Abstract：
OBJECTIVE:The objective was to describe the efficacy of medical abortion using mifepristone and misoprostol for gestations less than 6 weeks. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of mifepristone and misoprostol abortion at gestational ages <42 days. Data were independently abstracted by two authors and graded for evidence quality. A pooled analysis of efficacy and a summary odds ratio of abortion failure of <42 days' gestation compared with gestational week 42-49 days were performed for randomized trials as well as for prospective studies. RESULTS:Six randomized controlled trials and nine prospective observational studies met inclusion criteria. Included studies varied greatly in regimens of mifepristone and misoprostol used, and assessment of and timing of outcome of abortion. A pooled proportion of the randomized trials estimated a proportion of unsuccessful abortion of 0.02 (95% confidence interval 0.01-0.03). In the prospective studies, the proportions ranged between 0.02 and 0.17, with considerable heterogeneity in the pooled estimate. However, the two largest observational studies reflected the estimates of the randomized trials (range 0.02-0.03). The summary odds ratios indicated that the odds of unsuccessful abortion were not significantly different between gestational age groups (<42 days versus >42-49 days). DISCUSSION:These analyses support the use of medical abortion at gestational ages <42 days. Efficacy rates are high overall and appear to reflect those observed during the seventh week of pregnancy. Women who prefer to initiate treatment as soon as early pregnancy is diagnosed may do so without delay. IMPLICATIONS:Women can expect success using medical abortion regimens as soon as pregnancy is diagnosed; further research of abortion outcomes disaggregated by gestational age and visualization of the gestational sac is warranted.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Kapp N,Baldwin MK,Rodriguez MIdoi
10.1016/j.contraception.2017.09.006subject
Has Abstractpub_date
2018-02-01 00:00:00pages
90-99issue
2eissn
0010-7824issn
1879-0518pii
S0010-7824(17)30438-9journal_volume
97pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:The aim of this study was to evaluate the effectiveness of lactational amenorrhoea and to determine the relationship between extended breastfeeding and the return of fertility. Breastfeeding pattern, basal body temperature, cervical mucus, salivary ferning, vaginal blood discharge, frequency of sexual intercourse, and...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(00)00101-3
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Concomitant use of antiretroviral (ARV) and hormonal contraceptives may change the metabolism of each and the resulting safety profiles. We evaluated the safety and tolerability of depot medroxyprogesterone acetate (DMPA) among women on ARV. STUDY DESIGN:HIV-infected women on selected ARV regimens or no ARV...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2007.10.002
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Fear of adverse effects on subsequent fertility following reversible contraceptive use is an important concern for some women. STUDY DESIGN:We undertook a comprehensive and objective review of the literature for prospective studies reporting pregnancy rates in women following contraceptive cessation. One-ye...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2011.04.002
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Determining medical abortion outcome commonly includes a costly evaluation such as ultrasonography or serial serum hCG testing. Urine pregnancy testing may represent a less costly alternative. METHODS:This prospective diagnostic test evaluation study was part of a multisite randomized trial of 1080 women un...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2007.01.021
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVES:This study is designed to evaluate the popularity of vasectomy in Iran. The study was conducted to calculate the frequency of vasectomy over time, to compare vasectomy users' characteristics with the general population and whether these characteristics have changed over time. STUDY DESIGN:A cross-sectional ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.07.010
更新日期：2015-11-01 00:00:00
abstract：:A multicentric trial in 9 Spanish Clinics of Family Planning was conducted to evaluate the effectiveness of a vaginal contraceptive Ovule (suppository), containing 18.9 mg of benzalkonium chloride. Gynaecological and cytobacteriological examinations were made to evaluate any possible side-effect. Six-hundred-fifty-thr...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/0010-7824(86)90088-0
更新日期：1986-10-01 00:00:00
abstract：:Introduction of the birth control pill in the United States in 1960 marked the end of a relatively short period of time (< 10 years) to intentionally produce an oral contraceptive, and the beginning of a relatively long period of controversy surrounding the use of the pill. Availability of the pill had an impact on va...
