A quest for better contraception: the Ford Foundation's contribution to reproductive science and contraceptive development 1959-1983.

Abstract:

:This review describes the Ford Foundation's program of support of research and training in reproductive science and contraceptive development from 1959 through 1983. An appraisal of some of the merits and limitations of that program and of its impact on the field is also presented. :This report offers a comprehensive review of the Ford Foundation's Program in support of reproductive science and contraceptive development from its inception in 1950 to the present time. Discussion covers the genesis of the program and of the administrative and scientific setting it which it arose and details the methods used and the scope of the activities of the program in research and in training and in institutional development. 1 of the most distinctive features of the original concept of the program is the global approach to the problem of fertility control. Over the years several patterns of funding evolved. The essential features of a selected number of grants adhering to each funding pattern are sketched before the more general issues emanating from the specific experiences are described. "core grant" is used to designate those grants made to universities and other research organizations in order to support an institutionwide undertaking in research and training. Because of increasing sources of support in the US, the regional or countrywide programs were mainly situated in less developed countries. These areas presented a greater urgency for improvement in contraceptive technology among their growing populations, and it seemed desirable to facilitate the local development of contraceptive advances. In 1975 a new pattern of grant development and administration was intiated. This plan entailed an announcement of the scientific community of the availability of restricted funds for investigator-initiated projects of limited scope and adaptable to relatively short-term projects. The Mellon Foundation and the Rockefeller Foundation joined with the Ford Foundation in Formulating the Targeted Research Program, 1983-83. The Population Council's Biomedical Division's organization framework and its personnel helped the Ford Foundation staff to sharpen its appraisal of demands made of its resources. In 1970 the Population Council organized the International Committee for Contraception Research [ICCR] to facilitate the pursuit of emerging leads toward better contraceptive modalities, and the Ford Program has provided $9.3 million for ICCR's research program. Considering the program as a whole, the Ford Foundation emerges from the past 25 years of support of research and training in reproductive science and contraceptive development with a creditable record as a donor, initiator, and catalyst.

journal_name

Contraception

journal_title

Contraception

authors

Hertz R

doi

10.1016/0010-7824(84)90024-6

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

107-42

issue

2

eissn

0010-7824

issn

1879-0518

pii

0010-7824(84)90024-6

journal_volume

29

pub_type

杂志文章
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    abstract:BACKGROUND:A new fertility-awareness-based Bridge was developed for postpartum women starting with their first postpartum menses and until they are eligible to use the Standard Days Method®. This article describes the development of the Bridge and theoretical efficacy. STUDY DESIGN:Analysis of a preexisting data set c...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.11.009

    authors: Sinai I,Cachan J

    更新日期:2012-07-01 00:00:00

  • Effect of prophylactic antibiotics on morbidity associated with IUD insertion: results of a pilot randomized controlled trial. IUD Study Group.

    abstract::The efficacy of administering an antibiotic prior to IUD insertion to reduce the risk of introducing an upper genital tract infection during the procedure has not yet been established. Two double-blind randomized studies conducted in Africa comparing a 200 mg prophylactic dose of doxycycline with a placebo did not con...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(94)90019-1

    authors: Walsh TL,Bernstein GS,Grimes DA,Frezieres R,Bernstein L,Coulson AH

    更新日期:1994-10-01 00:00:00

  • Metabolic investigations with Femodene--an oral contraceptive containing gestodene and ethinyloestradiol.

    abstract::The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women. Group 1 consisted of women not currently using oral contraceptives; Group 2 consisted of women switching to Femoden...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(87)90069-2

    authors: Fotherby K,Trayner I,Longthorne PN,Lee B,Watson HR

    更新日期:1987-04-01 00:00:00

  • Bleeding patterns with monophasic and triphasic low-dose ethinyl estradiol combined oral contraceptives.

    abstract:BACKGROUND:This retrospective analysis evaluated the association of age and weight with cycle control in women using either of two formulations of low-estrogen-dose oral contraceptives. STUDY DESIGN:Data for this secondary analysis were derived from a randomized multicenter trial assessing the efficacy and safety of n...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2008.02.007

    authors: Hampton RM,Zhang HF,Barnowski C,Wan GJ

    更新日期:2008-06-01 00:00:00

  • Time-controlled injectable occlusion of the vas deferens.

