Abstract:
:125I-labelled o-iodobenzoate (OIB) was prepared by means of an isotopic exchange reaction; its distribution and excretion were determined and its pharmacokinetic parameters in rats were calculated. The calculated value of the half-life of OIB elimination was 38.7 +/- 0.7 min, the distribution volume was 278.2 +/- 53.5 ml . kg-1. The rate of elimination activity in urine was in agreement with the above values. On the basis of the developed technique of separation of OIB metabolites by thin-layer chromatography, their relative proportion in rat urine was determined; within 24 h 50% of the eliminated activity was in the original form (as OIB) and the metabolites of o-iodohippurate and o-iodobenzoylglucuronide formed approximately 25% of the activity eliminated in urine each.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Láznícek M,Kvĕtina J,Srámek B,Kronrád L,Hradílek Psubject
Has Abstractpub_date
1983-08-01 00:00:00pages
279-85issue
4eissn
0231-5882issn
1338-4325journal_volume
2pub_type
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