Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats.

Abstract:

:This study was designed to investigate the possible effectiveness of chronic resveratrol administration on redox state, inflammatory mediators and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n = 6): normal control, diabetic control, normal rats treated with resveratrol, and diabetic rats treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; i.p.), 15 min after the prescription of nicotinamide (110 mg/kg; i.p.) in 12 h-fasted rats. Four-month oral resveratrol administration (5 mg/kg/day) significantly alleviated hyperglycemia, weight loss, enhancement of oxidative markers (lipid peroxidation index, nitrite/nitrate content and oxidized to reduced glutathione ratio) and superoxide dismutase activity in diabetic rats. Moreover, resveratrol administration to diabetic rats improved the elevated levels of plasma TNFα and IL-6 as well as NF-κB activity of polymorphonuclear cells. On the other hand, four months resveratrol administration decreased the apoptosis rate in the kidney, heart, retina, sciatic nerve and the polymorphonuclear cells of diabetic rats. These beneficial antidiabetic observations suggest that treatment with resveratrol may be considered as a therapeutic approach to reduce diabetic-related complications.

journal_name

Gen Physiol Biophys

authors

Soufi FG,Vardyani M,Sheervalilou R,Mohammadi M,Somi MH

doi

10.4149/gpb_2012_039

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

431-8

issue

4

eissn

0231-5882

issn

1338-4325

journal_volume

31

pub_type

杂志文章
  • Lidocaine alters the input resistance and evokes neural activity in crayfish sensory neurons.

    abstract::Lidocaine, a use-dependent Na(+) channel blocker, paradoxically evokes neural activation in the slowly adapting stretch receptor organ of crayfish at 5-10 mmol/l concentration. For elucidating the underlying mechanisms of this paradoxical effect, a series of conventional electrophysiological experiments were performed...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Keceli MB,Purali N

    更新日期:2007-03-01 00:00:00

  • Cross-reacting material 197 (CRM197) affects actin cytoskeleton of endothelial cells.

    abstract::CRM197, cross-reacting material 197, is a mutant of diphtheria toxin (DTx). CRM197 is used in pharmacology as a carrier protein. It has been recently shown that CRM197 causes breakdown in actin filaments. In order to show intracellular localization of CRM197 and visualize cell structure via actin cytoskeleton, endothe...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2017006

    authors: Özerman Edis B,Varol B,Hacıosmanoğlu E,Ünlü A,Bektaş M

    更新日期:2017-10-01 00:00:00

  • Modulation of inhibitory and excitatory neurotransmissions by Zn2+ on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.

    abstract::The substantia gelatinosa of the trigeminal subnucleus caudalis has been considered to be an essential location for the transference of orofacial sensory signals. The co-localization of inhibitory and excitatory neurotransmitters in the same substantia gelatinosa (SG) neurons has demonstrated their essential part in t...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2019027

    authors: Nguyen HT,Jang SH,Park SJ,Cho DH,Han SK

    更新日期:2019-09-01 00:00:00

  • A circular dichroism study of the stability of guanine quadruplexes of thrombin DNA aptamers at presence of K+ and Na+ ions.

    abstract::The effect of K+ and Na+ on the properties of DNA aptamers that selective binds to fibrinogen (FIBRI) and heparin (HEPA) exosites of human alpha-thrombin was studied by circular dichroism (CD). The complexes of FIBRI-K+ were slightly more stable than HEPA-K+. However, lower stability was observed for HEPA-K+ at presen...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Poniková S,Antalík M,Hianik T

    更新日期:2008-12-01 00:00:00

  • Effect of 2.45 GHz microwave radiation on the fertility pattern in male mice.

    abstract::A number of studies have reported that male reproductive organs are susceptible to electromagnetic fields (EMFs). The aim of this study was to explore the effects of microwave radiation exposures on 6-8 weeks old male Swiss albino mice. Mice were divided into two groups: group I - sham-exposed (Control), and group II ...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2017059

    authors: Jonwal C,Sisodia R,Saxena VK,Kesari KK

    更新日期:2018-07-01 00:00:00

  • Phospholipase A2 and cobra venom cytotoxin Vc5 interactions and membrane structure.

