authors

Walker BS,Pearson LN,Schmidt RL

doi

10.1093/labmed/lmz038

subject

Has Abstract

pub_date

2020-01-02 00:00:00

pages

94-98

issue

1

eissn

0007-5027

issn

1943-7730

pii

5524575

journal_volume

51

pub_type

杂志文章

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