Abstract:
:Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Miloradović Z,Mihailović-Stanojević N,Jovović Đ,Ivanov M,Vajić UJ,Karanović D,Grujić Milanović Jdoi
10.4149/gpb_2014033subject
Has Abstractpub_date
2015-01-01 00:00:00pages
89-94issue
1eissn
0231-5882issn
1338-4325journal_volume
34pub_type
杂志文章abstract::Using spin-labeled fatty acid derivatives and maleimide, the effect of temperature on the structural state of various parts of the lipid bilayer of sarcoplasmic reticulum (SR) membranes and the segmental motion of the Ca-ATPase molecule were investigated. The mobility of the spin probes localized in the hydrophobic zo...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::Electron spin resonance spectroscopy (ESR) was used to study the effects of amphiphilic amines of the carbamate, amide, and ester type and amine oxide on the photosynthetic system of spinach chloroplasts. The ESR signal II connected to the photosynthetic center PS II donor side was observed to diminish in the presence...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Inhibition of angiogenesis involves blocking of tyrosine kinases (TK) implicated in signalling of vascular endothelial growth factor receptors (VEFGR). The inhibition of TK results in a disruption of Ras/Raf/MEK/ERK1/2 and PI3K/Akt signalling pathways. We evaluated recently developed TK inhibitor 22SYM and compared it...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2015055
更新日期:2016-10-01 00:00:00
abstract::Depression is a brain disorder characterized by severe emotional, cognitive, neuroendocrine and somatic dysfunction. Although the latest generation of antidepressant drugs has improved clinical efficacy and safety, the onset of their clinical effect is significantly delayed after treatment commencement, and a large nu...
journal_title:General physiology and biophysics
pub_type: 杂志文章,评审
doi:10.4149/gpb_2015013
更新日期:2015-10-01 00:00:00
abstract::The effect of binding of an antitumour drug cis-diamminedichloroplatinum(II) (cis-[Pt(NH3)2Cl2]) to DNA on cutting effectiveness of BamHI, EcoRI, and SalI restriction endonucleases was quantitatively determined. The platinum complex inhibits the cleavage of plasmid pHC624 DNA linearized by BglI restrictase. From the p...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::The hyperpolarisation of the membrane potential in Characeae above that of the diffusion potential is explained by the operation of the electrogenic proton pump. We studied the interaction of calcium with the functioning of the pump. The membrane potential was measured using the standard microelectrode technique. An i...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::This study investigated time-dependent variations in the activities of adenosine deaminase (ADA), an adenosine-metabolizing enzyme, and myeloperoxidase (MPO), an oxidation reaction-catalyzing enzyme, in control and streptozotocin (STZ)-induced diabetic rat liver. The animals were sacrificed at six different times of d...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::125I-labelled o-iodobenzoate (OIB) was prepared by means of an isotopic exchange reaction; its distribution and excretion were determined and its pharmacokinetic parameters in rats were calculated. The calculated value of the half-life of OIB elimination was 38.7 +/- 0.7 min, the distribution volume was 278.2 +/- 53.5...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::A patient with a strongly lesioned spinal cord, sub C5, relearned running, besides improving other movements, by an oscillator formation training (rhythmic, dynamic, stereotyped exercise). After 45 days of jumping on a springboard and other rhythm trainings, the patient was able to run 90 m in 41 s (7.9 km/h) (even 9....
