Abstract:
BACKGROUND:New strategies are needed for preventing HIV infection in women. One potential approach is female-initiated use of an effective topical microbicidal gel in combination with a cervical barrier such as the diaphragm. STUDY DESIGN:Randomized, placebo-controlled safety and feasibility trial of diaphragm with vaginal gel during 6 months of use among 120 HIV-negative sexually active women in Johannesburg, South Africa. RESULTS:Pelvic event rates were 338.3 and 247.1 per 100 women-years in the ACIDFORM gel (plus diaphragm) and K-Y(R) Jelly (plus diaphragm) groups, respectively, with a rate ratio of 1.37 (95% CI: 0.89-2.11). Most women found diaphragm with gel use acceptable. CONCLUSION:There was a trend towards more safety events in the ACIDFORM plus diaphragm group, although no primary comparisons achieved statistical significance. Adding an effective microbicidal gel to a mechanical barrier may still prove to be an important and acceptable combination method to help prevent pregnancy and HIV/sexually transmitted infection transmission.
journal_name
Contraceptionjournal_title
Contraceptionauthors
von Mollendorf CE,Van Damme L,Moyes JA,Rees VH,Callahan MM,Mauck CK,Puren AJ,Tweedy K,Taylor Ddoi
10.1016/j.contraception.2009.10.011subject
Has Abstractpub_date
2010-03-01 00:00:00pages
232-9issue
3eissn
0010-7824issn
1879-0518pii
S0010-7824(09)00457-0journal_volume
81pub_type
杂志文章,随机对照试验相关文献
CONTRACEPTION文献大全abstract::Mifepristone-induced abortion is increasingly common. Recent alerts have highlighted the occurrence of infrequent but serious complications. We report a case of serious bacterial infection after medical termination that occurred in the absence of the usual signs of infection. ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.09.003
更新日期:2006-04-01 00:00:00
abstract::A moderately effective oral progestogen contraceptive, R-2323 (13beta-ethyl-17alpha-ethynyl-17-hydroxy-gona-4,9,11-trien,3-one), was administered weekly in doses of 2.5 mg and 5 mg to 5 subjects each for 8 weeks. In 2 of the 10 treatment cycles of 2.5 mg and 4 of the 10 treatment cycles of 5 mg, progesterone levels i...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(74)90071-7
更新日期:1974-08-01 00:00:00
abstract:BACKGROUND:There is a lack of information concerning the decision factors and sources of information influencing women who purposefully deviate from the prescribed use of their combined hormone contraceptives to exert elective control of their scheduled bleeding. STUDY DESIGN:A self-administered email survey of schedu...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.12.012
更新日期:2013-09-01 00:00:00
abstract::This study analyzed data gathered from a survey of online information on the intrauterine device (IUD) to determine the content and quality of information available to consumers and providers, as evidenced by the presence or absence of a series of attributes measuring the accuracy and objectiveness of information prov...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2003.07.001
更新日期:2003-11-01 00:00:00
abstract::A polyethylene intrauterine device (IUD) inserted in one horn of the rat uterus on Day 2 of pregnancy prevented implantation in 9 out of 12 rats in the horn with the device. When polyphloretin phosphate (PPP), a substance known to inhibit alkaline phosphatase, was administered to such rats from Day 1 till Day 5 of pre...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90016-1
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. STUDY DESIGN:We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this c...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.08.016
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To describe real-world care seeking and contraception provision in one direct to consumer telemedicine platform. STUDY DESIGN:We described encounters with reproductive age female patients between July 2016 and July 2018 seeking contraception on the American Well telemedicine platform. RESULTS:Of 126,712 tot...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.01.017
更新日期:2020-05-01 00:00:00
abstract::The purpose of the study was to evaluate semen quality in young Chinese men and to establish reference values. Normal healthy young men from seven geographical areas were enrolled. The study showed that the mean sperm volume was 2.61 mL, and mean percent of sperm with forward progression was 59.89, while median of sem...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00281-0
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:An informed, timely referral from a generalist practitioner has the potential to facilitate care for a patient seeking an abortion. However it is unclear what barriers, if any, generalist practitioners perceive in this process. The objective of this study was to qualitatively characterize abortion referral pa...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.10.009
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:All Tanzanian abortion estimates rely on health facility data that do not take into account completely the incidence of abortion. This papers aims to estimate the lifetime incidence of induced abortion in Arusha, Tanzania via direct and double list-experiment methods using community data and evaluate outcome...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.10.013
更新日期:2021-02-01 00:00:00
abstract::In Lebanon, coitus interruptus or withdrawal remains a widely practiced method of family planning. Our research sought to understand the role of men in reproductive health in Lebanon by focusing on this common practice. Our main questions were: Why is it that the practice persists when more effective modern methods of...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00304-3
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:In response to concerns about serious infections following medical abortion, in early 2006 the Planned Parenthood Federation of America changed the route of misoprostol administration from vaginal to buccal and required either routine antibiotic coverage or universal screening and treatment for chlamydia; in...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.08.022
更新日期:2011-04-01 00:00:00
abstract::High speed cinematography of latex condoms inflated to burst under standard (ISO) conditions reveals that rupture of the condom typically is initiated at a small focal point on the shank of the condom and then rapidly propagates throughout the condom's surface, often ending with partial or full severance of the condom...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(09)91004-6
更新日期:1990-06-01 00:00:00
