abstract：:Previously detected βsp and γ1sp dielectric relaxations on the spectrin-based membrane skeleton (MS) of human red blood cells (RBCs) have been shown sensitive to the attachment of MS to the lipid-protein membrane. Such relaxations were now detected on the MS of mammal (rat, horse, bovine, sheep and goat) and "unstrain...

journal_title：General physiology and biophysics

authors： Ivanov IT,Paarvanova BK,Tacheva BB,Slavov T

更新日期：2020-11-01 00:00:00

abstract：:7,8-Dihydroxyflavone (7,8-DHF) is a natural flavonoid compound that act as Trk-B agonist. 7,8-DHF is also a potent antioxidant. When applied systematically, 7,8-DHF can pass through blood-brain barrier and exhibit potential therapeutic effects in several animal models of neurodegenerative disorders. This study investi...

journal_title：General physiology and biophysics

authors： Keser H,Doğramacı Ş,Şahin E,Sağlam N,Erdem M,Alver A,Aydin-Abidin S

更新日期：2020-09-01 00:00:00

abstract：:Nucleosome sliding and nucleosome digestion are two main ways for regulating gene transcription. We constructed three characteristic parameters (CP) based on the information of CG0, CG1 and CG2 motifs, and used these parameters to analyze the sliding trend of -1 and +1 nucleosomes around TSS of genes with NFR in yeast...

journal_title：General physiology and biophysics

authors： Meng H,Li H,Yang Z,Si Y

更新日期：2020-05-01 00:00:00

abstract：:The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to be involved in regulating the levels of inflammatory markers and apoptosis in macrophages. This study aims to investigate the function and regulation of PCSK9 in myocardial ischaemia. The results of our study showed dramatically ...

journal_title：General physiology and biophysics

authors： Yang CL,Zeng YD,Hu ZX,Liang H

更新日期：2020-03-01 00:00:00

abstract：:Gastric cancer (GC) is a high mortality disease. We studied the function and mechanism of long non-coding RNA prostate cancer-associated transcript 6 (lncRNA PCAT6) on cell proliferation and epithelial-mesenchymal transition (EMT) in GC cells. CCK-8, flow cytometry and colony formation assay were respectively used to ...

journal_title：General physiology and biophysics

authors： Dong D,Lun Y,Sun B,Sun H,Wang Q,Yuan G,Quan J

更新日期：2020-01-01 00:00:00

abstract：:Icaritin, a prenylflavonoid derivative from Epimedium Genus, has been reported to exhibit tumor inhibitory effects on many types of tumor cells. Numerous studies have demonstrated that microRNAs (miRs) involve in the biological process of carcinogenesis by controlling expression of their target mRNAs to facilitate tum...

journal_title：General physiology and biophysics

authors： Lu X,Xue B,Zhang T,Zhou X,Zhang Y

更新日期：2019-11-01 00:00:00

abstract：:The substantia gelatinosa of the trigeminal subnucleus caudalis has been considered to be an essential location for the transference of orofacial sensory signals. The co-localization of inhibitory and excitatory neurotransmitters in the same substantia gelatinosa (SG) neurons has demonstrated their essential part in t...

journal_title：General physiology and biophysics

authors： Nguyen HT,Jang SH,Park SJ,Cho DH,Han SK

更新日期：2019-09-01 00:00:00

abstract：:Environmental exposure to modern microwave telecommunication electromagnetic fields (EMFs) has increased to unprecedented levels with consequent health complaints and concerns. Many studies have already reported genotoxic effects on a variety of organisms and cell/tissue types. Human peripheral blood lymphocytes from ...

journal_title：General physiology and biophysics

authors： Panagopoulos DJ

更新日期：2019-09-01 00:00:00

abstract：:The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 ...

journal_title：General physiology and biophysics

authors： Chmelova M,Jezova D,Riecansky I,Hlavacova N

更新日期：2019-07-01 00:00:00

abstract：:Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO2) enhances PGC-1α expression in skeletal muscle. Therefore, the aim of this study was to clarify the effects of...

journal_title：General physiology and biophysics

authors： Matsumoto T,Tanaka M,Nakanish R,Takuwa M,Hirabayashi T,Ono K,Ikeji T,Maeshige N,Sakai Y,Akisue T,Kondo H,Ishihara A,Fujino H

更新日期：2019-05-01 00:00:00

abstract：:Activated endothelial cells play a crucial role in the formation of new blood vessels, a process known as angiogenesis, which can underlie the development of several diseases. Different antiangiogenic therapies aimed against vascular endothelial growth factor (VEGF), the dominant pro-angiogenic cytokine, have been dev...

