Abstract：
BACKGROUND:Maternal trisomy 21 ovarian mosaicism might provide the major causative factor for fetal Down syndrome. The small proportion of trisomy 21 oocytes thought to be retarded in their maturation in comparison to normal disomic ones, and the maternal age effect can be based on an accumulation of trisomy 21 oocytes in the ovarian reserve. By lowering the number of unnecessary ovulations, a greater portion of disomic oocytes might be saved. STUDY DESIGN:Between September 2009 and September 2011, we performed genetic amniocentesis for fetal chromosomal analysis in 5222 pregnancies. We detected 119 structural or numerical chromosomal abnormalities. We collected data from 37 cases who were in advanced maternal age and where fetal trisomy 21, 18 or 13 was confirmed. We had 92 control patients. Detailed information was taken from those factors that influence the number of ovulations in reproductive life. RESULTS:From the factors checked, patients with a trisomic fetus had a shorter overall mean length of oral contraceptive pill use before the trisomic pregnancy (3.4 vs. 6.0 years, p<.0014), and the estimated number of mean ovulations was higher (274.6 vs. 224, p<.0003). CONCLUSION:We found that a history of longer oral contraceptive pill use and fewer ovulatory cycles were associated with fewer common trisomies of the fetus. Additional research is needed to rule out potential confounding factors, but our results are consistent with the maternal ovarian mosaicism causal model.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Nagy GR,Győrffy B,Nagy B,Rigó J Jrdoi
10.1016/j.contraception.2012.08.040subject
Has Abstractpub_date
2013-04-01 00:00:00pages
455-8issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(12)00806-2journal_volume
87pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：BACKGROUND:Mirena is a levonorgestrel-releasing intrauterine system (LNG-IUS) that provides highly effective and long-acting progestogen-only contraception. OBJECTIVE:The objective of this study was to analyze the possible effects of using LNG-20 microg IUS on breast-feeding performance, infant growth and infant devel...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2005.04.004
更新日期：2005-11-01 00:00:00
abstract：:Associations between Depo-Provera (injectable, progesterone-only contraceptive) use and visible disruption of cervical epithelium and cervical ectopy were investigated using data collected as part of a cervical cancer screening study in periurban Cape Town, South Africa. Women were interviewed about their contraceptiv...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(99)00049-9
更新日期：1999-06-01 00:00:00
abstract：:After more than a century of reliance on latex condoms, male condoms fabricated from new materials are finally becoming commercially available to consumers. This study was an open label acceptability study that compared three lubricated condom products during vaginal intercourse: a natural rubber latex condom, a polyu...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(00)00119-0
更新日期：2000-06-01 00:00:00
abstract：:As research has shown that knowledge concerning the health risks and benefits of oral contraceptive (OC) use is a contributor to OC compliance, the following study examined an educated sample of young women to determine the level of knowledge concerning the risks and benefits of OC use. A 28-item questionnaire was dev...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(01)00194-9
更新日期：2001-04-01 00:00:00
abstract：:In this longitudinal study involving 100 Singaporean acceptors, the effects of Norplant-2 rods on metabolic function was evaluated. With respect to liver function, the results indicate possible hepatocellular dysfunction. There was a significant rise in mean serum bilirubin from 0.54 mg/dl to 0.85 mg/dl after 12 month...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(88)90086-8
更新日期：1988-10-01 00:00:00
abstract：:Changes in body weight and the incidence of estrogen-related side effects with low-dose oral contraceptives (OCs) containing 20 microg ethinyl estradiol (EE) have not been demonstrated in placebo-controlled trials. Two placebo-controlled, randomized trials demonstrated the efficacy of a low-dose OC for the treatment o...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0010-7824(01)00208-6
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:This study was conducted to evaluate long-term safety of quinacrine pellets for nonsurgical sterilization among women in Vietnam. STUDY DESIGN:Observational cohort study of 2735 women who had quinacrine insertions between 1989 and 1993 compared to 1623 women who received an intrauterine device (IUD). RESUL...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2008.02.011
更新日期：2008-07-01 00:00:00
abstract：:Separate crossover studies compared the bioavailability of oral vs. vaginal routes of administration for the Yuzpe (n=5) and levonorgestrel regimens (n=4) of emergency contraception. Twice the standard dose of the Yuzpe regimen (200 microg of ethinyl estradiol, 1000 microg of levonorgestrel) or the levonorgestrel regi...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/j.contraception.2004.09.009
更新日期：2005-03-01 00:00:00
abstract：:The aim of this prospective study was the follow-up for 2 years in symptoms, serum prolactin (PRL) levels, and radiological aspects of a group of young patients using oral contraceptives (OC) with hyperprolactinemia. A total of 16 hyperprolactinemic women (eight with idiopathic hyperprolactinemia and eight with pituit...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(98)00069-9
更新日期：1998-08-01 00:00:00
abstract：:A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. Restoration of fertility was characterized by a reduction of the litter size resulting from the first inpregnation post-treatment. There was no evidence of tissue pathogenesis 6-12 months after treatment. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90061-x
更新日期：1980-08-01 00:00:00
abstract：BACKGROUND:Within the setting of a UK community sexual health service, the cost-effectiveness of Implanon and oral contraception provision over a 36-month period was compared. STUDY DESIGN:A case-controlled retrospective cost-effectiveness study was done on a cohort of 493 Implanon users and 493 oral contraceptive use...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2008.11.003
更新日期：2009-04-01 00:00:00
abstract：:Blood pyrodoxine hydrochloride (vitamin-B6) concentration was determined in 50 women using combined oral contraceptives (OCs), 24 women who received an intramuscular injection of 150 mg medroxyprogesterone acetate (MPA) every 12 weeks, and in 14 women who used an intrauterine device (IUD) at the out-patient contracep...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90078-x
更新日期：1974-04-01 00:00:00