abstract::Researchers, health care providers, women's health advocates, donors, and representatives of ministries of health convened in Bellagio, Italy, in July 1998, to assess the potential of medical methods of early pregnancy termination to improve the reproductive health of women in developing countries. Consensus was reac...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(98)00109-7
更新日期:1998-11-01 00:00:00
abstract::DL111-IT, a non-hormonal contragestional agent, revealed synergistic effects in combination with mifepristone (RU486) in some species. The present study was undertaken to clarify the role of DL111-IT when used alone or plus RU486 on uterine polyamines biosynthesis, histologic alteration of decidual cells, and antifert...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00197-4
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Incarcerated women have had limited access to health care prior to their arrest. Although their incarceration presents an opportunity to provide them with health care, their reproductive health needs have been overlooked. STUDY DESIGN:We performed a cross-sectional study of a nationally representative sampl...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2009.05.126
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effectiveness of a refined theory-based Interactive Postpartum Sexual Health Education Program to enhance postpartum women's effective contraceptive behavior. STUDY DESIGN:Participants (N=250) were randomized to three groups. Experimental Group A received our interv...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2010.11.008
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.04.008
更新日期:2018-04-17 00:00:00
abstract::The vaginal bleeding patterns observed during the use of the single-rod progestin-only implant, Implanon, compared with those seen during the use of the six-capsule implant, Norplant, have been analyzed. The acceptability of these bleeding patterns was also assessed. An integrated analysis of 13 different trials was d...
journal_title:Contraception
pub_type: 杂志文章,meta分析,收录出版
doi:10.1016/s0010-7824(98)00123-1
更新日期:1998-12-01 00:00:00
abstract::This review provides an update of previous estimates of first-year probabilities of contraceptive failure for all methods of contraception available in the United States. Estimates are provided of probabilities of failure during typical use (which includes both incorrect and inconsistent use) and during perfect use (c...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2011.01.021
更新日期:2011-05-01 00:00:00
abstract::A simple survey was made of health-care providers to determine their attitudes toward oral contraceptives containing more than 50 mcg of estrogen. It was found that about two-thirds of respondents prescribe this group of medication, although few do so regularly. Their use seemed correlated with providers 40 years of a...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(88)90159-x
更新日期:1988-11-01 00:00:00
abstract::The aim of this guidance is to review the management of unacceptable vaginal bleeding patterns in etonogestrel (ENG)-releasing contraceptive implant users concentrating, where possible, on the evidence for pharmacological treatments and identifying a pragmatic approach where this is not possible. This article was deve...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2010.08.001
更新日期:2011-03-01 00:00:00
abstract::One-hundred-thirty of 178 women who received Norplant-2 implants were followed prospectively for 4 years. Menstrual disorders were the most common reason for discontinuation. Only one patient conceived, for a failure rate of 0.6%. ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00265-7
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:While the intra-uterine device (IUD) is the second most popular contraceptive method in France, its use remains low among women most at risk of unintended pregnancies. Acknowledging the conjoint role of women and physicians in contraceptive decision making, we investigate the determinants of IUD use and IUD r...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.10.003
更新日期:2014-01-01 00:00:00
abstract::The effect of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro-5-triazole (5,1a)-isoquinoline, a non-hormonal post-implantational anti-fertility drug, on tissue weights, nucleic acids and total protein concentrations in the testes, ventral prostate and seminal vesicles were evaluated in immature and sexually mature rats, while ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(87)90008-4
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVES:Extensive data from clinical trials document mifepristone's safety and efficacy for induced abortion, but less information is available about its safety in routine clinical use. METHODS:Data on mifepristone abortion use from the Planned Parenthood Federation of America, the largest provider of mifepristone ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.03.011
更新日期:2005-09-01 00:00:00
abstract::The ability of 40 mg of milled suspension of a new long-acting androgen ester (20 Aet-1) to restore and maintain accessory gland function was compared with that of testosterone enanthate (TE) in castrated adult rhesus monkeys. Castration did not abolish the ejaculatory response since only two animals did not void seme...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(91)90129-4
更新日期:1991-01-01 00:00:00
abstract::A comparative study of the performance of multi-sizes of the Mahua Ring inserted following measurement of the uterine cavity and one size of the same ring assigned at random was carried out from November 1984 to September 1985 at two hospitals in Tianjin. The experiences of 800 acceptors were analysed by life-table te...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(90)90048-z
更新日期:1990-10-01 00:00:00
abstract::The mechanism of copper in limiting intrauterine infections in intrauterine device (Cu IUD) users is poorly understood. Copper ions may enhance the release of reactive oxygen radicals, which in turn decrease the release of reactive nitrogen intermediates (RNI). RNI are known to have bactericidal effect. The present st...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(97)00037-1
更新日期:1997-05-01 00:00:00
abstract::Hepatic function in female rats given 200 microgram of quinestrol every 15 days for up to 210 days was studied. Prolonged treatment with quinestrol affected liver weight, serum cholestrol levels, biliar flux, and bromosulphthalein test, but these parameters tended toward control levels after 30 days of treatment. Quin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(78)80021-3
更新日期:1978-09-01 00:00:00