    abstract::The hydrolytic activity and interaction of acidic and neutral phospholipase A2 (PLA2) with large unilamellar liposomes treated with cobra venom cytotoxin Vc5 (CT Vc5) were studied to more fully understand the modulating effects of cationic membrane-active peptides on PLA2. Studies were done by fluorescence displacemen...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Gasanov SE,Gasanov NE,Rael ED

    更新日期:1995-04-01 00:00:00

  • Silencing of long non-coding RNA PCAT6 restrains gastric cancer cell proliferation and epithelial-mesenchymal transition by targeting microRNA-15a.

    abstract::Gastric cancer (GC) is a high mortality disease. We studied the function and mechanism of long non-coding RNA prostate cancer-associated transcript 6 (lncRNA PCAT6) on cell proliferation and epithelial-mesenchymal transition (EMT) in GC cells. CCK-8, flow cytometry and colony formation assay were respectively used to ...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2019044

    authors: Dong D,Lun Y,Sun B,Sun H,Wang Q,Yuan G,Quan J

    更新日期:2020-01-01 00:00:00

  • Quercetin and epigallocatechin gallate effects on the cell membranes biophysical properties correlate with their antioxidant potential.

    abstract::Quercetin and epigallocatechin gallate are two of the most abundant polyphenols in dietary plants, including apples, onions, red wine and green tea. The bioactivity of polyphenols is linked to their ability to interact with cell membranes without being internalized. The aim of the present study was to assess the short...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2012_005

    authors: Margina D,Ilie M,Manda G,Neagoe I,Mocanu M,Ionescu D,Gradinaru D,Ganea C

    更新日期:2012-03-01 00:00:00

  • Ion compartmentalization in frog oocytes as demonstrated by X-ray microanalysis.

    abstract::The distributions of K, Na, Mg and Ca within frog ovarian and oviductal oocytes were studied by electron probe wavelength dispersive X-ray microanalysis. An important heterogeneity could be found both in nuclear and jelly coated oocytes. The highest K, Mg and, to a lesser extent, Na concentrations were found in the pi...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Burovina IV,Pivovarova NB,Pogorelov AG

    更新日期:1985-06-01 00:00:00

  • Molecular crowding has no effect on the dilution thermodynamics of the biologically relevant cation mixtures.

    abstract::The ionic composition of intracellular space is rigorously maintained in the expense of high-energy expenditure. It has been recently postulated that the cytoplasmic ionic composition is optimized so the energy cost of the fluctuations of calcium ion concentration is minimized. Specifically, thermodynamic arguments ha...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2016029

    authors: Głogocka D,Przybyło M,Langner M

    更新日期:2017-04-01 00:00:00

  • Electromyographic identification of spinal oscillator patterns and recouplings in a patient with incomplete spinal cord lesion: oscillator formation training as a method to improve motor activities.

    abstract::A patient with a strongly lesioned spinal cord, sub C5, relearned running, besides improving other movements, by an oscillator formation training (rhythmic, dynamic, stereotyped exercise). After 45 days of jumping on a springboard and other rhythm trainings, the patient was able to run 90 m in 41 s (7.9 km/h) (even 9....

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Schalow G,Blanc Y,Jeltsch W,Zäch GA

    更新日期:1996-08-01 00:00:00

  • Malate dehydrogenases--structure and function.

    abstract::Malate dehydrogenases (MDH, L-malate:NAD oxidoreductase, EC 1.1.1.37), catalyze the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in the malate/aspartate shuttle across the mitochondrial membrane, and in the tricarboxylic acid cycle within the mitochondria...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章,评审

    doi:

    authors: Minárik P,Tomásková N,Kollárová M,Antalík M

    更新日期:2002-09-01 00:00:00

  • Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring.

    abstract::The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant a...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2012_019

    authors: Riljak V,Maresova D,Jandova K,Bortelova J,Pokorny J

    更新日期:2012-06-01 00:00:00

  • Electric-field-induced fusion of enzyme-treated human red cells: kinetics of intermembrane protein exchange.

    abstract::Fusion of neuraminidase or trypsin pretreated human erythrocytes and untreated cells was performed. The obtained doublets had a permanent dipole moment which disappeared as a function of time. Since the dipole moment disappearance is due to protein interdiffusion the lateral diffusion constant may be determined. This ...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Donath E,Arndt R