journal_title：General physiology and biophysics

authors： Horváthová J,Moravčík R,Boháč A,Zeman M

更新日期：2019-03-01 00:00:00

abstract：:Kinase-targeted therapy is a new and promising approach to disease treatment. However, some kinase inhibitors have been observed to cause an off-target adverse risk for skeletal system by influencing the growth of osteoblasts. It is known that the proliferation and differentiation of osteoblasts are essentially regula...

journal_title：General physiology and biophysics

authors： Zhao L,Huang Q,Tian S,Ge J,Zhu H,Dong Q

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of oxidative stress on drug binding affinity, free and bound fraction. The fluorescence anisotropy method was used to examine the interactions of commercial human serum albumin (HSA) and human plasma proteins with ochratoxin A (OTA) or carboxylate form of camptotheci...

journal_title：General physiology and biophysics

authors： Wybranowski T,Ziomkowska B,Cyrankiewicz M,Kruszewski S

更新日期：2018-09-01 00:00:00

abstract：:This study specified the role of several key calcium-operating ion channels in contraction/relaxation of human detrusor muscle as possible target for overactive bladder (OAB) treatment. Detrusor samples, obtained from 18 males (average age 61.5 ± 5.9 years), were investigated by organ tissue bath method with following...

journal_title：General physiology and biophysics

authors： Luptak J,Kocmalova M,Franova S,Sutovsky J,Grendar M,Svihra J,Kliment J Sr,Dusenka R,Sutovska M

更新日期：2018-07-01 00:00:00

abstract：:A number of studies have reported that male reproductive organs are susceptible to electromagnetic fields (EMFs). The aim of this study was to explore the effects of microwave radiation exposures on 6-8 weeks old male Swiss albino mice. Mice were divided into two groups: group I - sham-exposed (Control), and group II ...

journal_title：General physiology and biophysics

authors： Jonwal C,Sisodia R,Saxena VK,Kesari KK

更新日期：2018-07-01 00:00:00

abstract：:Sleep is considered as a physiological regulator in the body. Gamma-aminobutyric acid (GABA) is a neurotransmitter that modulates sleep and affects cardiac functions. We evaluated effects of acute sleep deprivation (SD) on cardiac hemodynamic parameters, expression of pro-inflammatory cytokines, and Heat shock protein...

journal_title：General physiology and biophysics

authors： Parsa H,Faghihi M,Kardar GA,Imani A

更新日期：2018-05-01 00:00:00

abstract：:Malfunction of skeletal muscles and dysregulated turnover of sphingolipids in the insulin responsive tissues have been determined at old age. Present article investigates the role of acid sphingomyelinase (SMase)-dependent ceramide accumulation in reduction of the skeletal muscle sensitivity to insulin action at old a...

journal_title：General physiology and biophysics

authors： Hassouneh LK,Timofiychuk OA,Babenko NA

更新日期：2018-03-01 00:00:00

abstract：:In this study, we investigated the role of AMP-activated protein kinase (AMPK) and the importance of reactive oxygen species (ROS) in apoptosis induction associated with cell cycle arrest induced by sulforaphane in AGS human gastric cancer cells. Our results demonstrated that sulforaphane inhibited proliferation of AG...

journal_title：General physiology and biophysics

authors： Choi YH

更新日期：2018-03-01 00:00:00

abstract：:This study investigated the noradrenergic contribution during the cutaneous vasoconstrictor response to local cooling in the leg and forearm. On each limb, one site was perfused with Yoh/Prop to block the postsynaptic adrenoceptors and another with Lactated Ringer's (control) using microdialysis. Blood flow was measur...

journal_title：General physiology and biophysics

authors： Al-Horani RA,Mohammad M

更新日期：2018-01-01 00:00:00

abstract：:The fibroblast growth factor receptors (FGFRs) and Ras/mitogen activated protein (RAS/MAP) signalling cascades are the main molecular pathways involved in breast carcinogenesis. This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphism...

journal_title：General physiology and biophysics

authors： Dankova Z,Zubor P,Grendar M,Kapinova A,Zelinova K,Jagelkova M,Gondova A,Dokus K,Kalman M,Lasabova Z,Danko J

更新日期：2017-12-01 00:00:00

abstract：:In this study possible connection between radiofrequency exposure (RF) and development of oxidative stress was investigated by measuring impairment in cellular oxidation-reduction balance immediately after RF exposure. Fibroblast cells V79 were exposed for 10, 30 and 60 minutes to 1800 MHz RF radiation. Electric field...