    abstract::An injectable method of obtaining vas deferens occlusion is presented. The agent used is styrene maleic anhydride (SMA) with dimethyl sulphoxide as the solvent. The special feature of the approach is that after a period of time, spermatozoa passage is spontaneously reestablished. By varying the dose of SMA administere...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(90)90073-5

    authors: Guha SK,Anand S,Ansari S,Farooq A,Sharma DN

    更新日期:1990-03-01 00:00:00

  • Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial.

    abstract:BACKGROUND:This study was conducted to compare breast epithelial-cell proliferation and estrogen and progesterone receptor levels in women taking one of two oral contraceptives (OCs) containing the same dose of estrogen but different doses of the progestin norethindrone (NET). STUDY DESIGN:Thirty-three women were rand...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2011.12.015

    authors: Hovanessian-Larsen L,Taylor D,Hawes D,Spicer DV,Press MF,Wu AH,Pike MC,Pearce CL

    更新日期:2012-09-01 00:00:00

  • Self-administration of misoprostol prior to intrauterine device insertion among nulliparous women: a randomized controlled trial.

    abstract:BACKGROUND:Barriers to intrauterine device (IUD) use in nulliparous women include fear of pain with insertion and provider perception of difficulty with insertion. The goal of this study was to evaluate whether misoprostol prior to IUD insertion in nulliparous women eased insertion and decreased pain. STUDY DESIGN:Thi...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2013.07.011

    authors: Lathrop E,Haddad L,McWhorter CP,Goedken P

    更新日期:2013-12-01 00:00:00

  • Acceptability of Norplant implants for fertility regulation in Singapore.

    abstract::The continuation rate at the end of this five-year clinical study was 60% with no accidental pregnancy occurring throughout the five years. The post-removal conception rate in women desiring pregnancy was 92% at the end of two years. The majority of acceptors described the overall experience with the implants as favou...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(92)90139-k

    authors: Singh K,Viegas OA,Fong YF,Ratnam SS

    更新日期:1992-01-01 00:00:00

  • Comprehensive analysis of the use of pre-procedure ultrasound for first- and second-trimester abortion.

    abstract:BACKGROUND:The use of ultrasound (US) is common in some settings before an abortion procedure. However, its positive effect on the safety or efficacy (ability to complete abortion) of the procedure has not been established. Our aim was to determine whether the use of pre-procedure US improves safety and/or efficacy of ...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2010.06.014

    authors: Kulier R,Kapp N

    更新日期:2011-01-01 00:00:00

  • The effect of depot-medroxyprogesterone acetate on the fetus and nursing infant: a review.

    abstract::Data from published studies of the quantity of medroxyprogesterone acetate and/or its metabolites in the milk of lactating women receiving Depo-Provera for contraception is extrapolated into the amount of drug ingested daily by a theoretically average infant. Comparisons are made with the results of similar studies in...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/0010-7824(81)90027-5

    authors: Schwallie PC

    更新日期:1981-04-01 00:00:00

  • Cervical carcinoma in situ and use of depot-medroxyprogesterone acetate (DMPA). WHO Collaborative Study of Neoplasia and Steroid Contraceptives.

    abstract::The relationship of depot-medroxyprogesterone acetate (D-MPA) use to risk of cervical carcinoma in situ was investigated using data from a large multi-national, hospital-based case-control study. To avoid possible detection bias from Pap smear screening, final analyses were restricted to a subset of cases with symptom...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究

    doi:10.1016/0010-7824(94)00007-j

    authors: Thomas DB,Ye Z,Ray RM

    更新日期:1995-01-01 00:00:00

  • Bioavailability of the Yuzpe and levonorgestrel regimens of emergency contraception: vaginal vs. oral administration.

    abstract::Separate crossover studies compared the bioavailability of oral vs. vaginal routes of administration for the Yuzpe (n=5) and levonorgestrel regimens (n=4) of emergency contraception. Twice the standard dose of the Yuzpe regimen (200 microg of ethinyl estradiol, 1000 microg of levonorgestrel) or the levonorgestrel regi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2004.09.009

    authors: Kives S,Hahn PM,White E,Stanczyk FZ,Reid RL

    更新日期:2005-03-01 00:00:00

  • Studies on mechanism(s) of antifertility action of gossypol in rat and hamster.

    abstract::This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90066-8

    authors: Srivastava A,Gupta G,Setty BS

    更新日期:1989-03-01 00:00:00

  • Levels of contraceptive seroids in breast milk and plasma of lactating women.