    更新日期:1984-06-01 00:00:00

  • Energy and glucose pathways in thiamine deficient primary rat brain microvascular endothelial cells.

    abstract::Thiamine deficiency (TD) results in lactate acidosis, which is associated with neurodegeneration. The aim of this study was to investigate this alteration in primary rat brain endothelia. Spectrophotometric analysis of culture media revealed that only a higher concentration of pyrithiamine, which accelerates the intra...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Ham D,Karska-Wysocki B

    更新日期:2005-12-01 00:00:00

  • Role of glucagon-like peptide-1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts.

    abstract::Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from intestinal L cells upon nutrients ingestion, and is currently used for treating diabetes mellitus. It plays an important role in receptor modulation and cross talk with insulin at the coronary endothelium (CE) and cardiomyocytes (CM) in diabetic type...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2011_01_34

    authors: Barakat GM,Nuwayri-Salti N,Kadi LN,Bitar KM,Al-Jaroudi WA,Bikhazi AB

    更新日期:2011-03-01 00:00:00

  • Substates of cardiac sodium channels are due to both decrease in conductance and changes in selectivity.

    abstract::Currents through DPI 201-106 modified single cardiac sodium channels in guinea pig ventricular cells were measured using the patch clamp technique in the cell-free configuration to control the sodium concentrations on both sides of the patch membrane. Current-voltage relationships of the single channels were obtained ...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Albitz R,Drogmans G,Nilius B

    更新日期:1991-02-01 00:00:00

  • Effect of melatonin on the isolated heart in the standard perfusion conditions and in the conditions of calcium paradox.

    abstract:UNLABELLED:The effect of melatonin (MLT) on the isolated rat heart was studied using the standard perfusion conditions (Langendorff preparation) and model of calcium paradox (Ca(2+)-paradox). Ca(2+)-paradox was induced by 1 minute perfusion with Ca(2+)-free Krebs-Henseleit (KH) solution and subsequent 20 minutes perfus...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Vazan R,Styk J,Béder I,Pancza D

    更新日期:2003-03-01 00:00:00

  • Ischemia-reperfusion injury--antiarrhythmic effect of melatonin associated with reduced recovering of contractility.

    abstract::The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart. 25 min global ischemia was induced and followed by 30 min of reperfusion. Melatonin (10 micromol/l) was present in the perfusion solution during the whole experiment. Experiment revealed p...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Vazan R,Pancza D,Béder I,Styk J

    更新日期:2005-09-01 00:00:00

  • Alamethicin-induced pore formation in biological membranes.

    abstract::The effects of alamethicin on the membrane barrier function of rabbit erythrocytes, human platelets and sarcoplasmic reticulum vesicles, as well as on that of brain microsomes and liver mitochondria of the rat were compared. An upset of the barrier function was observed for plasma membranes of brain microsomes as well...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Ritov VB,Tverdislova IL,Avakyan TYu,Menshikova EV,Leikin YuN,Bratkovskaya LB,Shimon RG

    更新日期:1992-02-01 00:00:00

  • Delayed fluorescence induction transients: mathematical modelling based on the chosen kinetic models.

    abstract::The paper deals with mathematical modelling of the transients obtained by fitting of delayed fluorescence (DF) induction trace. The transients are in certain, doubtless connection with electrochemical gradient (ECG) formed across thylakoid membranes upon illumination. The fitting of the C and D transients by using con...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Marković DZ,Kalauzi A,Radenović CN

    更新日期:2001-09-01 00:00:00

  • The role of the apoptosis and the genes regulating apoptosis in the early differentiation of human embryo.

    abstract::Apoptosis (programmed cell death) is an important process participating in the formation of organs and tissues during embryogenesis. Our aim of the work is studying the role of the apoptosis during the human embryonic differentiation. We tend to give acquired findings into the correlation with expression of proteins B...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Lichnovský V,Procházková J,Erdösová B,Nepozitková D,Kolár Z

    更新日期:1999-12-01 00:00:00

  • Early detection of myocardial viability by hyperbaric oxygenation in patients with acute myocardial infarction treated with thrombolysis.

