Abstract:
:The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 (FGF-2) or its downstream mediator endothelial nitric oxide synthase (eNOS) was unchanged. Other signaling pathways appear to be involved in isolation-induced reduction in VEGF gene expression. Sex differences in VEGF and eNOS gene expression with significantly higher mRNA levels in females than males were revealed.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Chmelova M,Jezova D,Riecansky I,Hlavacova Ndoi
10.4149/gpb_2019019subject
Has Abstractpub_date
2019-07-01 00:00:00pages
365-368issue
4eissn
0231-5882issn
1338-4325journal_volume
38pub_type
杂志文章abstract::Participation of electrostatic and other noncovalent interactions in the binding of tricyclic antidepressants (TCAs) to the lipid bilayers was estimated from pH-dependencies of imipramine, desipramine, amitriptyline and nortriptyline binding to the lipid bilayers prepared from different phospholipids, both electroneut...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::The postnatal development of high-affinity 3H-muscimol binding to GABAA receptors was studied in the lateral geniculate nucleus, superior colliculus, frontal and visual cortex of the rat brain. In the lateral geniculate nucleus 3H-muscimol binding rises from day 10 through day 37 reaching the highest value during the ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA). Auxiliary subunits of the HVA calcium channels contribute significantly to biophysical properties of the channels. We have cloned and characterized mem...
journal_title:General physiology and biophysics
pub_type: 杂志文章,评审
doi:
更新日期:2005-06-01 00:00:00
abstract::The passive mechanical properties of whole muscle in active and nonactive states are compared. The experimental results are presented as stress-strain curves, which are analyzed in the framework of the current theoretical background [viz. the freely-jointed chain model (FJCM) and the worm-like chain model (WLCM)] in a...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::The inhibition of sodium and potassium currents in frog myelinated fibres by ajmaline (AM) and its quaternary derivative, N-propyl ajmaline (NPA), depends on voltage-clamp pulses and the state of channel gating mechanisms. The permanently charged NPA and protonated AM interact only (or mainly) with open channels, whil...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::The postnatal developmental changes in mitochondrial uncoupling protein 1 (UCP 1) and F1-ATP synthase (ATPase) subunit levels in the interscapular brown adipose tissue (BAT) were studied in golden Syrian hamsters (Mesocricetus auratus) using electron microscopy in situ immunocytochemistry. The relatively low initial d...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Calcium ions mediate extracellular signals on intracellular processes. The signalling system based on transient rises or oscillations of the cytoplasmic calcium concentration has potential advantages. The relevant mechanisms of intracellular concentration changes include calcium-induced calcium release and calcium dep...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::Hyperlipidemia is found to be associated with changes in fatty acid (FA) profiles. The aim of this study was to investigate the effects of AHA-Step-1 dietary treatment and combination of fibrates (gemfibrozil) with dietary intervention on serum and erythrocyte phospholipid FA composition in human hyperlipidemia. 78 st...
journal_title:General physiology and biophysics
pub_type: 临床试验,杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Binding of the tricyclic antidepressant imipramine (IMI) to neutral and negatively charged lipid membranes was investigated using a radioligand binding assay combined with centrifugation or filtration. Lipid bilayers were composed of brain phosphatidylcholine (PC) and phosphatidylserine (PS). IMI binding isotherms wer...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::The voltage dependent ionic currents in cultured embryonic skeletal myocytes at stages of development ranging from 1 to 6 day were studied using the whole-cell patch clamp technique. Sodium (INa) and calcium (ICa) inward and potassium (IK) outward currents were observed at all stages. INa did not differ from that desc...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::Kinase-targeted therapy is a new and promising approach to disease treatment. However, some kinase inhibitors have been observed to cause an off-target adverse risk for skeletal system by influencing the growth of osteoblasts. It is known that the proliferation and differentiation of osteoblasts are essentially regula...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2018030
更新日期:2019-01-01 00:00:00
abstract::Phosphorylation of P-glycoprotein (PGP) by some protein kinases may play an important role in the regulation of its drug transport activity, and may also be important for the development of multidrug resistance (MDR) phenotype. In the present study we investigated the expression of three groups of mitogen-activated pr...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::Ischemic and reperfusion injury is a serious condition related to numerous biochemical and electrical abnormalities of the myocardium. It has been repeatedly studied in various animal models. In this study, the production of hydroxyl radicals and electrophysiological parameters were compared in three species. Rat, gui...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2013016
更新日期:2013-06-01 00:00:00
abstract::Thermal inactivation of peroxidase (POD) in an extract of Picea omorika (Pancić) Purkyne needles initiated by heat treatment was studied. This is the first study of this kind on a conifer species. Non-linear regression analysis was applied on the inactivation rate data, combining Mitscherlich and Arrhenius equations, ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2009_01_78
更新日期:2009-03-01 00:00:00