    abstract::Levels of contraceptive steroids in breast milk and plasma of lactating women were investigated. 7 lactating women received 150 mg medroxyprogesterone acetate (MPA) 1 week after delivery. 5 women (lactating) took 350 mcg norethisterone (NET) and 2 took 150 mcg d-norgestrel (d-ng) + 30 mcg ethinyl estradiol. Milk an...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(77)90061-0

    authors: Saxena BN,Shrimanker K,Grudzinskas JG

    更新日期:1977-12-01 00:00:00

  • Intraoperative placement of the Copper T-380 intrauterine devices in women undergoing elective cesarean delivery: a pilot study.

    abstract:BACKGROUND:The purpose of this pilot project was to test the feasibility of a technique designed to place a copper intrauterine device (IUD) through the hysterotomy incision of an elective cesarean delivery to minimize possible contamination and to guarantee that tailstrings were visible in the vagina for easy removal ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2009.01.014

    authors: Nelson AL,Chen S,Eden R

    更新日期:2009-07-01 00:00:00

  • Long-term sequelae of tolnidamine on male reproduction and general body metabolism in rabbits.

    abstract::The long-term effects of tolnidamine on male reproduction and general body metabolism were studied in rabbits (Oryctolagus cuniculus). The study was divided into three groups of 10 animals each. The first group (A) received vehicle alone to serve as controls. The second and third groups (B and C) of animals were admin...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(98)00031-6

    authors: Ansari AS,Kumar Y,Srivastava S,Lohiya NK

    更新日期:1998-04-01 00:00:00

  • Safety of mifepristone abortions in clinical use.

    abstract:OBJECTIVES:Extensive data from clinical trials document mifepristone's safety and efficacy for induced abortion, but less information is available about its safety in routine clinical use. METHODS:Data on mifepristone abortion use from the Planned Parenthood Federation of America, the largest provider of mifepristone ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.03.011

    authors: Henderson JT,Hwang AC,Harper CC,Stewart FH

    更新日期:2005-09-01 00:00:00

  • Endometrial safety of a novel monophasic combined oral contraceptive containing 0.02 mg ethinylestradiol and 2 mg chlormadinone acetate administered in a 24/4-day regimen over six cycles.

    abstract:BACKGROUND:This study was conducted to examine whether small doses of ethinylestradiol (EE, 0.02 mg) and chlormadinone acetate (CMA, 2 mg) administered in a novel 24/4-day regimen during six cycles would suffice to suppress proliferation and to cause secretory changes in the endometrium. STUDY DESIGN:This Phase II, ra...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2010.04.013

    authors: Rabe T,Hartschuh E,Wahlstrom T,Höschen K,König S

    更新日期:2010-10-01 00:00:00

  • Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats.

    abstract::Histopathological and biochemical effects of gossypol acetate (GA) on pituitary-gonadal axis were investigated. 10 and 25 mg GA/kg were administered orally to sexually mature adult male Wistar rats for 4 and 5 weeks, respectively. STH and LTH/PRL cells showed no significant changes as compared to those of controls whi...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(92)90162-m

    authors: Udoh P,Patil DR,Deshpande MK

    更新日期:1992-05-01 00:00:00

  • Effect of a once weekly oral contraceptive upon gonadotrophin and gonadal steroid levels.

    abstract::A moderately effective oral progestogen contraceptive, R-2323 (13beta-ethyl-17alpha-ethynyl-17-hydroxy-gona-4,9,11-trien,3-one), was administered weekly in doses of 2.5 mg and 5 mg to 5 subjects each for 8 weeks. In 2 of the 10 treatment cycles of 2.5 mg and 4 of the 10 treatment cycles of 5 mg, progesterone levels i...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(74)90071-7

    authors: Tredway DR,Mishell DR Jr

    更新日期:1974-08-01 00:00:00

  • Recent intrauterine device use and the risk of precancerous cervical lesions and cervical cancer.

    abstract:OBJECTIVE:Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.04.008

    authors: Averbach S,Silverberg MJ,Leyden W,Smith-McCune K,Raine-Bennett T,Sawaya GF

    更新日期:2018-04-17 00:00:00

  • An integrated analysis of vaginal bleeding patterns in clinical trials of Implanon.

    abstract::The vaginal bleeding patterns observed during the use of the single-rod progestin-only implant, Implanon, compared with those seen during the use of the six-capsule implant, Norplant, have been analyzed. The acceptability of these bleeding patterns was also assessed. An integrated analysis of 13 different trials was d...

