Use effectiveness of a spermicidal suppository containing benzalkonium chloride.

Abstract:

:A multicentric trial in 9 Spanish Clinics of Family Planning was conducted to evaluate the effectiveness of a vaginal contraceptive Ovule (suppository), containing 18.9 mg of benzalkonium chloride. Gynaecological and cytobacteriological examinations were made to evaluate any possible side-effect. Six-hundred-fifty-three women at risk of unwanted pregnancy accepted the method as the only contraception during 9,517 months. The results are expressed in life-tables (Tietze-Lewit). Net cumulative first segment rate at 12 months were: terminations 27.2; pregnancy 3.7; medical reason 2.3; planned pregnancy 2.8; other personal reasons 18.4. At 24 months the rates were: terminations 34.1; pregnancy 3.7; medical reason 2.6; planned pregnancy 6.5; personal reasons 21.3. Error or failure to use the spermicide resulted in 12 of 23 pregnancies (52%), while in another 4 pregnancies (17%) there were reasonable elements of doubt concerning its correct use. There were no gynaecological or cytological changes. We conclude that this product is a safe and very effective contraceptive if used according to the prescribed instructions and before any sexual encounter.

journal_name

Contraception

journal_title

Contraception

authors

Méndez F,Castro A,Ortega A

doi

10.1016/0010-7824(86)90088-0

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

353-62

issue

4

eissn

0010-7824

issn

1879-0518

pii

0010-7824(86)90088-0

journal_volume

34

pub_type

临床试验,杂志文章
  • Disparities in contraceptive knowledge, attitude and use between Hispanic and non-Hispanic whites.

    abstract:BACKGROUND:Higher rates of unwanted pregnancies and lower rates of contraceptive use have been reported among Hispanic women than among non-Hispanic whites. Despite these differences, it is unclear how these groups differ with respect to various psychosocial factors that are associated with contraceptive decision makin...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2006.02.010

    authors: Sangi-Haghpeykar H,Ali N,Posner S,Poindexter AN

    更新日期:2006-08-01 00:00:00

  • Midtrimester abortion with intramuscular injection of 15-methyl-prostaglandin F2alpha.

    abstract::This study examines the efficacy and side effects of 15-methyl-prostaglandins F2alpha (PGF2a) free acid administered intramuscularly for midtrimester abortion. 50 healthy women aged 14 to 37 years and between 12 to 18 weeks gestation were randomly selected from the abortion clinic at the Los Angeles County/USC Medica...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(75)90107-9

    authors: Slaughter L,Ballard CA

    更新日期:1975-05-01 00:00:00

  • Effect of a single vaginal administration of levonorgestrel in Carraguard gel on the ovulatory process: a potential candidate for "dual protection" emergency contraception.

    abstract:OBJECTIVE:The study was conducted to evaluate the effect of Carraguard vaginal gel containing 0.75 mg of levonorgestrel (CARRA/LNG gel) administered in a single dose at different stages of follicle development over subsequent follicle rupture and hormonal levels. METHOD:Randomized, blinded, cross-over study comparing ...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2007.04.005

    authors: Brache V,Croxatto H,Sitruk-Ware R,Maguire R,Montero JC,Kumar N,Salvatierra AM,Tejada AS,Cochón L,Forcelledo ML,Lahteenmaki P,Alvarez F,Faundes A

    更新日期:2007-08-01 00:00:00

  • Efficacy and acceptability of testosterone implants, alone or in combination with a 5alpha-reductase inhibitor, for male hormonal contraception.

    abstract::Testosterone (T) treatment suppresses serum gonadotropins and reduces sperm output sufficiently for contraceptive efficacy in approximately 70% of Caucasian men. In the remaining 30% of men, an increase in 5alpha-reductase activity may maintain testicular androgen activity, thus accounting for the failure of sperm sup...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(00)00139-6

    authors: McLachlan RI,McDonald J,Rushford D,Robertson DM,Garrett C,Baker HW

    更新日期:2000-08-01 00:00:00

  • Progestin-only pill use and pill switching during breastfeeding.

    abstract::The opinions of 20 international experts in reproductive endocrinology and family planning service delivery were solicited concerning contraceptive pill use during breastfeeding and, in particular, to determine whether the experts felt that breastfeeding women who use progestin-only pills (POPs) should be advised to s...