journal_title：General physiology and biophysics

authors： Marjanovic Cermak AM,Pavicic I,Tariba Lovakovic B,Pizent A,Trosic I

更新日期：2017-10-01 00:00:00

abstract：:CRM197, cross-reacting material 197, is a mutant of diphtheria toxin (DTx). CRM197 is used in pharmacology as a carrier protein. It has been recently shown that CRM197 causes breakdown in actin filaments. In order to show intracellular localization of CRM197 and visualize cell structure via actin cytoskeleton, endothe...

journal_title：General physiology and biophysics

authors： Özerman Edis B,Varol B,Hacıosmanoğlu E,Ünlü A,Bektaş M

更新日期：2017-10-01 00:00:00

abstract：:In the present study, we evaluated the antioxidant potential of Artemisia campestris essential oil (ACEO) and the possible protective effects against deltamethrin induced hepatic toxic effects. The ACEO showed radical scavenging activity with IC50 = 47.66 ± 2.51 µg/ml, ferric reducing antioxidant power (FRAP) potentia...

journal_title：General physiology and biophysics

authors： Saoudi M,Ncir M,Ben Ali M,Grati M,Jamoussi K,Allouche N,El Feki A

更新日期：2017-07-01 00:00:00

abstract：:This study examines the effects of a 2.1-GHz WCDMA-modulated microwave (MW) radiation on apoptotic activity and mitochondrial membrane potential (ΔΨm) in MCF-7 cells. The cells were exposed to the MW at a specific absorption rate (SAR) of 0.528 W/kg for 4 or 24 h. The antiproliferative effect of MW exposure was determ...

journal_title：General physiology and biophysics

authors： Esmekaya MA,Canseven AG,Kayhan H,Tuysuz MZ,Sirav B,Seyhan N

更新日期：2017-04-01 00:00:00

abstract：:The ionic composition of intracellular space is rigorously maintained in the expense of high-energy expenditure. It has been recently postulated that the cytoplasmic ionic composition is optimized so the energy cost of the fluctuations of calcium ion concentration is minimized. Specifically, thermodynamic arguments ha...

journal_title：General physiology and biophysics

authors： Głogocka D,Przybyło M,Langner M

更新日期：2017-04-01 00:00:00

abstract：:Diabetic cardiomyopathy is a severe complication of diabetes mellitus (DM). The goal of current work was to study the effects of sinomenine on streptozotocin-induced cardiomyopathy in rats. DM in rats was induced by intraperitoneal injection of streptozotocin. Cardiac function was evaluated by measuring left ventricle...

journal_title：General physiology and biophysics

authors： Jiang C,Tong YL,Zhang D,Liu LZ,Wang JF

更新日期：2017-01-01 00:00:00

abstract：:The human pituitary tumor-transforming gene-1 (hPTTG1) has been found to be overexpressed in various cancers. Accumulated evidences implicate that some of protein kinases can specifically recognize two PXXP motifs at hPTTG1 C-terminus through their Src homology (SH3) domain and then phosphorylate the protein by their ...

journal_title：General physiology and biophysics

authors： Li Y,Li M,Min W,Han G,Wang L,Chen C,Li Z,Zhang Y,Li J,Yue Z

更新日期：2017-01-01 00:00:00

abstract：:Inhibition of angiogenesis involves blocking of tyrosine kinases (TK) implicated in signalling of vascular endothelial growth factor receptors (VEFGR). The inhibition of TK results in a disruption of Ras/Raf/MEK/ERK1/2 and PI3K/Akt signalling pathways. We evaluated recently developed TK inhibitor 22SYM and compared it...

journal_title：General physiology and biophysics

authors： Moravčík R,Stebelová K,Boháč A,Zeman M

更新日期：2016-10-01 00:00:00

abstract：:In P-gp-positive cell variants obtained from L1210 cells either by selection with vincristine (L1210/R) or by transfection with the human gene encoding P-gp (L1210/T), we have previously described cross-resistance to tunicamycin (TNM), a protein N-glycosylation inhibitor. Here we studied whether this cross-resistance ...

journal_title：General physiology and biophysics

authors： Pavlikova L,Seres M,Imrichova D,Hano M,Rusnak A,Zamorova M,Katrlik J,Breier A,Sulova Z

更新日期：2016-10-01 00:00:00

abstract：:Mitochondrial nucleoids (hereafter nucleoids) contain genetic information, mitochondrial DNA, prerequisite for mitochondrial functioning, particularly information required for mitochondrial electron transport. To understand nucleoid functioning, it is imperative to know its ultrastructure and dynamics in the context o...

