Post-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus.

Abstract:

:The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 (FGF-2) or its downstream mediator endothelial nitric oxide synthase (eNOS) was unchanged. Other signaling pathways appear to be involved in isolation-induced reduction in VEGF gene expression. Sex differences in VEGF and eNOS gene expression with significantly higher mRNA levels in females than males were revealed.

journal_name

Gen Physiol Biophys

authors

Chmelova M,Jezova D,Riecansky I,Hlavacova N

doi

10.4149/gpb_2019019

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

365-368

issue

4

eissn

0231-5882

issn

1338-4325

journal_volume

38

pub_type

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