    journal_title:Contraception

    pub_type: 社论

    doi:10.1016/0010-7824(95)00076-m

    authors: Visness CM,Rivera R

    更新日期:1995-05-01 00:00:00

  • Long-term use of depot-norethisterone enanthate: effect on blood coagulation factors and menstrual bleeding patterns.

    abstract::Fifty-six women using depot-norethisterone enanthate injections for contraception for 2 years or more were compared with a control group of 48 women not using hormonal contraception. No significant difference was found between the study group and controls for Factors VIIc and Antithrombin III. Factor Xc was reduced in...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(91)90083-r

    authors: McEwan JA,Griffin M

    更新日期:1991-12-01 00:00:00

  • Evaluation of contraceptive activity of a mineralo-herbal preparation in Sprague-Dawley rats.

    abstract:OBJECTIVE:This study was aimed to evaluate a marketed mineralo-herbal preparation containing plants known to have potent contraceptive activity, or contraindicated for use during pregnancy in folklore/ancient Indian literature and recommended for use as an appetizer and headache, hyperacidity and chronic constipation r...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.05.026

    authors: Srivastava SR,Kesarwani S,Keshri G,Singh MM

    更新日期:2005-12-01 00:00:00

  • Apoptosis occurs in implantation site of the rhesus monkey during early stage of pregnancy.

    abstract::The exact role of apoptosis that occurs in human placenta during the early stage of pregnancy remains unknown because of the difficulty in obtaining the intact implantation site. In this study, we used rhesus monkey as an animal model to examine apoptosis occurring in the implantation site at various stages of early p...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00241-4

    authors: Fei G,Peng W,Xin-Lei C,Zhao-Yuan H,Yi-Xun L

    更新日期:2001-09-01 00:00:00

  • The availability of abortion at state hospitals in Turkey: A national study.

    abstract:INTRODUCTION:Abortion in Turkey has been legal since 1983 and remains so today. Despite this, in 2012 the Prime Minister declared that, in his opinion, abortion was murder. Since then, there has been growing evidence that abortion access particularly in state hospitals is being restricted, although no new legislation h...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2016.09.009

    authors: O'Neil ML

    更新日期:2017-02-01 00:00:00

  • Is contraceptive self-injection cost-effective compared to contraceptive injections from facility-based health workers? Evidence from Uganda.

    abstract:OBJECTIVE:To assess the cost-effectiveness of self-injected subcutaneous depot medroxyprogesterone acetate (DMPA-SC) compared to health-worker-administered intramuscular DMPA (DMPA-IM) in Uganda. STUDY DESIGN:We developed a decision-tree model with a 12-month time horizon for a hypothetical cohort of approximately 1 m...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.07.137

    authors: Di Giorgio L,Mvundura M,Tumusiime J,Morozoff C,Cover J,Drake JK

    更新日期:2018-11-01 00:00:00

  • Effects of DL111-IT or combined with RU486 on uterine polyamines biosynthesis in rats during early gestation.

    abstract::DL111-IT, a non-hormonal contragestional agent, revealed synergistic effects in combination with mifepristone (RU486) in some species. The present study was undertaken to clarify the role of DL111-IT when used alone or plus RU486 on uterine polyamines biosynthesis, histologic alteration of decidual cells, and antifert...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00197-4

    authors: Shentu J,Zhou H,He Q,Wang L,Fang R

    更新日期:2001-05-01 00:00:00

  • Fertilizing capacity of human spermatozoa evaluated by actual penetration of foreign eggs.

    abstract::Zona-free hamster oocytes were used to evaluate the entry of human spermatozoa into the oocytes. Suspensions of spermatozoa, free of seminal plasma, were preincubated for varying periods in a modified Tyrode's solution under mineral oil. Zona-free hamster oocytes were prepared and added to the sperm suspension for f...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(78)90064-1

    authors: Barros C,Gonzélez J,Herrera E,Bustos-Obregón E

    更新日期:1978-01-01 00:00:00

  • Women's out-of-pocket expenditures and dispensing patterns for oral contraceptive pills between 1996 and 2006.

    abstract:BACKGROUND:Little is known about the out-of-pocket expenditures and dispensing patterns for oral contraceptive pills (OCPs), factors associated with these outcomes and whether they change over time. STUDY DESIGN:Observational cohort using 1996-2006 Medical Expenditure Panel Surveys. RESULTS:Women spent $16 out-of-poc...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.09.013

    authors: Liang SY,Grossman D,Phillips KA

    更新日期:2011-06-01 00:00:00

  • Safety data for levonorgestrel, ulipristal acetate and Yuzpe regimens for emergency contraception.