abstract：BACKGROUND:The study was conducted to characterize the changes in bleeding pattern over time in women receiving the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding (HMB). The reduction in menstrual blood loss volume has been well documented elsewhere. STUDY DESIGN:Post hoc pooled an...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2012.08.022
更新日期：2013-01-01 00:00:00
abstract：:In an open study the acceptability of a newly designed vaginal ring was evaluated. The ring, being developed for contraceptive purposes, was made of Silastic and did not contain any medication. Three groups of 10 healthy female volunteers were selected after informed consent. The 6 nulliparous and 24 parous women were...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(90)90103-3
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. STUDY DESIGN:This study evaluated in v...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.08.014
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:Determine if erythromycin is an effective agent for achieving occlusion of the Fallopian tube for nonsurgical female sterilization. METHODS:Two studies of 100 healthy volunteers requesting sterilization were planned, one in Julpia Andhermanik and the other in Kolkata (Calcutta). A readily available marketed ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2003.07.005
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:This study aims to compare the cost-effectiveness of oral contraceptives (OCs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and surgical management in treating dysfunctional uterine bleeding (DUB) in women not desiring additional children. METHOD:A Markov model was constructed from the perspec...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2006.03.024
更新日期：2006-09-01 00:00:00
abstract：:In a cross-over study with orally administered desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) and 3-keto-desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) in ten women under steady-state conditions, the serum levels of 3-keto-desogestrel were monitored by radioimmunoassay. No statistically significant...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(86)90047-8
更新日期：1986-06-01 00:00:00
abstract：:Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(83)90020-3
更新日期：1983-06-01 00:00:00
abstract：:The results of a prospective longitudinal controlled study comparing the coagulation effects of a standard low-dose combined oral contraceptive (Microgynon 30), a desogestrel-containing pill (Marvelon) and a triphasic preparation (Triquilar) after one year's treatment in ethnic Chinese women is presented in this paper...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(89)90116-9
更新日期：1989-04-01 00:00:00
abstract：:Since peritubular smooth muscle cells (PSMCs) have been characterized, isolated and cultured in homogeneous populations, the regulation of seminiferous epithelium contractility has received increasing attention. The present article reports and discusses experimental evidence demonstrating that: (1) PSMCs express two t...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/s0010-7824(01)00319-5
更新日期：2002-04-01 00:00:00
abstract：:Zona-free hamster oocytes were used to evaluate the entry of human spermatozoa into the oocytes. Suspensions of spermatozoa, free of seminal plasma, were preincubated for varying periods in a modified Tyrode's solution under mineral oil. Zona-free hamster oocytes were prepared and added to the sperm suspension for f...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(78)90064-1
更新日期：1978-01-01 00:00:00
abstract：:We analyzed data from 4,905 women aged 20-39 and 14,803 aged 40-49 who attended a health survey in Norway 1985-88, to study cardiovascular risk factors in users of oral contraceptives, all types and specifically by formulation. In age group 20-39, users of low-dose estrogen/ progestin regimens were younger, had lower ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(96)00082-0
更新日期：1996-06-01 00:00:00
abstract：:For the first time in the 21st century, we have an emerging body of research regarding contraceptive use among adult women with disabilities in the United States. We highlight key findings from population-based analyses that found higher odds of female sterilization and lower odds of long-acting reversible contracepti...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.01.006
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:Ulispristal acetate (UPA) is a selective progesterone receptor modulator widely used for emergency contraception (EC). The described main mechanism of action is by inhibiting or delaying ovulation; however, the postovulatory effects of the drug are still on debate. Therefore, the aim of this study was to dete...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.02.019
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:As part of a strategy to revitalize postpartum family planning services, Government of India revised its policy in 2013 to permit trained nurses and midwives to insert postpartum intrauterine contraceptive devices (PPIUCDs). This study compares two key outcomes of PPIUCD insertions--expulsion and infection--f...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.12.012
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Little is known about attitudes and beliefs among teenagers and young women about the intrauterine device (IUD). STUDY DESIGN:We surveyed 252 women, ages 14-27 years, presenting for appointments at an urban family planning clinic about demographics, sexual and birth control history, and opinions about the I...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2010.02.020
更新日期：2010-08-01 00:00:00
abstract：:This review provides an update of previous estimates of first-year probabilities of contraceptive failure for all methods of contraception available in the United States. Estimates are provided of probabilities of failure during typical use (which includes both incorrect and inconsistent use) and during perfect use (c...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2011.01.021
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:Concern about pain during placement of an intrauterine device (IUD) represents a barrier to use, especially among nulliparous women. We hypothesized that nitroglycerin gel applied vaginally 30 min prior to IUD placement would reduce insertion-related pain. STUDY DESIGN:We designed a randomized, double-blinde...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2014.03.012
更新日期：2014-07-01 00:00:00
abstract：:The aim of this study was to develop a mouse model to investigate the effects of long-term progestin-only exposure on endometrial vascular structure. Normal cycling mice received Silastic implants containing either medroxyprogesterone acetate (MPA) or levonorgestrel (LNG) and were dissected after 1, 3 or 6 weeks. Endo...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2004.04.006
更新日期：2004-10-01 00:00:00