abstract::Charcot-Marie-Tooth disease (CMT) and related peripheral neuropathies are the most commonly inherited neurological disorders in humans, characterized by clinical and genetic heterogeneity. The most prevalent clinical entities belonging to this group of disorders are CMT type 1A (CMT1A) and hereditary neuropathy with l...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2011_04_379
更新日期:2011-12-01 00:00:00
abstract::Changes in the Young elasticity modulus in perpendicular direction to the membrane surface E perpendicular, in the coefficient of dynamic viscosity eta, in the electric capacitance C, in the surface charge U1, in the conductivity g and in the coefficient of non-linearity beta of current-voltage characteristic caused b...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
abstract::Gastric cancer (GC) is a high mortality disease. We studied the function and mechanism of long non-coding RNA prostate cancer-associated transcript 6 (lncRNA PCAT6) on cell proliferation and epithelial-mesenchymal transition (EMT) in GC cells. CCK-8, flow cytometry and colony formation assay were respectively used to ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2019044
更新日期:2020-01-01 00:00:00
abstract::The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to be involved in regulating the levels of inflammatory markers and apoptosis in macrophages. This study aims to investigate the function and regulation of PCSK9 in myocardial ischaemia. The results of our study showed dramatically ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb-2019057
更新日期:2020-03-01 00:00:00
abstract::A model for the dynamics of quasi-1D lipid structures in biological membranes is proposed. The model takes into account interactions between the lipid heads and hydro-carbon chains, the description of their relaxation dynamics being based on the phenomenological Ginzburg-Landau approach. It is shown that in lateral li...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::The effect of hydroxyl radicals generated by the FeSO4/H2O2 system on structural properties of proteins and membranes was studied in rat cardiac mitochondria and myofibrils. Exposure of mitochondria to 0.1 mmol/l FeSO4/EDTA plus 1 mmol/l H202 at 37 degrees C for 30 or 60 min caused conjugated diene formation, but it w...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::Icaritin, a prenylflavonoid derivative from Epimedium Genus, has been reported to exhibit tumor inhibitory effects on many types of tumor cells. Numerous studies have demonstrated that microRNAs (miRs) involve in the biological process of carcinogenesis by controlling expression of their target mRNAs to facilitate tum...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2019041
更新日期:2019-11-01 00:00:00
abstract::Semiserial sections of lung capillaries of seven rabbits were examined for megakaryocytes. Triads of serial sections of each lobe were examined, and megakaryocyte counts per cm2 were determined. Median megakaryocyte count was determined for each lobe. The lobal values were used to calculate the was determined for each...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract::The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2013070
更新日期:2014-01-01 00:00:00
abstract::Aiming at making the Münch model more adequate to the biological reality we introduce certain modifications and complements. Considering the model within the framework of so-called integrated system of long-distance water transport in plants we present a quantitative analysis based on the Kedem-Katchalsky formalism. A...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::The interactions between haematoporphyrin (HP) and bilayer lipid membranes (BLM) were studied. A weak effect of HP on BLM conductivity was observed at HP concentrations ranging between 10(-6) and 3 x 10(-5) mol/l. Modulus of elasticity in the direction normal to the membrane plane (E perpendicular) and dynamic viscosi...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::Environmental exposure to modern microwave telecommunication electromagnetic fields (EMFs) has increased to unprecedented levels with consequent health complaints and concerns. Many studies have already reported genotoxic effects on a variety of organisms and cell/tissue types. Human peripheral blood lymphocytes from ...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:10.4149/gpb_2019032
更新日期:2019-09-01 00:00:00
abstract::Pretreatment with diazoxide, mitochondrial K(ATP) channel opener, was found to protect the rat heart against ischemia/reperfusion injury. Our aim was also to characterize the effects of diazoxide on the alterations of regulatory myocardial proteins, on mitochondrial ultrastructure, integrity and induction of apoptotic...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::The hyperpolarisation of the membrane potential in Characeae above that of the diffusion potential is explained by the operation of the electrogenic proton pump. We studied the interaction of calcium with the functioning of the pump. The membrane potential was measured using the standard microelectrode technique. An i...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::Analogs of carbonyl cyanide phenylhydrazone providing no reaction with nucleophilic groups and lacking acidobasic properties, respectively, were synthesized for study of mechanism of uncoupling effect on oxidative phosphorylation. Their retention, influence on proton transport, abilities to SH--groups modify and to st...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::The aim of the present study was to investigate the ability of the chloroacetanilide herbicide acetochlor to interact with the endocrine system. The modulation of the binding of [3H]estradiol-17beta to protamine sulphate-precipitated uterine nuclear and cytoplasmic estrogen receptors was analysed for this purpose. Two...
journal_title:General physiology and biophysics
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00