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A case of false-positive test results in a pregnant woman of unknown HIV status at delivery.

Abstract：

:We report a case of a false-positive HIV result in an apparently healthy pregnant woman. Since no prenatal HIV testing had been performed, we screened for HIV reactivity utilizing the Architect HIV-Ag/Ab Combo assay. Results obtained were inconsistent in that they were repeatedly HIV reactive on a single serum sample while nonreactive on a plasma sample. However, both sample types were nonreactive on the Advia Centaur HIV-1/O/2 and Oraquick assays. For further confirmation, an HIV-1 Western blot and viral load were performed; blot results were indeterminate while the viral load was undetectable. We concluded that the repeatedly reactive serum serology results were false-positive. While the cause of this false reactivity is not clear, most likely fibrin microclots in the serum sample interfered with the assay and thus accounted for the false positivity. Plasma may thus provide a more appropriate sample type when using the Architect assay, especially when testing pregnant women.

journal_name

Lab Med

journal_title

Laboratory medicine

authors

Akl P,Blick KE

doi

10.1309/LMAAGVXK05LUWOQN

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

259-63

issue

3

eissn

0007-5027

issn

1943-7730

pii

45/3/259

journal_volume

45

pub_type

杂志文章

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