    abstract::Hyperbaric oxygen treatment (HBO) could transiently reverse hypoxia during acute myocardial infarction (AMI). In order to evaluate whether early HBO can identify viable segments after AMI, improvement of wall motion score index (WMSI) after HBO was compared to dobutamine stress echocardiography (DSE). Thirty-one patie...

    journal_title:General physiology and biophysics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Dekleva M,Ostojic M,Neskovic A,Mazic S,Vlahovic A,Suzic Lazic J,Dekleva N

    更新日期:2009-01-01 00:00:00

  • Structural changes of liposome phospholipid packing induced by cytotoxin of the Central Asia cobra venom.

    abstract::Liposomes and proteoliposomes obtained from rat brain were used; structural changes induced by Vc5 cytotoxin (CT) from Central Asia cobra venom have been studied by the EPR method using spin probes (5-, 10-, or 12-doxylstearic acid). The addition of CT to liposome samples, containing spin probes resulted in the appear...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Aripov TF,Salakhutdinov BA,Salikhova ZT,Sadykov AS,Tashmukhamedov BA

    更新日期:1984-12-01 00:00:00

  • Effects of nordihydroguaiaretic acid on the chemiluminescence of murine phagocytes.

    abstract::Antioxidative effects of nordihydroguaiaretic acid (NDGA) on murine bone marrow phagocytes were studied using luminol- and lucigenin-amplified chemiluminescence (CL). NDGA applied in vitro strongly suppressed the opsonized zymosan particles stimulated CL response in a dose-dependent manner (in concentrations of 0.3-30...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Lojek A,Kozubík A,Cíz M,Hofmanová J

    更新日期:1993-08-01 00:00:00

  • Thermodynamic analysis of rat brain opioid mu-receptor-ligand interaction.

    abstract::Opioid mu-receptors are membrane bound receptors. The mechanism by which they transduce their biological effect into the inner compartment of the postsynaptic cell is still not fully understood. The present study was attempted to the measurement of changes of the thermodynamic parameters of the receptor--agonist/antag...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Zeman P,Tóth G,Kvetnanský R

    更新日期:1987-06-01 00:00:00

  • Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment.

    abstract::Hyperglycaemia-induced oxidative stress makes an important contribution to the aetiology of diabetic neuropathy. The aim of our study was to evaluate the effect of the antioxidant stobadine (STB) in comparison with a treatment by a high-dose of alpha-lipoic acid (ALA), on the neurological consequences of chronic hyper...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Skalská S,Kucera P,Goldenberg Z,Stefek M,Kyselová Z,Jariabka P,Gajdosíková A,Klobucníková K,Traubner P,Stolc S

    更新日期:2010-03-01 00:00:00

  • Synergistic effect of vitamin C on DNA damage induced by cadmium.

    abstract::Salts of divalent cadmium are well-known human mutagens and carcinogens. In the present work, the ability of vitamin C to modulate genotoxic effects of cadmium chloride on human lymphocytes was assessed using single cell gel electrophoresis (comet assay). Vitamin C at 20 and 100 micromol/l and cadmium at 5, 30 and 150...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:

    authors: Błasiak J,Trzeciak A,Dziki A,Ulańska J,Pander B

    更新日期:2000-12-01 00:00:00

  • Heart ventricles specific stress-induced changes in β-adrenoceptors and muscarinic receptors.

    abstract::The left and right ventricles fulfill different role in heart function. Here we compare chamber specific changes in local catecholamine concentrations; gene expression and the receptor protein amount of all three β-adrenoceptors (β-AR) in rat right heart ventricles exposed to acute (1 session) and repeated (7 sessions...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2014002

    authors: Tillinger A,Novakova M,Krizanova O,Kvetnansky R,Myslivecek J

    更新日期:2014-01-01 00:00:00

  • Chromosome damage in human cells induced by UMTS mobile telephony radiation.

    abstract::Environmental exposure to modern microwave telecommunication electromagnetic fields (EMFs) has increased to unprecedented levels with consequent health complaints and concerns. Many studies have already reported genotoxic effects on a variety of organisms and cell/tissue types. Human peripheral blood lymphocytes from ...

    journal_title:General physiology and biophysics

    pub_type: 杂志文章

    doi:10.4149/gpb_2019032

    authors: Panagopoulos DJ

    更新日期:2019-09-01 00:00:00