    abstract:UNLABELLED:The World Health Organization (WHO) and the US Centers for Disease Control and Prevention (CDC) provide recommendations for use of emergency contraceptive pills (ECPs), including levonorgestrel (LNG) and combined oral contraceptives (COCs). A new ECP formulation, ulipristal acetate (UPA), is now available wo...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2015.11.001

    authors: Jatlaoui TC,Riley H,Curtis KM

    更新日期:2016-02-01 00:00:00

  • Medroxyprogesterone acetate and estradiol cypionate injectable suspension (Cyclofem) monthly contraceptive injection: steady-state pharmacokinetics.

    abstract:BACKGROUND:Cyclofem is a combined injectable contraceptive, containing medroxyprogesterone acetate (MPA) and estradiol cypionate. The objective was to characterize the steady-state pharmacokinetics (PK) using tandem liquid chromatography/mass spectrometry and compare these data to a previous PK study of this formulatio...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2012.11.010

    authors: Thurman A,Kimble T,Hall P,Schwartz JL,Archer DF

    更新日期:2013-06-01 00:00:00

  • Intrauterine devices and endometrial cancer. The WHO Collaborative Study of Neoplasia and Steroid Contraceptives.

    abstract::The relationship between intrauterine device (IUD) use and the development of endometrial cancer was assessed in data from seven countries that were collected between 1979 and 1988 for a multinational hospital-based case-control study. Two hundred twenty-six cases of endometrial cancer were compared with 1,529 control...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(96)00199-0

    authors: Rosenblatt KA,Thomas DB

    更新日期:1996-12-01 00:00:00

  • Seminal fructose in normal and infertile men.

    abstract::Fructose levels and fructolysis index in human semen were analysed to assess a correlation, if any, between the levels of this glycolysable sugar and sperm concentration. Semen was collected from normospermic men and men with azoospermia or oligospermia. Seminal fructose levels were elevated in men with obstructive az...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90062-0

    authors: Rajalakshmi M,Sharma RS,David GF,Kapur MM

    更新日期:1989-03-01 00:00:00

  • How women anticipate coping after an abortion.

    abstract:BACKGROUND:There has been some study of women's emotional and psychological well-being after an abortion but no research into women's expectations, at the time of seeking an abortion, of how they will cope after the abortion. STUDY DESIGN:We abstracted counseling needs assessment forms of 5109 women who sought an abor...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.11.002

    authors: Foster DG,Gould H,Kimport K

    更新日期:2012-07-01 00:00:00

  • Interaction of condom design and user techniques and condom acceptability.

    abstract::In 1991, the source of public sector condom supplies in an African country changed from USAID to WHO. Following a complaint, the two types of condoms were sampled and compared. Laboratory tests indicated that the new-style condoms were of adequate quality, but a number of differences were noted between the two types. ...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/0010-7824(95)00183-b

    authors: Gerofi J,Deniaud F,Friel P

    更新日期:1995-10-01 00:00:00

  • Contraceptive knowledge and use among low-income Hispanic immigrant women and non-Hispanic women.

    abstract:BACKGROUND:With the rising influx of Hispanics to the United States, there is an ongoing need to promote health and wellness care to this non-English-speaking, minority population group. Programs, specifically developed to address the unique cultural mores of Hispanics, need to focus on increasing knowledge about healt...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2007.12.008

    authors: Garcés-Palacio IC,Altarac M,Scarinci IC

    更新日期:2008-04-01 00:00:00

  • Ovulation inhibition by a new low-dose progestagen.

    abstract::A new synthetic progestagen, Org 2969 (13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol) was administered to 9 healthy normally menstruating women. 3 subjects (Group 1) ingested .030 mg, while 6 (Group 2) ingested .015 mg of the compound daily on Days 1-20 of 1 menstrual cycle. The previous menstrual...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(77)90129-9

    authors: Viinikka L,Hirvonen E,Ylikorkala O,Nummi S,Virkkunen P,Ranta T,Alapiessa U,Vihko R