journal_title：Contraception
pub_type： 历史文章,杂志文章
doi：10.1016/s0010-7824(98)00131-0
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. STUDY DESIGN:We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this c...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.08.016
更新日期：2020-12-01 00:00:00
abstract：INTRODUCTION:This prospective observational study evaluated the bleeding patterns of women using a vaginal ring releasing 120 microg of etonogestrel and 15 microg of ethinyl estradiol daily, over a continuous period of 84 days followed by 7 ring-free days. METHODS:The study enrolled 75 volunteers aged 18 to 37 years. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2006.10.009
更新日期：2007-03-01 00:00:00
abstract：:Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg Mi...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(88)90102-3
更新日期：1988-09-01 00:00:00
abstract：PURPOSE:Positive effects on premenstrual symptoms have been observed with low-dose oral contraceptives. Drospirenone is a synthetic progestogen with antiandrogenic and antimineralocorticoid effects. This open-label, multicenter study evaluated the effects of a combination of ethinylestradiol 30 microg and drospirenone ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.contraception.2005.10.016
更新日期：2006-12-01 00:00:00
abstract：:Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were monitored weekly for a period of 12 weeks by measuring 3 pituitary hormones (FSH, LH and prolactin) and 2 ovarian hormones (oestradiol 17-B and progesterone). It was concluded that NET-OEN is a...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(83)80004-3
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Between 7% and 10% of men who choose vasectomy as a contraceptive method regret their decision. This study evaluates the effect of a patient decision aid (PtDA) designed to help men decide whether or not to have a vasectomy. STUDY DESIGN:Men considering vasectomy were randomized to an experimental group tha...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2010.05.003
更新日期：2010-12-01 00:00:00
abstract：:A study was undertaken to determine whether the combination of oral tamoxifen and moistened misoprostol administered vaginally was superior to that of placebo and moistened misoprostol administered vaginally for elective termination of early pregnancies.A clinical trial was conducted with a study group of 150 healthy ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(99)00105-5
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:Maternal trisomy 21 ovarian mosaicism might provide the major causative factor for fetal Down syndrome. The small proportion of trisomy 21 oocytes thought to be retarded in their maturation in comparison to normal disomic ones, and the maternal age effect can be based on an accumulation of trisomy 21 oocytes...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2012.08.040
更新日期：2013-04-01 00:00:00
abstract：:The rheological properties of four commercially available spermicidal gels (two polyacrylic acid derivatives and two carboxymethylcellulose based) and their dilutions with a vaginal fluid simulant (pH 4.2) and a semen simulant (pH 7.7) were measured at 25 degrees C and 37 degrees C over a biologically relevant range o...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00430-4
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:The objective was to determine the effect of routine, opt-out abortion and family planning training on clinical exposure to uterine evacuation, contraception and other gynecologic skills. METHODS:Data from the first 10 years of the Kenneth J. Ryan Residency Training Program in Abortion and Family Planning we...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.02.006
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:There has been some study of women's emotional and psychological well-being after an abortion but no research into women's expectations, at the time of seeking an abortion, of how they will cope after the abortion. STUDY DESIGN:We abstracted counseling needs assessment forms of 5109 women who sought an abor...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2011.11.002
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:This pilot study investigates whether an educational handout could increase short-term information retention about drug interactions between antiepileptic drugs (AEDs) and hormonal contraceptives among female epilepsy patients of reproductive age. STUDY DESIGN:This is a pilot randomized controlled trial of a...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2015.07.008
更新日期：2016-01-01 00:00:00
abstract：:The temporal effects of oral administration of cyproterone acetate (CPA), a progestational androgen receptor blocker, were studied on the fertility of adult male rat sires, at a dose of 20 mg kg-1 day-1 after 15 days of gavage. The treatment reduced the fertility and weights of accessory sex glands, without altering t...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2004.11.003
更新日期：2005-05-01 00:00:00
abstract：:The study reported herein is the primary efficacy and safety study conducted to support U.S. registration of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol. A large multicenter study enrolled 1,221 women at 50 centers in the United Kingdom. A total of 11,656 cycles of e...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0010-7824(92)90094-a
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVE:To understand teen birth trends in Georgia by racial and geographic factors. STUDY DESIGN:We analyzed overall birth and repeat teen birth rates by race, urban/rural status and adequacy of obstetric care from 2008 to 2016 using vital records from all Georgia counties. RESULTS:Overall birth rates among teens ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.11.007
更新日期：2019-03-01 00:00:00
abstract：:The presence of medical conditions that might affect the use of depot-medroxyprogesterone acetate (DMPA) as a contraceptive method was assessed in a rural district in Nepal. A general health survey was conducted in nonpregnant and noncontracepting women aged 15-44 years to determine the presence of any health problems...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(99)00056-6
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:This study was conducted to determine the effects of the monophasic oral contraceptive (OC) containing 30 mcg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) on the nasal respiratory epithelium in premenopausal women. STUDY DESIGN:Fifty premenopausal women participated in the prospective study. Baseline ...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/j.contraception.2007.12.010
更新日期：2008-05-01 00:00:00
abstract：:The effect of 2 long-acting injectables on the plasma protein-bound carbohydrate components and serumucoid when taken for different periods, was illustrated in 100 women of childbearing age. 40 acted as controls, 30 took depot-medroxyprogesterone acetate (DMPA), and 30 took norethisterone enanthate (NET-EN). DMPA wa...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/0010-7824(77)90051-8
更新日期：1977-10-01 00:00:00
abstract：BACKGROUND:Incarcerated women have had limited access to health care prior to their arrest. Although their incarceration presents an opportunity to provide them with health care, their reproductive health needs have been overlooked. STUDY DESIGN:We performed a cross-sectional study of a nationally representative sampl...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.05.126
更新日期：2009-12-01 00:00:00
abstract：:The overall and renal toxicity of racemic gossypol acetic acid was assessed in 6 mongrel dogs. Oral racemic gossypol acetic acid was given orally at doses increasing from 10 to 40 mg/d for a total of 6 weeks in 3 female dogs and from 40 to 80 mg/d for a total of 4 weeks in 3 male dogs. The animals were then sacrificed...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(88)90127-8
更新日期：1988-02-01 00:00:00
abstract：:In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(80)80001-1
更新日期：1980-09-01 00:00:00
abstract：BACKGROUND:Whether contraception affects health-related quality of life (HRQoL) is unclear. STUDY DESIGN:We conducted a cross-sectional analysis of routine intake data collected from women aged 18-50 years, including the RAND-36 (Research and Development Corporation) measure of HRQoL, pregnancy intentions and recent c...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2011.08.004
更新日期：2012-03-01 00:00:00
abstract：:A study was undertaken to determine if copper wire, placed within the uterine lumen after implantation and kept in situ throughout pregnancy, results in an excessive accumulation of the metal in maternal and/or fetal tissues; and if so, what effect if any, such an accumulation may have on both mother and offspring. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90060-2
更新日期：1974-05-01 00:00:00
