Abstract:
OBJECTIVE:To establish a new indicator derived from reticulocyte hemoglobin (Ret-He) content and red blood cell (RBC) indices for screening for iron deficiency anemia (IDA) in an area in whch thalassemia is prevalent. METHODS:Blood specimens from 304 women aged between 18 and 30 years residing in northeast Thailand were collected and measured for RBC and reticulocyte parameters. Iron deficiency was diagnosed when a participant had a serum ferritin level of less than 15 ng per mL. Thalassemia genotypes were defined by hemoglobin (Hb) and DNA analyses. RESULTS:Of the total participants, 25% had iron deficiency (ID) and 50% carried the thalassemia gene. Various mathematical formulas were established and analyzed using the receiver operating characteristic (ROC) curve. The formula derived from Ret-He: (Ret-He/RDW-SD) × 10, was the best predictor for identifying ID among participants (area under the curve [AUC] = 0.812). Further testing of this indicator among individuals with positive thalassemia-screening results revealed stronger performance with an AUC of 0.874. CONCLUSIONS:The findings indicate that the formula derived from Ret-He might be applicable for screening ID in areas in which thalassemia is prevalent.
journal_name
Lab Medjournal_title
Laboratory medicineauthors
Jamnok J,Sanchaisuriya K,Chaitriphop C,Sanchaisuriya P,Fucharoen G,Fucharoen Sdoi
10.1093/labmed/lmz099subject
Has Abstractpub_date
2020-09-01 00:00:00pages
498-506issue
5eissn
0007-5027issn
1943-7730pii
5735226journal_volume
51pub_type
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更新日期:2017-11-08 00:00:00
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