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::The substantia gelatinosa of the trigeminal subnucleus caudalis has been considered to be an essential location for the transference of orofacial sensory signals. The co-localization of inhibitory and excitatory neurotransmitters in the same substantia gelatinosa (SG) neurons has demonstrated their essential part in t...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2019027
更新日期:2019-09-01 00:00:00
abstract::Beat-to-beat variability of action potential duration (short-term variability, SV) is an intrinsic property of mammalian myocardium. Since the majority of agents and interventions affecting SV may modify also action potential duration (APD), we propose here the concept of relative SV (RSV), where changes in SV are nor...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2015019
更新日期:2016-01-01 00:00:00
abstract::Currents through DPI 201-106 modified single cardiac sodium channels in guinea pig ventricular cells were measured using the patch clamp technique in the cell-free configuration to control the sodium concentrations on both sides of the patch membrane. Current-voltage relationships of the single channels were obtained ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::The aim of this paper was to study the protein remodelling of the left ventricle following repeated administration of either daunorubicin (DNR) or DNR in combination with the cardioprotective agent dexrazoxane (DXZ). The experiment was carried out on three groups of Chinchilla male rabbits: 1. DNR (3 mg/kg i.v.), 2. D...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Although numerous studies have shown the existence of various types of ion conductance in antral part of gastric fundus mucosa epithelia of amphibian, practically no data are available on ion conductance in higher animal species. Present experiments were undertaken to check the possible existence of ion conductance in...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::The fibroblast growth factor receptors (FGFRs) and Ras/mitogen activated protein (RAS/MAP) signalling cascades are the main molecular pathways involved in breast carcinogenesis. This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphism...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2017033
更新日期:2017-12-01 00:00:00
abstract::The aim of this study was to assess whether an endothelin-A receptor (ETA-R) blocker, BQ123, or an endothelin-B (ETB-R) receptor blocker, BQ788, influences nuclear factor kappa beta (NF-κB) pathway, free radical generation, tumor necrosis factor-alpha (TNF-α) concentration, and glutathione redox system in hearts obtai...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2012_031
更新日期:2012-09-01 00:00:00
abstract::Aiming at making the Münch model more adequate to the biological reality we introduce certain modifications and complements. Considering the model within the framework of so-called integrated system of long-distance water transport in plants we present a quantitative analysis based on the Kedem-Katchalsky formalism. A...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::The effect of K+ and Na+ on the properties of DNA aptamers that selective binds to fibrinogen (FIBRI) and heparin (HEPA) exosites of human alpha-thrombin was studied by circular dichroism (CD). The complexes of FIBRI-K+ were slightly more stable than HEPA-K+. However, lower stability was observed for HEPA-K+ at presen...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Arterial base deficit/excess (BD/E) is commonly used marker of metabolic acidosis in critically ill patients, but requires an arterial puncture and blood gas analysis. We hypothesized that serum bicarbonate (HCO3), which can be routinely obtained, strongly correlates with arterial BD/E and provides equivalent predicti...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Homeostasis and development in vertebrates are regulated by cell proliferation, differentiation and death. Permeability of mitochondrial membranes, a decisive feature of apoptosis, is regulated by Bcl-2 family regulators. Protein p53 is able to reduce bcl-2 and promote bax expression. This study focused on the immunoh...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract::The dynamics of a bioreactor with a variable volume and an active solute flux based on the thermodynamics of irreversible processes and stability analysis was studied. The active solute flux may control both the bioreactor volume and the hydrostatic pressure as well as the concentration of the solute inside the cell i...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract::Sleep is considered as a physiological regulator in the body. Gamma-aminobutyric acid (GABA) is a neurotransmitter that modulates sleep and affects cardiac functions. We evaluated effects of acute sleep deprivation (SD) on cardiac hemodynamic parameters, expression of pro-inflammatory cytokines, and Heat shock protein...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2017049
更新日期:2018-05-01 00:00:00
abstract::Phosphorylation of P-glycoprotein (PGP) by some protein kinases may play an important role in the regulation of its drug transport activity, and may also be important for the development of multidrug resistance (MDR) phenotype. In the present study we investigated the expression of three groups of mitogen-activated pr...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::This study was designed to investigate the possible effectiveness of chronic resveratrol administration on redox state, inflammatory mediators and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n = 6): normal control, diabetic control, normal rats treated with resveratrol, and diabeti...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2012_039
更新日期:2012-12-01 00:00:00
abstract::Homocysteine (Hcys) may be implicated in different diseases, especially in cardiovascular illnesses. The most reactive form of Hcys is its cyclic thioester-homocysteine thiolactone (HTL), which is formed in plasma and represents up to 0.29% of plasma total Hcys. Recently, it has been observed that Hcys and HTL may mod...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2010_02_186
更新日期:2010-06-01 00:00:00
abstract::The existence of a high-conductance voltage sensitive chloride channel in BC3H1 myoblasts is documented. The conductance of the channel in symmetrical 150 mmol/l sodium chloride is around 400 pS. The probability of the channel being in the open state decreases with increasing of the imposed voltage from holding potent...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2019019
更新日期:2019-07-01 00:00:00
abstract::In the present study, we evaluated the antioxidant potential of Artemisia campestris essential oil (ACEO) and the possible protective effects against deltamethrin induced hepatic toxic effects. The ACEO showed radical scavenging activity with IC50 = 47.66 ± 2.51 µg/ml, ferric reducing antioxidant power (FRAP) potentia...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2016057
更新日期:2017-07-01 00:00:00
abstract::The aim of the present work was to test the sensitivity of young male Wistar rats, Dobrá Voda (Dv:WI) to the diabetogenic effect of streptozotocin (STZ) with regard to their health condition and mortality rates. Eight-week-old rats, weighing from 200 to 230 g, were randomised into five groups of eight animals. Strepto...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::The hydrolytic activity and interaction of acidic and neutral phospholipase A2 (PLA2) with large unilamellar liposomes treated with cobra venom cytotoxin Vc5 (CT Vc5) were studied to more fully understand the modulating effects of cationic membrane-active peptides on PLA2. Studies were done by fluorescence displacemen...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00