Abstract：
:A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the net effect of these two changes on an increased tendency for thrombosis needs further evaluation. The PT and APTT continued to remain persistently shortened during the period of use. There was also a general fall in fibrinogen and most other coagulation factors during the two years of use. Thus, again, the net effect of these two changes on the exposed potential for hypercoagulation at the end of the first year needs further evaluation throughout the five years of Norplant-2 use. :A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the net effect of these 2 changes on an increased tendency for thrombosis needs further evaluation. The Prothrombin Time and Actived Partial Thromboplastin Time continued to remain persistently shortened during the period of use. There was also a general fall in fibrinogen and most other coagulation factors during the 2 years of use. Thus, again, the net effect of these 2 changes on the exposed potential for hypercoagulation at the end of the 1st year needs further evaluation throughout the 5 years of Norplant-2 use.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Singh K,Viegas OA,Koh S,Singh P,Ratnam SSdoi
10.1016/s0010-7824(89)80004-6subject
Has Abstractpub_date
1989-02-01 00:00:00pages
155-64issue
2eissn
0010-7824issn
1879-0518pii
S0010-7824(89)80004-6journal_volume
39pub_type
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