    journal_title:Contraception

    pub_type: 杂志文章,meta分析,收录出版

    doi:10.1016/s0010-7824(98)00123-1

    authors: Affandi B

    更新日期:1998-12-01 00:00:00

  • Induction of menstruation by antiprogesterone ZK 98.299 in cycling bonnet monkeys.

    abstract::The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(87)90077-1

    authors: Puri CP,Elger WG,Pongubala JM

    更新日期:1987-04-01 00:00:00

  • Inhibition of glycolysis in boar sperm by alpha-chlorohydrin.

    abstract::The effect of alpha-chlorohydrin (3-chloropropan-1,2-diol) on the metabolism of D-[U-14C]-fructose and L-[U-14C]-lactate by washed boar sperm has been investigated. Whereas alpha-chlorohydrin at concentrations as low as 0.1 mM inhibited the metabolism of fructose and led to an increase in the utilization of endogenous...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90103-1

    authors: Hutton P,Dawson AG,Jones AR

    更新日期:1980-11-01 00:00:00

  • Ovarian cysts: presence and persistence with use of a 13.5mg levonorgestrel-releasing intrauterine system.

    abstract:OBJECTIVE:The aim of this study was to assess the presence of ovarian cysts in women using a new low-dose levonorgestrel-releasing intrauterine contraceptive system (LNG-IUS 13.5mg [total content]). STUDY DESIGN:A Phase 3 study assessed LNG-IUS 13.5mg use in healthy women with regular menstrual cycles who requested co...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2015.01.021

    authors: Nahum GG,Kaunitz AM,Rosen K,Schmelter T,Lynen R

    更新日期:2015-05-01 00:00:00

  • Short-term treatment with levonorgestrel does not antagonize the ethinyl estradiol-induced increase of uterine blood flow in postmenopausal women.

    abstract::The aim of this study was to determine the effect of a short-term ethinyl estradiol/levonorgestrel medication on blood flow in the uterine arteries in postmenopausal women in a prospective placebo-controlled double-blind study. Twenty-one healthy postmenopausal woman at least 2 years after menopause received 60 microg...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(97)00122-4

    authors: Entezami M,Heger-Mahn D,Ebert A,Halis G,Lübbert H

    更新日期:1997-09-01 00:00:00

  • The clinical acceptability of a non-medicated vaginal ring.

    abstract::In an open study the acceptability of a newly designed vaginal ring was evaluated. The ring, being developed for contraceptive purposes, was made of Silastic and did not contain any medication. Three groups of 10 healthy female volunteers were selected after informed consent. The 6 nulliparous and 24 parous women were...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(90)90103-3

    authors: Roumen F,Dieben T,Assendorp R,Bouckaert P

    更新日期:1990-08-01 00:00:00

  • Inhibition of LH-induced ovulation in the rat by a hormonal antagonist.

    abstract::A chemically deglycosylated derivative of ovine luteinizing hormone (LH) exhibited appreciable binding to the receptor but had minimal steroidogenic activity. In immature female rats primed with pregnant mare serum gonadotropin, the deglycosylated LH showed low ovulation-inducing activity. Ovulation induced by ovine L...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90037-2

    authors: Sairam MR

    更新日期:1980-06-01 00:00:00

  • Continuous oral low-dosage cyproterone acetate for fertility regulation in the male? A trend analysis in 15 volunteers.

    abstract::The effects of cyproterone acetate (CPA), administered orally in dos es of either 10 or 20 mg/day for 26 weeks, were studied in 15 healthy male volunteers. During treatment, there was a decrease in sperm density and in normal-shaped sperm and an increase in pathological and immature forms, an increase in dead spermat...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(76)90081-0

    authors: Koch UJ,Lorenz F,Danehl K,Ericsson R,Hasan SH,Keyserlingk DV,Lübke K,Mehring M,Römmler A,Schwartz U,Hammerstein J

    更新日期:1976-08-01 00:00:00

  • The influence of hormonal contraceptives on sex hormone binding globulin (SHBG) capacity.

    abstract::The influence of oral contraceptives (OCs) on sex hormone binding globulin (SHBG) capacity was studied in women using OCs for a at least 2 months and compared with values in normal menstruating women, in pregnant women, in postmenopausal women, and in normal males. Binding capacity was measured by ammonium sulfate p...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(75)90050-5

    authors: van Kammen E,Thijssen JH,Rademaker B,Schwarz F

    更新日期:1975-01-01 00:00:00