    更新日期:1977-07-01 00:00:00

  • Effects of ethinyl estradiol and ibuprofen compared to placebo on endometrial bleeding, cervical mucus and the postcoital test in levonorgestrel subcutaneous implant users.

    abstract:BACKGROUND:The study was conducted to evaluate ethinyl estradiol (EE) or ibuprofen (IBU) compared to placebo (PL) on spotting and bleeding (S/B) and a postcoital test (PCT) in women using the levonorgestrel subcutaneous implant. Women experiencing excessive S/B were enrolled in a multicenter prospective randomized stud...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2008.04.003

    authors: Archer DF,Philput CB,Levine AS,Cullins V,Stovall TG,Bacon J,Weber ME

    更新日期:2008-08-01 00:00:00

  • "It's a very nuanced discussion with every woman": Health care providers' communication practices during contraceptive counseling for patients with substance use disorders.

    abstract:OBJECTIVE:To explore health care providers' communication practices during contraceptive counseling for women with substance use disorders (SUDs). STUDY DESIGN:In 2019, we conducted semi-structured phone interviews with a purposive sample of medical doctors and advanced practice nurses (n = 24). A two-member team anal...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.09.002

    authors: Charron E,Mayo RM,Heavner-Sullivan SF,Eichelberger KY,Dickes L,Truong KD,Rennert L

    更新日期:2020-11-01 00:00:00

  • Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment.

    abstract::After exposure of young male rats to gossypol acetic acid for various times, a reduction in the content of cellular and microtubular beta-tubulin was found in spermatocytes and spermatids. The content of tubulin was measured by enzyme-linked immunosorbent assay (ELISA). The results were expressed as micrograms tubulin...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(96)00240-5

    authors: Teng CS

    更新日期:1997-01-01 00:00:00

  • A clinical trial of the Delta-T intrauterine device: immediate postpartum insertion.

    abstract::The Copper T-220C intrauterine device was modified for use in early postpartum insertions. Biodegradable extensions consisting of No. 2 chromic suture were added to the horizontal arms of the device to enhance retention. This new device, Delta-T IUD, was inserted in 100 patients within 55 hours of the delivery of the ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(83)90013-6

    authors: Brenner PF

    更新日期:1983-08-01 00:00:00

  • Controversies in family planning: intrauterine device placement in solid organ transplant patients.

    abstract::With an ever-increasing number of reproductive-aged women undergoing solid organ transplant and fertility improving after transplant, knowledge of the safety and efficacy of various contraceptive methods is essential to guide patient selection. We present the case of a 22-year-old patient desiring an intrauterine devi...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2019.05.012

    authors: Gordon C,Harken T

    更新日期:2019-09-01 00:00:00

  • Trends in nonresident abortion rates in New York City from 2005 to 2015: a time series analysis.

    abstract:OBJECTIVES:To examine trends and utilization patterns of NYC abortion services by nonresidents since growing abortion restrictions across many states could drive women to seek care in less restrictive jurisdictions including NYC. STUDY DESIGN:We used data from Induced Termination of Pregnancy certificates filed with t...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.05.008

    authors: Johansson EW,Argov EL,Langston A,Yager A,Searing H,Liu SY

    更新日期:2019-09-01 00:00:00

  • Pituitary and ovarian hormone activity during the 7-day hormone-free interval of various combined oral contraceptive regimens.

    abstract:OBJECTIVE:The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). DESIGN:Blood samples were obtained from 62 women. RESULTS:When COCs were grouped by e...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2014.01.021

    authors: Cho M,Atrio J,Lim AH,Azen C,Stanczyk FZ

    更新日期:2014-07-01 00:00:00

  • Blood hormone levels in egyptian women on norethisterone oenanthate.

    abstract::Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were monitored weekly for a period of 12 weeks by measuring 3 pituitary hormones (FSH, LH and prolactin) and 2 ovarian hormones (oestradiol 17-B and progesterone). It was concluded that NET-OEN is a...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(83)80004-3

    authors: Saleh FM,Sallam HN,Abdel-Rahman H,Souka AR,El-Sahwi SY,Toppozada HK

    更新日期:1983-07-01 00:00:00

  • Induction of menstruation by antiprogesterone ZK 98.299 in cycling bonnet monkeys.

    abstract::The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(87)90077-1

    authors: Puri CP,Elger WG,Pongubala JM

    更新日期:1987-04-01 00:00:00