journal_title：General physiology and biophysics

authors： Prachař J

更新日期：2016-07-01 00:00:00

abstract：:It is well known that in vitro storage lesions lead to membrane dysfunction and decreased number of functional erythrocytes. As erythrocytes get older, in storage media as well as in peripheral circulation, they undergo a variety of biochemical changes. In our study, the erythrocytes with different age groups in citra...

journal_title：General physiology and biophysics

authors： Erman H,Aksu U,Belce A,Atukeren P,Uzun D,Cebe T,Kansu AD,Gelişgen R,Uslu E,Aydın S,Çakatay U

更新日期：2016-07-01 00:00:00

abstract：:Although high-intensity electric fields (HEF) application is currently the only effective therapy available to terminate ventricular fibrillation, it may cause injury to cardiac cells. In this study we determined the relation between HEF pulse length and cardiomyocyte lethal injury. We obtained lethality curves by sur...

journal_title：General physiology and biophysics

authors： Prado LN,Goulart JT,Zoccoler M,Oliveira PX

更新日期：2016-04-01 00:00:00

abstract：:Overconsumption of fructose increases the risk of nonalcoholic fatty liver disease (NAFLD), obesity and metabolic syndrome. NAFLD is currently one of the most common etiologies of chronic liver disease worldwide. The aim of the present study is to evaluate the hepatoprotective potential of zingerone against fructose-e...

journal_title：General physiology and biophysics

authors： Muniandy Narayanan J,Jesudoss VA

更新日期：2016-04-01 00:00:00

abstract：:Beat-to-beat variability of action potential duration (short-term variability, SV) is an intrinsic property of mammalian myocardium. Since the majority of agents and interventions affecting SV may modify also action potential duration (APD), we propose here the concept of relative SV (RSV), where changes in SV are nor...

journal_title：General physiology and biophysics

authors： Magyar J,Kistamás K,Váczi K,Hegyi B,Horváth B,Bányász T,Nánási PP,Szentandrássy N

更新日期：2016-01-01 00:00:00

abstract：:The mechanisms underlying the renoprotective effect for remote limb ischemic preconditioning (rIPC) against renal ischemia/reperfusion injury need further elucidation. In our work, one hundred and twenty male Sprague Dawley rats were randomized into 3 groups; sham, I/R group (left renal 45 min ischemia) and rIPC (as I...

journal_title：General physiology and biophysics

authors： Hussein AM,Harraz AM,Awadalla A,Barakat N,Khater S,Shokeir AA

更新日期：2016-01-01 00:00:00

abstract：:Physical exercise could cause muscle and tissue damage due to increase in the formation of free oxygen radicals during exercise. The aim of the present study was to investigate the effect of crocin on parameters associated with oxidative stress in recovery from acute swimming exercise in rats. Rats were divided into e...

journal_title：General physiology and biophysics

authors： Altinoz E,Ozmen T,Oner Z,Elbe H,Erdemli ME,Bag HG

更新日期：2016-01-01 00:00:00

abstract：:Depression is a brain disorder characterized by severe emotional, cognitive, neuroendocrine and somatic dysfunction. Although the latest generation of antidepressant drugs has improved clinical efficacy and safety, the onset of their clinical effect is significantly delayed after treatment commencement, and a large nu...

journal_title：General physiology and biophysics

authors： Pavlovicova M,Lacinova L,Dremencov E

更新日期：2015-10-01 00:00:00

abstract：:Tissue intermittent hypoxia (IH) occurs in obstructive sleep apnea, sickle cell anemia, physical exercise and other conditions. Poor gas solubility and slow diffusion through culture media hampers mimicking IH-induced transitions of O(2) in vitro. We aimed to develop a system enabling exposure of cultured cells to IH ...

journal_title：General physiology and biophysics

authors： Polak J,Studer-Rabeler K,McHugh H,Hussain MA,Shimoda LA

更新日期：2015-07-01 00:00:00

abstract：:PC12 cells differentiated under the influence of the neuronal growth factor (NGF) serve as a model of both sympathetic neurons and chromaffin cells. NGF-induced differentiation critically depends on elevated intracellular calcium concentration. Main pathway for Ca²⁺ entry in excitable cells is represented by voltage-d...

journal_title：General physiology and biophysics

authors： Lichvárová L,Lacinová Ľ

更新日期：2015-04-01 00:00:00

abstract：:Many herbicides employed in agriculture and also some antibiotics bind to a specific site of the reaction centre protein (RC) blocking the photosynthetic electron transport. Crystal structures showed that all these compounds bind at the secondary ubiquinone (QB) site albeit to slightly different places. Different herb...

journal_title：General physiology and biophysics

authors： Husu I,Magyar M,Szabó T,Fiser B,Gómez-Bengoa E,Nagy L

更新日期：2015-04-01 00:00:00