Abstract：
BACKGROUND:This study was conducted to evaluate long-term safety of quinacrine pellets for nonsurgical sterilization among women in Vietnam. STUDY DESIGN:Observational cohort study of 2735 women who had quinacrine insertions between 1989 and 1993 compared to 1623 women who received an intrauterine device (IUD). RESULTS:Cumulative follow-up times for the quinacrine and IUD cohorts were 28,697 and 17,382 person-years, respectively, and losses to follow-up were 6% and 7%, respectively. Quinacrine users had a higher incidence of ectopic pregnancy compared to IUD users (risk ratio, 2.2; 95% confidence interval, 1.06-4.54); the risks of cancer, hysterectomy, pelvic/gynecologic surgery and death were similar in the two groups. Two quinacrine insertions appeared to lower the risk of ectopic pregnancy to that of surgical tubal occlusion. CONCLUSIONS:Use of quinacrine in this cohort appeared to have minimal health risks. Other research, including preclinical studies, needs to be considered in an overall evaluation of whether the combination of safety and efficacy provide a basis for quinacrine's approval by appropriate regulatory agencies.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Sokal DC,Hieu do T,Loan ND,Hubacher D,Nanda K,Weiner DH,Vach THdoi
10.1016/j.contraception.2008.02.011subject
Has Abstractpub_date
2008-07-01 00:00:00pages
66-72issue
1eissn
0010-7824issn
1879-0518pii
S0010-7824(08)00096-6journal_volume
78pub_type
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